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Internal Medicine

Recent Publications

Galectin-3C Inhibits Tumor Growth and Increases the Anticancer Activity of Bortezomib in a Murine Model of Human Multiple Myeloma. Mirandola L, Yu Y, Chui K, Jenkins MR, Cobos E, John CM, Chiriva-Internati M. PLoS One. 2011;6(7):e21811. Epub 2011 Jul 13. PMID: 21765917 [PubMed - in process] Free PMC Article Free full text Related citations

Cancer testis antigen, ropporin, is a potential target for multiple myeloma immunotherapy. Chiriva-Internati M, Mirandola L, Yu Y, Jenkins MR, Gornati R, Bernardini G, Gioia M, Chiaramonte R, Cannon MJ, Kast WM, Cobos E. J Immunother. 2011 Jul-Aug;34(6):490-9. PMID: 21654522 [PubMed - in process] Related citations

Notch-ing from T-cell to B-cell lymphoid malignancies. Mirandola L, Comi P, Cobos E, Kast WM, Chiriva-Internati M, Chiaramonte R. Cancer Lett. 2011 Sep 1;308(1):1-13. PMID: 21652011 [PubMed - in process] Related citations

Genistein inhibited proliferation and induced apoptosis in acute lymphoblastic leukemia, lymphoma and multiple myeloma cells in vitro. Li W, Frame LT, Hoo KA, Li Y, D'Cunha N, Cobos E. Leuk Lymphoma. 2011 Jul 13. [Epub ahead of print] PMID: 21749310 [PubMed - as supplied by publisher] Related citations

CRM1-dependent p53 nuclear accumulation in lung lesions of a bitransgenic mouse lung tumor model. Chen L, Moore JE, Samathanam C, Shao C, Cobos E, Miller MS, Gao W. Oncol Rep. 2011 Jul;26(1):223-8. doi: 10.3892/or.2011.1279. Epub 2011 Apr 21. PMID: 21519798 [PubMed - in process] Related citations

Sperm protein 17: clinical relevance of a cancer/testis antigen, from contraception to cancer immunotherapy, and beyond. Chiriva-Internati M. Int Rev Immunol. 2011 Apr-Jun;30(2-3):138-49. PMID: 21557640 [PubMed - in process] Related citations

Cancer testis antigens: novel biomarkers and targetable proteins for ovarian cancer. Mirandola L, J Cannon M, Cobos E, Bernardini G, Jenkins MR, Kast WM, Chiriva-Internati M. Int Rev Immunol. 2011 Apr-Jun;30(2-3):127-37. PMID: 21557639 [PubMed - in process] Related citations

Prospects and challenges for immunotherapy of ovarian cancer--what can we learn from the tumor microenvironment? Chiriva-Internati M, Cobos E, Cannon MJ. Int Rev Immunol. 2011 Apr-Jun;30(2-3):67-70. PMID: 21557634 [PubMed - in process] Related citations

Understanding the cross-talk between ovarian tumors and immune cells: mechanisms for effective immunotherapies. Chiriva-Internati M, Mirandola L, Kast WM, Jenkins MR, Cobos E, Cannon MJ. Int Rev Immunol. 2011 Apr-Jun;30(2-3):71-86. PMID: 21557635 [PubMed - in process] Related citations

Identification of AKAP-4 as a new cancer/testis antigen for detection and immunotherapy of prostate cancer. Chiriva-Internati M, Yu Y, Mirandola L, D'Cunha N, Hardwicke F, Cannon MJ, Cobos E, Kast WM. Prostate. 2011 Apr 25. doi: 10.1002/pros.21400. [Epub ahead of print] PMID: 21520158 [PubMed - as supplied by publisher] Related citations

Dendritic cell vaccination against ovarian cancer--tipping the Treg/TH17 balance to therapeutic advantage? Cannon MJ, Goyne H, Stone PJ, Chiriva-Internati M. Expert Opin Biol Ther. 2011 Apr;11(4):441-5. Epub 2011 Jan 28. Review. PMID: 21271951 [PubMed - indexed for MEDLINE] Related citations

