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Hematology Oncology Recent Publications

Fellows Publications

Risk of hematological toxicities in patients with myeloproliferative neoplasms treated with ruxolitinib: a systematic review and meta-analysis of randomized controlled trials. Kyaw Z. Thein, Henry P. Igid, Rachana Yendala, Myo H. Zaw, Miguel Quirch, Lukman Tijani, Donald Quick.  Submitted to 23rd NCCN Annual Conference: Improving the Quality, Effectiveness, and Efficiency of Cancer Care, 2017
Efficacy of lapatinib and capecitabine combination therapy in brain metastases from HER-2 positive metastatic breast cancer: A systematic review and meta-analysis. Kyaw Z. Thein, Myo H. Zaw, Rachana Yendala, Henry P. Igid, Chatree Chai-Adisaksopha, Fred Hardwicke, Sanjay Awasthi, Saba Radhi. Accepted to 40th San Antonio Breast Cancer Symposium, 2017
Risk of health-related quality of life events from pain and fatigue among patients with hormone receptor-positive HER-2 negative metastatic breast cancer treated with CDK 4/6 inhibitor. Myat M. Han, Kyaw Z. Thein, Myo H. Zaw, Aung Tun, Paul D’Cunha, Fred L. Hardwicke, Catherine Jones. Accepted to ASCO Palliative and Supportive Care in Oncology Symposium: Patient-centered Care across the Cancer Continuum, 2017
A novel function of SMC1 as a transporter of xenobiotics. Rachana Yendala, Lukman Tijani, Kyaw Zin Thein, Henry Palangdao Igid, Mohamed Shanshal, Sanjay Awasthi, Fred L. Hardwicke. 2017 ASCO Annual Meeting. DOI: 10.1200/JCO.2017.35.15_suppl.e14107 Journal of Clinical Oncology 35, no. 15
Risk of infectious, hematological, and gastrointestinal side effects in patients treated with ibrutinib: A systematic review and meta-analysis of randomized controlled trials. Myo H. Zaw, Kyaw Z. Thein, Aung M. Tun, Lukman Tijani, Elizabeth Guevara. 2017 ASCO Annual Meeting. DOI: 10.1200/JCO.2017.35.15_suppl.e18265 Journal of Clinical Oncology 35, no. 15
Risk of gastrointestinal and hepatic toxicities in patients with hormone receptor-positive HER2-negative breast cancer treated with CDK 4/6 inhibitors: A systematic review and meta- analysis of randomized controlled trials Aung Myint Tun, Kyaw Zin Thein, Yu Yu Thar, Asha Nayak, Elizabeth Guevara. 2017 ASCO Annual Meeting. DOI: 10.1200/JCO.2017.35.15_suppl.e18284 Journal of Clinical Oncology  35, no. 15
Side Effects of Immune Checkpoint Therapy in Cancer Patients Visiting the Emergency Department of a Comprehensive Cancer Center Myint A. Win, Kyaw Z. Thein, Aiham Qdaisat, Myat M. Han, Sai-Ching J. Yeung NCCN 22nd Annual Conference 2017: Improving the Quality, Effectiveness, and Efficiency of Cancer Care
Low- Molecular Weight Heparins (LMWH) Versus Vitamin K Antagonists (VKAs) in the Treatment and Secondary Prevention of Cancer-Associated Venous Thromboembolism (VTE): A Systematic Review and Meta-Analysis of Randomized Controlled Trials (RCTs) Kyaw Zin Thein, Lukman Tijani, Thein Hlaing Oo 58th American Society of Hematology (ASH) Annual Meeting and Exposition Blood 128(22):1180, http://www.bloodjournal.org/content/128/22/1180, 11/2016. e-Pub 11/2016.
Risk of Bleeding from Primary Thromboprophylaxis (PTP) in Patients with Solid Cancer Receiving Chemotherapy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials (RCT) Kyaw Zin Thein, Aung Myint Tun, Sai-Ching J Yeung, Thein Hlaing Oo 58th American Society of Hematology (ASH) Annual Meeting and Exposition Blood 128(22):3820, http://www.bloodjournal.org/content/128/22/3820, 11/2016. e-Pub 11/2016.
