Research: Center of Excellence for Infectious Diseases
Principal Investigators
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Haoquan Wu, Ph.D.Assistant Professor of the Center of Excellence for Infectious DiseasesDepartment of Biomedical Sciences |
Research Interest
miRNAs are a class of small RNAs around 22 nucleotides long, that have emerged as critical regulators that modulate almost all biological processes involving gene expression. Alterations in miRNA expression have been implicated in various human diseases including cancer. The major interest of the Wu lab is to understand how miRNAs are generated and degraded, and also how these processes are regulated during T cell differentiation and virus infection. And also our previous studies suggest that the sequence of a given miRNA is not fixed as annotated in the miRBase, but show considerable variations at the ends. We are assessing the functional significance of the variant miRNA forms and the mechanism of their generation.
Dr. Wu obtained his Ph.D. degree from Fudan University, Shanghai, China and received postdoctoral training at UCLA and the Immune Disease Institute, Harvard Medical School.
- Ongoing Projects
Publications
Staff
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