TTUHSC School of Medicine
Physiology

Cell Physiology and Molecular Biophysics

LORENZ OTTO LUTHERER, M.D., Ph.D.

Professor of Physiology and Internal Medicine



CURRICULUM VITAE

TITLE:

Professor (Tenured)
Department of Cell Physiology and Molecular Biophysics, 1986 - present
Professor of Internal Medicine, 1986 - present
Texas Tech University Health Sciences Center Lubbock, Texas
Member, Graduate Faculty, Dept. of Physiology, 1976 - present
Director, Center for Cardiovascular Disease and Stroke, 2004 - present
Medical Director, School of Medicine Clinical Research Center, 2009 - present
ADDRESS:

Department of Cell Physiology and Molecular Biophysics
Texas Tech University Health Sciences Center
3601 4th St & Indiana, STOP 6551
Lubbock, Texas 79430-6551
(806)-743-2532
Lorenz.Lutherer@ttuhsc.edu
EDUCATION:

FELLOWSHIPS:

MEDICAL LICENSURE: Texas, 1977 - present
PROFESSIONAL EXPERIENCE:

HONORS:

MAJOR GRANTS AND AWARDS:

REPRESENTATIVE SOCIETY MEMBERSHIPS and OFFICIAL POSITIONS:

EDITORIAL REVIEW:

RESEARCH GRANT REVIEW:

CONSULTANT: American Association for Accreditation of Laboratory Animal Care (AAALAC), 1996 - 1999
VISITING PROFESSOR:

COURSES TAUGHT:

MAJOR COMMITTEE SERVICE:

GRADUATE SCHOOL/DISSERTATION COMMITTEES:

Major Advisor

Committee Member

Mentor

SYMPOSIA:

COMMUNITY ACTIVITIES:

PUBLICATIONS

SELECTED PAPERS (In peer-reviewed journals):