A Systematic Review and Meta-Analysis of Randomized Controlled Trials (RCT) in Ambulatory Thromboprophylaxis (ATP) in Patients with Lung Cancer Receiving Chemotherapy Kyaw Zin Thein, Sai-Ching J Yeung, Thein Hlaing Oo 58th American Society of Hematology (ASH) Annual Meeting and Exposition Blood 128(22):3825, http://www.bloodjournal.org/content/128/22/38225, 12/2016. e-Pub 11/2016.
Association between Abdominal Adiposity, Muscle Mass, and Metabolic Syndrome in Survivors of Testicular Germ Cell Cancer Kyaw Zin Thein, William Osai, Shi-Ming Tu, Lance C. Pagliaro, Jeri Kim, Sai-Ching J. Yeung American Society of Clinical Oncology (ASCO) 2016 palliative care in oncology symposium Journal of Clinical Oncology 34(26_suppl):250-250, October 2016 DOI: 10.1200/jco.2016.34.26_suppl.250
Primary Thromboprophylaxis (PTP) in ambulatory patients with lung cancer receiving chemotherapy: A systematic review and meta- analysis of randomized controlled trials (RCTs) Kyaw Zin Thein, Sai-Ching Jim Yeung, Thein Hlaing Oo Accepted to Asia-Pacific Journal of Clinical Oncology DOI:10.1111/ajco.12770
A Rare Case of Primary Esophageal Diffuse Large B Cell Lymphoma Presenting with Tracheoesophageal Fistula and ReviewJirapat Teerakanok, Judy Park DeWitt, Edna Juarez, Kyaw Zin Thein, Irfan Warraich Accepted to World Journal of Gastrointestinal Oncology
Acute Symptomatic Hypocalcemia from Immune Checkpoint Therapy-Induced Hypoparathyroidism Myint A. Win, Kyaw Z. Thein, Aiham Qdaisat, Sai-Ching J. Yeung The American journal of emergency medicine, February 2017 DOI: 10.1016/j.ajem.2017.02.048
Pernicious Anemia: Fundamental and Practical Aspects in Diagnosis Aung Myint Tun, Kyaw Zin Thein, Zin War Myint, Thein Hlaing Oo Cardiovascular & hematological agents in medicinal chemistry DOI: 10.2174/1871525715666170203114632
Cancer Immunotherapy-induced Posterior Reversible Encephalopathy Syndrome in an Emergency Department Myint A. Win, Kyaw Z. Thein, Sai-Ching J. Yeung The American journal of emergency medicine 35(4), October 2016 DOI: 10.1016/j.ajem.2016.10.069
Chimeric antigen receptor engineering: a right step in the evolution of adoptive cellular immunotherapy.  Figueroa JA, Reidy A, Mirandola L, Trotter K, Suvorava N, Figueroa A, Konala V, Aulakh A, Littlefield L, Grizzi F, Rahman RL, Jenkins MR, Musgrove B, Radhi S, D'Cunha N, D'Cunha LN, Hermonat PL, Cobos E, Chiriva-Internati M. Int Rev Immunol. 2015 Mar;34(2): 154-87 doi: PMID 25901860
Nuclear Export as a Novel Therapeutic Target: The CRM1 Connection. Lu C, Figueroa JA, Liu Z, Konala V, Aulakh A, Verma R, Cobos E, Chiriva-Internati M, Gao W. Curr Cancer Drug Targets. 2015 PMID: 26324128
Treatment of Hepatic Epithelioid Hemangioendothelioma: Finding Uses for Thalidomide in a New Era of Medicine.  Soape MP, Verma R, Payne JD, Wachtel M, Hardwicke F, Cobos E. Case rep Gastrointest Med. 2015. Epub 2015 Jun 17. PMID 26167310
Sex-driven differences in immunological responses: challenges and opportunites for the immunotherapies of the third millennium. Mirandola L, Wade R, Verma R, Pena C, Hosiriluck N, Figueroa JA, Cobos E, Jenkins MR, Chiriva-Internati M. Int Rev Immunol. 2015 Mar;34(2):134-42. doi: PMID 25901858
