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Pharmacology and Neuroscience

Dr. Thomas E. Tenner, Jr. - Joint Appointment

Professor of Pharmacology
Ph.D., 1976, University of Texas Health Science Center, San Antonio

Effects of Chronic Drug Therapies/Disease States on Cardiovascular Signal Transduction.

Research activity is concerned with studying modulatory effects of chronic drug administration and/or disease states on cardiovascular function. The major thrust of this research involves the study of cardiovascular complications associated with diabetes mellitus in animal models. Recent studies have evaluated the role of oxidative stress in diabetic-induced cardiovascular complications. Currently, our focus is on an original observation made in this lab, that a group of anti-diabetic drugs known as Peroxisome Proliferator-Activated Receptor Gamma (PPAR y) ligands induce lipid sequestration in cultured rabbit aortic vascular smooth muscle cells (VSMC). These drugs are known to possess anti-proliferative effect in VSMC, thought to be an anti-atherogenic effect, and therefore protective. However, the impact of drug-induced lipid sequestration in VSMC on atherogenesis remains unknown. Other areas of interest include the potential anti-diabetic effects of taurine and the role of beta-adrenoceptor regulation in diabetic induced cardiomyopathy.

Representative Publications

For a complete list of publications by Thomas E. Tenner in PubMed, click here

Dr. Thomas E. Tenner, Jr.