  1. Lutherer LO, Nugent KM, Schoettle BW, Cummins MJ, Raj R, Birring SS and Jumper CA. Preliminary results suggest prevention of progression of idiopathic pulmonary fibrosis by treatment with low-dose, oral interferon alpha. In Press in Thorax, 2010.
  2. Viatchenko-Karpinski S, Terentyev D, Jenkins LA, Lutherer LO, and Gyorke S. Synergistic interactions between Ca2+ entries through L-type Ca2+ channels and Na+-Ca2+ exchanger in normal and failing rat heart. J. Physiol. 567:493-504, 2005.
  3. Gervitz LM, Lutherer LO, Hamilton, ME, and Fowler JC. Lack of central effects of peripherally administered adenosine A1 agonists on synaptic transmission in the rat hippocampus. Brain Research, 951:141-145, 2002.
  4. Nguyen, HX, Tenner, TE, Jenkins, LA, Hansen, HA, and Lutherer, LO. A city-wide evaluation of identification of risk factors for cardiovascular disease in emergency department patients complaining of chest pain. J. Texas Med. 98:82-88, 2002.
  5. Gervitz LM, Lutherer LO, Davies DG, Pirch JH, and Fowler JC. Adenosine induces the initial hypoxic-ischemic depression of synaptic transmission in the rat hippocampus in vivo. Amer. J. Physiol. 280:R639-R645,2001. 2000
  6. Shi B, Heavner JE, Wang MJ, Lutherer LO, McIntyre DC, and Reigel CE: Marked Differences in Sensitivity to the Cardiotxicity of Cacaine in Genetically Fast- and Slow-Amygdala Kindling Rats. FASEB J. 11:A205, 1997.
  7. Chen CH, Williams JL and Lutherer LO: Cerebellar lesions alter autonomic responses to transient, isovolemic changes in arterial pressure. Clinical Autonom. Res. 4:263 - 272, 1994.
  8. Williams, JL and Lutherer LO. Fastigial pressor response observed during an operation on a patient with cerebellar bleeding - anatomical review and clinical significance. Letter to the Editor. Neurosurg. 34:379 - 380, 1994.
  9. Cooper MW, Mitchell R, Lutherer LO and Lust RM: Electrocardiography and postextrasystolic potentiation: Utilization of the two methods to predict postrevascularization segmental myocardial function. Clin Cardiol 14:243 - 248, 1991.
  10. Lutherer L0, Everse SJ and Williams JL: Neurons of the rostral fastigial nucleus are responsive to cardiovascular and respiratory challenges. J Autonom Nerv Syst 27:101 - 112, 1989.
  11. Williams JL, Everse SJ and Lutherer LO: Stimulating fastigial nucleus alters central mechanisms regulating phrenic activity. Respirat Physiol 76:215 - 228, 1989.
  12. Spring B, Chiodo J, Harden M, Bourgeois M, Mason JD and Lutherer LO: Psychobiological effects of carbohydrates. J Clin Psychiatry 50[Suppl. 5,] 27 - 33, 1989.
  13. McCann JC, Heird JC, Bell RW and Lutherer LO: Normal and more highly reactive horses. II: Effect of handling and reserpine of the cardiac response to stimuli. Appl Animal Behav Sci 19:219 - 226, 1988.
  14. McCann JC, Heird JC, Bell RW and Lutherer LO: Normal and more highly reactive horses. I: Heart rate, respiratory rate and behavioral observations . Appl Animal Behav Sci 19:201 - 214, 1988.
  15. Stanton MW, Cooper MW, Voda J, Lust RM, Lutherer LO and Feola M: "Isolength" post-extrasystolic potentiation as a predictor of functional restoration following surgical revascularization for acute myocardial ischemia. Cathet and Cardiovasc Diagnosis 12:381 - 385, 1986.
  16. Williams Jl and Lutherer LO: Inhibitory effects of cerebellar lesions on respiration in the spontaneously breathing, anesthetized cat. Brain Res 399:224 - 231, 1986.
  17. Cooper MW, Lutherer LO, Stanton MW and Lust RM: Postextrasystolic potentiation: Regional wall motion before and after revascularization. Am Heart J 111:334 - 339, 1986.
  18. Cooper MW, Lutherer LO, Stanton MW and Lust RM: Postextrasystolic potentiation: Analysis of methods of induction. Am Heart J 111:330 - 333, 1986.
  19. Lutherer L0 and Williams JL: Stimulating fastigial nucleus pressor region elicits patterned respiratory responses. Amer J Physiol 19:R418 - R426, 1986.
  20. Chen CH, O'Leary EO, Janssen HF and Lutherer LO: Changes in ambient temperature alter the blood pressure response to endotoxin and the effectiveness of naloxone. Circ Shock 16:185 - 193, 1985.
  21. Schoenfeld AD, Lox CD, Chen CH and Lutherer LO: Pain threshold changes induced by acute exposure to altered ambient temperature. Peptides 6(Suppl. 1):19 - 22, 1985.
  22. Lust RM, Lutherer LO and Cooper MW: Applicability of echocardiography in volume determination in experimental animals. J Appl Physiol 56:1670 - 1674, 1984.
  23. Lutherer L0: Hormonal influences on resistance to cold. In: "Steffansson's Friendly Arctic" (Folk GE Jr, ed). The Univ of Iowa Press, 149 - 170, 1984.
  24. Messiha FS and Lutherer LO: Gender and propranolol-ethanol interactions. Neurobehav Tox Teratol 5:255 - 257, 1983.