The role of human papilloma virus (HPV) infection in non-anogential cancer and the promise of immunotherapy Cobos C, Figueroa JA, Mirandola L, Colombo M, Summers G, Figueroa A, Aulakh A, Konala V, Verma R, Riaz J, Wade R, Saadeh C, Rahman RL, Pandey A, Radhi S, Nguyen DD, Jenkins M, Chiriva-Internati M, Cobos E. Int Rev Immunol. 2014 Oct;33(5):383-401. doi:Epub 2014 May 8. PMID 24811210

Faculty Publications

CHRONIC MYELOGENOUS LEUKEMIA BCR/ABL POSITIVE COMPLICATING A PREGNANCY AUTHORS (LAST NAME, FIRST NAME): Juarez Ramirez Tello, Edna Maritza 1; Sultan, Anita 1; Khan, Saad 3; Tijani, Lukman. Abstract accepted for presentation at Southern Society for Clinical Investigation Annual Meeting (2017)
 Low- Molecular Weight Heparins (LMWH) Versus Vitamin K Antagonists (VKAs) in the Treatment and Secondary Prevention of Cancer-Associated Venous Thromboembolism (VTE): A Systematic Review and Meta-Analysis of Randomized Controlled Trials (RCTs)  Kyaw Zin Thein, Lukman Tijani and Thein H. OoBlood 2016 128:1180; An oral presentation at the Annual ASH meeting in December, 2016. 
Differential Modulation of Glutathione Metabolism in Adeno and Squamous NSCLC by 2HF: Tijani L, Awasthi S. A  Poster Presentation at the IASLC 2016, Multidisciplinary Symposium in Thoracic Oncology September, 2016.
Figarola J, Singhal J, Tompkins J, Rogers G, Warden C, Horne D, Riggs , Awasthi S, and Singhal SS. (2015) SR4 uncouples      mitochondrial oxidative-phosphorylation, modulates AMPK-mTOR signaling, and inhibits proliferation of HepG2 hepatocarcinoma cells. J Biol Chem 290:  30321-30341(PMID: 26534958). 
Yadav S, Singhal J, Eroglu Z, Berz D, Singhal  SS, Awasthi YC, and Awasthi S. (2016) Simultaneous targeting of multiple      survival pathways in breast cancer.
 Suarez, M.G. MD; Sultan A. MD; Verma R. MD; Hardwicke F. MD.  Can elevated coagulation factor VIII cause thrombosis?  Journal of Investigative Medicine.  2016, Feb; 64(2):  707-708.
 Sultan, A. MD; Ibilibor C. MD; Suarez M. MD; Shanshal M. MD; Hardwicke F. MD.  Small cell cancer with a rare presentation as Bladder cancer.  Journal of Investigative Medicine.  2016, Feb; 64(2):  562
Singhal SS, Singhal J, Figarola JL, Riggs A,  Horne D, and Awasthi S. (2015) 2'-Hydroxyflavanone: A promising molecule      for kidney cancer prevention. Biochem Pharmacol 96: 151-158 (PMID:  25957660).
 Singhal,  S.S., Figarola, J., Singhal, J., Rahbar, S., Awasthi, S., and Horne, D.  (2015) Role of COH-SR4 in diabetes: glutathione-linked enzymes and oxidative stress.  Endocrine Reviews  36: Abs # 27.
 Singhal SS, Singhal J, Figarola JL, Horne D,  and Awasthi S. (2015) RLIP76 targeted therapy for kidney cancer. Pharm Res      32:3123–3136 (PMID: 26021465).
 Singhal SS, Singh SP, Singhal P, Horne D,  Singhal J, and Awasthi S. (2015) Antioxidant role of glutathione s-transferases: 4-hydroxynonenal, a key molecule in stress-mediated signaling. Toxicol Appl Pharmacol 289: 361-370 (PMID: 26476300). 
