Jose F. Perez-Zoghbi
For our research we use "living" lung slices prepared from animals in combination with molecular, pharmacological, biochemical and imaging tools including high-speed confocal microscopy.
By studding simultaneously contraction and intracellular Ca2+ signaling in lung slices we demonstrated that the contraction of airways and arteries is regulated by the frequency of intracellular Ca2+ oscillations occurring in their smooth muscle cells. Calcium independent pathways involving the phosphorylation of a number of proteins are also important regulators of smooth muscle contraction and are being studied in our laboratory.
We are currently exploring several models of airway and pulmonary vascular disease to understand the mechanisms of increased airway and vascular smooth muscle contraction.
My teaching is focused on pulmonary physiology as well as basic mechanisms of cell signaling and cytoskeleton dynamics.
Our research is important to understand basic cellular mechanisms underlying lung diseases that affect smooth muscle contractility such as asthma, COPD (Chronic Obstructive Pulmonary Disease), pulmonary hypertension and pulmonary edema.
Perez-Zoghbi, J.F.; Karner, C.; Ito, S.; Shepherd, M; Alrashdan, Y.; and Sanderson, MJ (2008): Ion channel regulation of intracellular calcium and airway smooth muscle function. Pulm Pharmacol Ther, 21: In press.
Perez-Zoghbi, J.F.; Mayora, A.; Ruiz, M-C. and Michelangeli, F. (2008): Heterogeneity of acid secretion induced by carbachol and histamine along the gastric gland axis and its relationship to [Ca2+]i. Am J Physiol Gastrointest Liver Physiol. 295:G671-81
Perez-Zoghbi, J.F. and Sanderson, M.J. (2007): Endothelin-induced contraction of bronchiole and pulmonary arteriole smooth muscle cells is mediated by intracellular Ca2+ oscillations. Am J Physiol Lung Cell Mol Physiol. 293: L1000-L1011
Perez, J.F. and Sanderson, M.J. (2005): The contraction of smooth muscle cells of intrapulmonary arterioles is determined by the frequency of Ca2+ oscillations induced by 5-HT and KCl. J. Gen. Physiol. 125: 555-67
Perez, J.F. and Sanderson, M.J. (2005): The frequency of calcium oscillations induced by 5-HT, ACH, and KCl determine the contraction of smooth muscle cells of intrapulmonary bronchioles. J. Gen. Physiol. 125: 535-53
Perez, J.F.; Chemello, M.E.; Liprandi F; Ruiz, M-C.; Michelangeli, F. (1998): Oncosis in MA104 cells is induced by rotavirus infection through an increase in intracellular Ca2+ concentration. Virology 252: 17-27.
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Last update: Feb-16-2009