  25. Lutherer L0, Smith AL, Chen CH, O'Leary EL and Lutherer BC: The effect of angiotensin and vasopressin blockade separately and in combination with cerebellectomy on recovery from hemorrhagic hypotension. Circ Shock 10:329 - 340, 1983.
  26. Lutherer L0, Lutherer BC, Dormer KJ, Janssen HF and Barnes CD: Bilateral lesions of the fastigial nucleus prevent the recovery of blood pressure following hypotension induced by hemorrhage or administration of endotoxin. Brain Res 269:251 - 257, 1983.
  27. Janssen HF and Lutherer LO: Influence of the central nervous system on arterial pressure during endotoxin shock. Am J Physiol 13:H178 - H185, 1983.
  28. Lust RM, Lutherer LO, Gardner ME and Cooper MW: Postextrasystolic potentiation and contractile reserve: requirements and restrictions. Am J Physiol 12:H990 - H997, 1982.
  29. Lang IM, Strahlendorf JC, Strahlendorf HK, Lutherer LO and Barnes CD: Investigations of the preferential reduction in drinking behavior of opiate antagonists. Proc West Pharmacol Soc 25:293 - 297, 1982.
  30. Cooper MW, Lutherer LO and Lust RM: Postextrasystolic potentiation and echocardiography: the effects of varying basic heart rate, extrasystolic coupling interval and postextrasystolic interval. Circulation 66:771 - 776, 1982.
  31. Lang IM, Strahlendorf JC, Strahlendorf HK, Lutherer LO and Barnes CD: The effects of chronic administration of naltrexone on appetitive and water exchange in rats. Pharmacol Biochem Behav 16:909 - 913, 1982.
  32. Janssen HF, Pugh JL and Lutherer LO: Reduced ambient temperature blocks the ability of naloxone to prevent endotoxin-induced hypotension. Adv Shock Res 7:117 - 124, 1982.
  33. Houck PC and Lutherer LO: Adrenal blood flow during hemorrhagic hypotension. Am JPhysiol: Heart and Circulatory Physiology 10:H872 - H877, 1981.
  34. Janssen HF, Lutherer LO and Barnes CD: An observed pressor role of the cerebellum during endotoxin shock in the dog. Am J Physiol 240:H368 - H374, 1981.
  35. Janssen HF and Lutherer LO: Ventriculocisternal administration of naloxone protects against severe hypotension during endotoxin shock. Brain Res 194:608 - 612, 1980.
  36. Britton SL, Lutherer LO and Davies DG: The effect of cerebral extracellular fluid acidity on total and regional cerebral blood flow. J Appl Physiol: Respirat Environ Exercise Physiol 47:818 - 826, 1979.
  37. Lutherer L0, Fregly MJ, Tyler PE and Dasler R: Reversal by theophylline of some changes characteristically accompanying hypothyroidism in rats. Pharmacology 17:21 - 31, 1978.
  38. Blatteis CM and Lutherer LO: Effect of altitude exposure on thermoregulatory response of man to cold. J Appl Physiol 41:848 - 858, 1976.
  39. Fregly MJ, Nelson Jr EL, Resch GE, Field FP and Lutherer LO: Reduced b-adrenergic responsiveness in hypothyroid rats. Am J Physiol 229:916 - 924, 1975.
  40. Fregly MJ, Lutherer LO and Tyler PE: Effect of chronic exposure to cold, hypoxia and both combined on water exchange in rats. Aerosp Med 45:1223 - 1231, 1974.
  41. Blatteis CM and Lutherer LO: Reduction by moderate hypoxia of the calorigenic action of catecholamines in dogs. J Appl Physiol 36:337 - 339, 1974.
  42. Blatteis CM and Lutherer LO: Cold induced thermogenesis in dogs: its reduction by moderate hypoxia. J Appl Physiol 35:608 - 612, 1973.
  43. Fregly MJ, Lutherer LO and Tyler PE: Variation of both ambient temperature and duration of cold exposure on water intake following removal from cold. Environ Physiol 96 - 100, 1972.
  44. Lutherer L0, Fregly MJ and Anton AH: An interrelationship between theophylline and catecholamines in the hypothyroid rat acutely exposed to cold. Fed Proc 28:1238 - 1242, 1969.
  45. Wunder CC, Lutherer LO and Dodge CH: Survival and growth of organisms during life- long exposure to high gravity. Aerosp. Med. 34:5 - 11, 1963.
  46. Lutherer LO, Wunder CC, Moressi WJ and Dodge CH: Implanted tumor growth in mice exposed to continuous centrifugation. Nature 201:303 - 304, 1964.
  47. Wunder CC and Lutherer LO: Influence of chronic exposure to increased gravity upon growth and form of animals. Int Rev Gen Exp Zool 1:333 - 416, 1964.
  48. Blatteis CM and Lutherer LO: Fatty tissue changes in rats with acclimatization to high altitude. Science 149:1383 - 1385, 1965.
  49. Lutherer L0, Fregly MJ and Anton AH: An interrelationship between theophylline and catecholamines in the hypothyroid rat acutely exposed to cold. Fed Proc 28:1238 - 1242, 1969.
  50. Lutherer L0, Fregly MJ, Burns AH and Lutherer BC: Effect of ultracentrifugal fractions of rat renal homogenates on uptake and binding of 131 I by porcine thyroid slices in vitro and rat thyroid glands in vivo. In: Further Advances in Thyroid Research (Fellinger LK, Hofer R, eds), G Gistel and Co, Vienna, 943 - 955, 1971.