Wurtzel JG, Lee S, Singhal SS, Awasthi S, Ginsberg MH, and Goldfinger LE. (2015) RLIP76 regulates Arf6-dependent cell spreading and migration by linking ARNO with activated R-Ras at  recycling endosomes.  Biochem Biophys  Res Commun 467: 785-791(PMID: 26498519).
 Figarola J, Singhal J, Tompkins J, Rogers G, Warden C, Horne D, Riggs , Awasthi S, and Singhal SS. (2015) SR4 uncouples      mitochondrial oxidative-phosphorylation, modulates AMPK-mTOR signaling, and inhibits proliferation of HepG2 hepatocarcinoma cells. J Biol Chem 290: 30321-30341(PMID: 26534958). 
Hosiriluck N, Klomjit S, Rassameehiran S, Sutamtewagul G, Tijani L, Radhi S. The Southwest Respiratory and Critical Care Chronicles. Volume 3, No9 (2015) Prognostic factors for mortality with febrile neutropenia in hospitalized patients
Jose A. Figueroa, Adair Reidy, Nicholas D’Cunha, Luke N. D’Cunha, Everardo Cobos, Maurizio Chiriva-Internati et al. Chimeric Antigen Receptor Engineering: A Right Step in the Evolution of Adoptive Cellular Immunotherapy: International Reviews of Immunology,  34:154–187, 2015.
R Verma, J Riaz, L Mirandola, J Figueroa, S Radhi, N. D’Cunha, et al. Galectin-3 inhibition suppresses drug resistance, motility, invasion and angiogenic potential in ovarian cancer. Abstract #132602 Submitted to American Society of Clinical Oncology June 2014
 L Mirandola, J Riaz, R Verma, S Radhi, T Pham, A Aulakh, V Konala, N. D’Cunha et al. Cancer testis antigens: Potential new targets for lung cancer. Abstract Submitted to American Society of Clinical Oncology June 2014
Cobos C, Figueroa J,  Mirandola, L,  Colombo M, Summers G, Figueroa A, Aulakh, A, Konala V, Verma R, Riaz J, Wade R, Saadeh C, Rahman R ,Pandey, A, Radhi S,  Nguyen D, Jenkins M, Chiriva-Internati M, Cobos E May (2014) The Role of Human Papilloma Virus (HPV) Infection in Non-Anogenital Cancer and the Promise of Immunotherapy: A Review.
Panikkath R, Konala V, Panikkath D, Umyarova E, Hardwicke FL. Fatal Clostridium septicum infection in a patient with a hematological malignancy., 27(2): 111-2, April 2014. PubMed Central ID Number: 24688190
H. Maze, V. Konala, S. Omar, A. Mustafa, I. Warraich, N. D'Cunha.  A Rare Case of Adult  Alveolar Synovial habdomyosarcoma (SNRMS): Selected for poster presentation at the Southern Society for Clinical Investigation (SSCI), New Orleans, LA. Feb 2014 
Panikkath R, Radhi S, Yik Lim S, Thankam M, Quattromani F, Jumper C. The Southwest Respiratory and Critical Care Chronicles. Volume 1 Issue 4 (2013) Metastasis of lung cancer through Batson’s plexus: very rare but possible.
N. Dumrongmongcolgul, C. Mankongpaisarnrung, G. Sutamtewagul, N. Hosiriluck, T. Chen, A. Trujillo, N. D’Cunha, K. Nugent, L. Ann Jenkins.  Reactive Thrombocytosis Associated with Acute Myocardial Infarction Following STEMI with Percutanious        Coronary Intervention - A Case Report:  Case Reports in Cardiology; Vol. 2013 (2013),  Article ID 707438. http://dx.doi.org/10.1155/2013/707438
Charles Saadeh, Chad Wade, Jesse Mer, Saba Radhi, Raed Alalawi, Leonardo Mirandola, Yuefei Yu, Apurva Pandy, Diane Nguyen, Lukman Tijani, Nicholas D'Cunha, Fred Hardwicke, Marjorie Jenkins, Cynthia Jumper, Maurizio Chiriva-Internati, Everardo Cobos.  The expressions of Sp17/AKAp4/PTTG1 in Non-small cell lung cancer detected both in serology and tissue student research week. 2013.