Nanotechnology and human health: risks and benefits. Cattaneo AG, Gornati R, Sabbioni E, Chiriva-Internati M, Cobos E, Jenkins MR, Bernardini G. J Appl Toxicol. 2010 Nov;30(8):730-44. doi: 10.1002/jat.1609. Review. PMID: 21117037 [PubMed - indexed for MEDLINE] Related citations

Ukrain affects pancreas cancer cell phenotype in vitro by targeting MMP-9 and intra-/extracellular SPARC expression. Funel N, Costa F, Pettinari L, Taddeo A, Sala A, Chiriva-Internati M, Cobos E, Colombo G, Milzani A, Campani D, Dalle-Donne I, Gagliano N. Pancreatology. 2010;10(5):545-52. Epub 2010 Oct 23. PMID: 20975318 [PubMed - indexed for MEDLINE] Related citations

Cancer testis antigen vaccination affords long-term protection in a murine model of ovarian cancer. Chiriva-Internati M, Yu Y, Mirandola L, Jenkins MR, Chapman C, Cannon M, Cobos E, Kast WM. PLoS One. 2010 May 12;5(5):e10471. PMID: 20485677 [PubMed - indexed for MEDLINE] Free PMC Article Free full text Related citations

An update on hematological malignancies. D'Cunha N, Cobos E. Tex Med. 2010 Sep 1;106(9):59-63. PMID: 20809446 [PubMed - in process] Related citations

Glioma-astrocyte interaction modifies the astrocyte phenotype in a co-culture experimental model. Gagliano N, Costa F, Cossetti C, Pettinari L, Bassi R, Chiriva-Internati M, Cobos E, Gioia M, Pluchino S. Oncol Rep. 2009 Dec;22(6):1349-56. PMID: 19885586 [PubMed - indexed for MEDLINE] Related citations

Sperm protein 17 is expressed in the sperm fibrous sheath. Chiriva-Internati M, Gagliano N, Donetti E, Costa F, Grizzi F, Franceschini B, Albani E, Levi-Setti PE, Gioia M, Jenkins M, Cobos E, Kast WM. J Transl Med. 2009 Jul 15;7:61. PMID: 19604394 [PubMed - indexed for MEDLINE] Free PMC Article Free full text Related citations

Expression profiling of genes involved in collagen turnover in tendons from cerebral palsy patients. Gagliano N, Pelillo F, Chiriva-Internati M, Picciolini O, Costa F, Schutt RC Jr, Gioia M, Portinaro N. Connect Tissue Res. 2009;50(3):203-8. PMID: 19444761 [PubMed - indexed for MEDLINE] Related citations

rAAV/Her-2/neu loading of dendritic cells for a potent cellular-mediated MHC class I restricted immune response against ovarian cancer. Yu Y, Pilgrim P, Zhou W, Gagliano N, Frezza EE, Jenkins M, Weidanz JA, Lustgarten J, Cannon M, Bumm K, Cobos E, Kast WM, Chiriva-Internati M. Viral Immunol. 2008 Dec;21(4):435-42. PMID: 19115932 [PubMed - indexed for MEDLINE] Related citations

A new immunomodulatory therapy for severe sepsis: Ulinastatin Plus Thymosin {alpha} 1. Li Yumin, Chen Hao, Li Xun, Zhou Wence, He Minyan, Chiriva-Internati M, Wachtel MS, Frezza EE. J Intensive Care Med. 2009 Jan-Feb;24(1):47-53. Epub 2008 Nov 25. PMID: 19033321 [PubMed - indexed for MEDLINE] Related citations

Transduction of PACAP38 protects primary cortical neurons from neurotoxic injury. Sanchez A, Chiriva-Internati M, Grammas P. Neurosci Lett. 2008 Dec 19;448(1):52-5. Epub 2008 Oct 14. PMID: 18938212 [PubMed - indexed for MEDLINE] Free PMC Article Free full text Related citations