MANUSCRIPTS IN PREPARATION

  1. Lutherer LO, Nugent KM, Schoettle BW, Cummins MJ, Raj R, Birring SS and Jumper CA. Preliminary results suggest prevention of progression of idiopathic pulmonary fibrosis by treatment with low-dose, oral interferon alpha. In preparation for submission to J. Invest. Med.
  2. Lutherer LO, Harvey BJ, and Purdom AR. Interruption of the olivocerebellar tract alters reflex cardiorespiratory responses to hypoxia and hypercapnia. Amer. J. Physiol.
  3. Lutherer LO and Purdom AR. Harmaline-induced lesions in the cerebellum alter cardiovascular baroreceptor reflex responses. Amer. J. Physiol.

BOOKS

Lutherer LO and Simon MS: Targeted: The anatomy of an animal rights attack. University of Oklahoma Press, 1992.

RECENT ABSTRACTS:

  1. Lutherer LO, Cummins JM, Cummins MJ, Schoettle BW and CA Jumper. Preliminary results suggest prevention of progression of Idiopathic Pulmonary Fibrosis by treatment with low-dose, oral interferon alpha. J. Investigational Medicine, 54:S252, 2006.
  2. Lutherer LO, Hansen PA and BJ Harvey. Inferior olive lesions reduce the ventilatory response to hypoxia and reverse the augmented ventilatory response observed after destroying cerebellar Purkinje cells. FASEB J., 19:A465, 2005.
  3. Lutherer, LO, RM Bliss and BJ Harvey. Inferior olive lesions reverse the augmented ventilatory response to 10% CO2 observed after destroying Purkinje cells in the cerebellum. FASEB J. 18:A1062, 2004.
  4. Viatchenko-Karpinski S, Terentyev D, Benkusky N, Terentyeva R, Gyorke I, Jenkins LA, Valdivia H, Lutherer LO, Gyorke S. Biphasic Changes In Cardiac EC Coupling In Rats Undergoing Chronic Adrenergic Stimulation. 48th Annual Meeting of the Biophysical Society, Baltimore, Maryland, February 14-18, 2004. Biophys. J, v. 86(1), p.66a.
  5. Terentyev D, Viatchenko-Karpinski S, Gyorke I, Terentyeva R, Harvey B, Bliss R, Jenkins LA, Lutherer LO, Gyorke S. PKA Phosphorylation And RyR-FKBP12.6 Interactions Studied In A Permeabilized Cardiac Myocytes Preparation. 48th Annual Meeting of the Biophysical Society, Baltimore, Maryland, February 14-18, 2004. Biophys. J, v. 86(1), p.66a.
  6. Lutherer, LO and BG Jones. Developing on-line evaluations of medical school basic science courses and clinical clerkships: A one-year review. AAMC Annual Meeting, Washington D.C., 2003.
  7. Harvey BJ, Nash MC, and Lutherer LO. Interruption of the olivocerebellar tract augments the ventilatory response to hypercapnia (10% CO2). FASEB J. 2003.
  8. Lutherer, LO and Jones, BG.  Developing on-line evaluations of medical school basic science courses and clinical clerkships.  AAMC National meeting, Nov 2002.
  9. Harvey BJ, Purdom AR, and Lutherer LO. Temporal nature of changes in cardiorespiratory responses to hypoxia and hypercapnia after interruption of the olivocerebellar tract. FASEB J. 16:A811, 2002.
  10. Lutherer LO, Purdom AR, Thigpen MA, and Harvey BJ. Changes in reflex cardiorespiratory responses to hypercapnia and hypoxia due to harmaline-induced death of cerebellar Purkinje cells. FASEB J. 15:A, 2001.
  11. Lutherer LO, Gervitz LM, and Purdom AR. The exaggerated decrease in heart rate in response to increased pressure after harmaline-induced cerebellar lesions changes to a reduced decrease with time and is only minimally altered by repeated harmaline administration. FASEB J. 14:A67, 2000.
  12. Gervitz LM, Lutherer LO, Davies DG, Pirch JH, and Fowler JC. The use of an in vivo rat model to study the effects of moderate hypoxia on hippocampal electrophysiolgy. FASEB J. 14:A634, 2000.
  13. Gervitz LM, Lutherer LO, Davies DG, Pirch JH, and Fowler JC. The role of adenosine in the early synaptic response to hypoxia in the rat hippocampus in vivo. Soc. for Neurosci. 2000.
  14. Lutherer LO and Purdom AR. Reversal of functional deficits resulting from harmaline-induced cerebellar lesions. FASEB J. 13:LB77, 1999.
  15. Purdom AR, Melton MS, and Lutherer, LO: Harmaline-induced cerebellar lesions alter the baroreceptor reflex response to increased pressure by disinhibiting vagal output to the heart. FASEB J. 12:, 1998
  16. Lutherer LO: Cerebellar Regulation of Cardiovascular and Respiratory Function. FASEB J. 11:A658, 1997.
  17. Lutherer LO, Everse SJ and Lutherer BC: Respiratory response to carbon dioxide is decreased by acute lesions of the fastigial nucleus (FN). FASEB Journ. 2:A511, 1988.
  18. Lutherer LO and Orem J: Cerebellar respiratory related neurons are posturally modulated and change activity across sleep/wakefulness states. FASEB J. 9:A428, 1995.





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