Pharmacology and Neuroscience
Dr. Thomas E. Tenner, Jr. - Joint Appointment
Professor of Pharmacology
Ph.D., 1976, University of Texas Health Science Center, San Antonio
Effects of Chronic Drug Therapies/Disease States on Cardiovascular Signal Transduction.
Research activity is concerned with studying modulatory effects of chronic drug administration
and/or disease states on cardiovascular function. The major thrust of this research
involves the study of cardiovascular complications associated with diabetes mellitus
in animal models. Recent studies have evaluated the role of oxidative stress in diabetic-induced
cardiovascular complications. Currently, our focus is on an original observation made
in this lab, that a group of anti-diabetic drugs known as Peroxisome Proliferator-Activated
Receptor Gamma (PPAR y) ligands induce lipid sequestration in cultured rabbit aortic vascular smooth muscle
cells (VSMC). These drugs are known to possess anti-proliferative effect in VSMC,
thought to be an anti-atherogenic effect, and therefore protective. However, the impact
of drug-induced lipid sequestration in VSMC on atherogenesis remains unknown. Other
areas of interest include the potential anti-diabetic effects of taurine and the role
of beta-adrenoceptor regulation in diabetic induced cardiomyopathy.
For a complete list of publications by Thomas E. Tenner in PubMed, click here
Dr. Thomas E. Tenner, Jr.