Protective CD8+ T-cell responses to cytomegalovirus driven by rAAV/GFP/IE1 loading of dendritic cells. Yu Y, Pilgrim P, Yan J, Zhou W, Jenkins M, Gagliano N, Bumm K, Cannon M, Milzani A, Dalle-Donne I, Kast WM, Cobos E, Chiriva-Internati M. J Transl Med. 2008 Oct 5;6:56. PMID: 18834548 [PubMed - indexed for MEDLINE] Free PMC Article Free full text Related citations

Biological treatment for liver tumor and new potential biomarkers. Chiriva-Internati M, Grizzi F, Wachtel MS, Jenkins M, Ferrari R, Cobos E, Frezza EE. Dig Dis Sci. 2008 Mar;53(3):836-43. Epub 2007 Aug 22. Review. PMID: 17712633 [PubMed - indexed for MEDLINE] Related citations

Effect of a topical treatment in organotypic culture of human breast skin after exposure to gamma-rays. Gagliano N, Bedoni M, Mantovani G, Chiriva-Internati M, Castelli D, Torri C, Donetti E. Eur J Histochem. 2007 Oct-Dec;51(4):283-90. PMID: 18162458 [PubMed - indexed for MEDLINE] Related citations

AKAP-4: a novel cancer testis antigen for multiple myeloma. Chiriva-Internati M, Ferrari R, Yu Y, Hamrick C, Gagliano N, Grizzi F, Frezza E, Jenkins MR, Hardwicke F, D'Cunha N, Kast WM, Cobos E. Br J Haematol. 2008 Feb;140(4):465-8. No abstract available. PMID: 18217892 [PubMed - indexed for MEDLINE] Related citations

A paradigm shift in therapeutic vaccination of cancer patients: the need to apply therapeutic vaccination strategies in the preventive setting. Gray A, Raff AB, Chiriva-Internati M, Chen SY, Kast WM. Immunol Rev. 2008 Apr;222:316-27. Review. PMID: 18364011 [PubMed - indexed for MEDLINE] Related citations

The pituitary tumor transforming gene 1 (PTTG-1): an immunological target for multiple myeloma. Chiriva-Internati M, Ferrari R, Prabhakar M, Yu Y, Baggoni L, Moreno J, Gagliano N, Portinaro N, Jenkins MR, Frezza EE, Hardwicke F, D'Cunha N, Kast W, Cobos E. J Transl Med. 2008 Apr 2;6:15. PMID: 18384692 [PubMed - indexed for MEDLINE] Free PMC Article Free full text Related citations

Silibinin restores paclitaxel sensitivity to paclitaxel-resistant human ovarian carcinoma cells. Zhou L, Liu P, Chen B, Wang Y, Wang X, Chiriva Internati M, Wachtel MS, Frezza EE. Anticancer Res. 2008 Mar-Apr;28(2A):1119-27. PMID: 18507063 [PubMed - indexed for MEDLINE] Related citations

Sperm fibrous sheath proteins: a potential new class of target antigens for use in human therapeutic cancer vaccines. Chiriva-Internati M, Cobos E, Da Silva DM, Kast WM. Cancer Immun. 2008 Apr 24;8:8. Review. PMID: 18433090 [PubMed - indexed for MEDLINE] Free PMC Article Free full text Related citations

Analysis of the results of sleeve gastrectomy for morbid obesity and the role of ghrelin. Frezza EE, Chiriva-Internati M, Wachtel MS. Surg Today. 2008;38(6):481-3. Epub 2008 May 31. Review. PMID: 18516524 [PubMed - indexed for MEDLINE] Related citations

A therapeutic dose of FK506 does not affect collagen turnover pathways in healthy human gingival fibroblasts. Gagliano N, Moscheni C, Tartaglia GM, Selleri S, Chiriva-Internati M, Cobos E, Torri C, Costa F, Pettinari L, Gioia M. Transplant Proc. 2008 Jun;40(5):1419-24. PMID: 18589121 [PubMed - indexed for MEDLINE] Related citations

Sperm protein 17 is a suitable target for adoptive T-cell-based immunotherapy in human ovarian cancer. Chiriva-Internati M, Weidanz JA, Yu Y, Frezza EE, Jenkins MR, Kennedy RC, Cobos E, Kast WM. J Immunother. 2008 Oct;31(8):693-703. PMID: 18779750 [PubMed - indexed for MEDLINE] Related citations

Usefulness of cancer-testis antigens as biomarkers for the diagnosis and treatment of hepatocellular carcinoma. Grizzi F, Franceschini B, Hamrick C, Frezza EE, Cobos E, Chiriva-Internati M. J Transl Med. 2007 Jan 23;5:3. Review. PMID: 17244360 [PubMed - indexed for MEDLINE] Free PMC Article Free full text Related citations

The multiple faces of glucagon-like peptide-1--obesity, appetite, and stress: what is next? A review. Frezza EE, Wachtel MS, Chiriva-Internati M. Dig Dis Sci. 2007 Mar;52(3):643-9. Review. PMID: 17268838 [PubMed - indexed for MEDLINE] Related citations

Human binucleate hepatocytes: are they a defence during chronic liver diseases? Grizzi F, Chiriva-Internati M. Med Hypotheses. 2007;69(2):258-61. Epub 2007 Feb 20. PMID: 17307305 [PubMed - indexed for MEDLINE] Related citations

A NOD/SCID tumor model for human ovarian cancer that allows tracking of tumor progression through the biomarker Sp17. Chiriva-Internati M, Grizzi F, Weidanz JA, Ferrari R, Yuefei Y, Velez B, Shearer MH, Lowe DB, Frezza EE, Cobos E, Kast WM, Kennedy RC. J Immunol Methods. 2007 Apr 10;321(1-2):86-93. Epub 2007 Feb 9. PMID: 17336323 [PubMed - indexed for MEDLINE] Related citations

Increased age, male gender, and cirrhosis, but not steatosis or a positive viral serology, negatively impact the life expectancy of patients who undergo liver biopsy. Wachtel MS, Zhang Y, Kaye KE, Chiriva-Internati M, Frezza EE. Dig Dis Sci. 2007 Sep;52(9):2276-81. Epub 2007 Apr 4. PMID: 17406827 [PubMed - indexed for MEDLINE] Related citations

Calcitonin receptor-stimulated migration of prostate cancer cells is mediated by    urokinase receptor-integrin signaling. Thomas S, Chiriva-Internati M, Shah GV. Clin Exp Metastasis. 2007;24(5):363-77. Epub 2007 May 9. PMID: 17487556 [PubMed - indexed for MEDLINE] Related citations

Geometry of human vascular system: is it an obstacle for quantifying antiangiogenic therapies?Grizzi F, Colombo P, Taverna G, Chiriva-Internati M, Cobos E, Graziotti P, Muzzio PC, Dioguardi N. Appl Immunohistochem Mol Morphol. 2007 Jun;15(2):134-9. Review. PMID: 17525623 [PubMed - indexed for MEDLINE] Related citations

Advances in immunotherapy of multiple myeloma: from the discovery of tumor-associated antigens to clinical trials. Chiriva-Internati M, Cobos E, Kast WM. Int Rev Immunol. 2007 May-Aug;26(3-4):197-222. Review. PMID: 17558744 [PubMed - indexed for MEDLINE] Related citations

The role of radiofrequency ablation in multiple liver metastases to debulk the tumor: a pilot study before alternative therapies. Frezza EE, Wachtel MS, Barragan B, Chiriva-Internati M, Cobos E. J Laparoendosc Adv Surg Tech A. 2007 Jun;17(3):282-4. PMID: 17570770 [PubMed - indexed for MEDLINE] Related citations

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