L. N. D'Cunha, N. C. D'Cunha, D. Harville, E. Cobos.  Compare the Outcome of Patients with Hematological Malignancies Treated with Allogeneic Stem Cell Transplant in Patients Age over 50 Conditioned with Reduce Intensity Regimens with those under 50 Conditioned with Standard Intensity Regimen in a Rural University Hospital – A Single Institution Experience. Published online-on the December 2013 ASH abstracts site.     http://bloodjournal.hematologylibrary.org/site/misc/ash_meeting_abstracts_info.xhtml
Mast cells and the liver again process. Grizzi F, Di Crao G, Laghi L, Hermonat P, Mazzola P, Nguyen DD, Radhi S, Figueroa JA, Cobos E, Annoni G, Chiriva-Internati M. Immun Ageing. 2013 Mar 7;10(1):9.. PMID 23496863
Aging, cancer and cancer vaccines.  Mazzola P, Radhi S. Mirandola L, Annoni G, Jenkins M, Cobos E, Chiriva-Internati M. Immun Ageing. 2012 April 17;9(1)4.. PMID 22510392
Galectin-3C Inhibits Tumor Growth and Increases the Anticancer Activity of Bortezomib in a Murine Model of Human Multiple Myeloma. Mirandola L, Yu Y, Chui K, Jenkins MR, Cobos E, John CM, Chiriva-Internati M. PLoS One. 2011;6(7):e21811. Epub 2011 Jul 13. PMID: 21765917 [PubMed - in process] Free PMC Article Free full text Related citations
Cancer testis antigen, ropporin, is a potential target for multiple myeloma immunotherapy. Chiriva-Internati M, Mirandola L, Yu Y, Jenkins MR, Gornati R, Bernardini G, Gioia M, Chiaramonte R, Cannon MJ, Kast WM, Cobos E. J Immunother. 2011 Jul-Aug;34(6):490-9. PMID: 21654522 [PubMed - in process] Related citations
Notch-ing from T-cell to B-cell lymphoid malignancies. Mirandola L, Comi P, Cobos E, Kast WM, Chiriva-Internati M, Chiaramonte R. Cancer Lett. 2011 Sep 1;308(1):1-13. PMID: 21652011 [PubMed - in process] Related citations
Genistein inhibited proliferation and induced apoptosis in acute lymphoblastic leukemia, lymphoma and multiple myeloma cells in vitro. Li W, Frame LT, Hoo KA, Li Y, D'Cunha N, Cobos E. Leuk Lymphoma. 2011 Jul 13. [Epub ahead of print] PMID: 21749310 [PubMed - as supplied by publisher] Related citations
Sperm protein 17: clinical relevance of a cancer/testis antigen, from contraception to cancer immunotherapy, and beyond. Chiriva-Internati M. Int Rev Immunol. 2011 Apr-Jun;30(2-3):138-49. PMID: 21557640 [PubMed - in process] Related citations
Cancer testis antigens: novel biomarkers and targetable proteins for ovarian cancer. Mirandola L, J Cannon M, Cobos E, Bernardini G, Jenkins MR, Kast WM, Chiriva-Internati M. Int Rev Immunol. 2011 Apr-Jun;30(2-3):127-37. PMID: 21557639 [PubMed - in process] Related citations
Prospects and challenges for immunotherapy of ovarian cancer--what can we learn from the tumor microenvironment? Chiriva-Internati M, Cobos E, Cannon MJ. Int Rev Immunol. 2011 Apr-Jun;30(2-3):67-70. PMID: 21557634 [PubMed - in process] Related citations
Understanding the cross-talk between ovarian tumors and immune cells: mechanisms for effective immunotherapies. Chiriva-Internati M, Mirandola L, Kast WM, Jenkins MR, Cobos E, Cannon MJ. Int Rev Immunol. 2011 Apr-Jun;30(2-3):71-86. PMID: 21557635 [PubMed - in process] Related citations
Identification of AKAP-4 as a new cancer/testis antigen for detection and immunotherapy of prostate cancer. Chiriva-Internati M, Yu Y, Mirandola L, D'Cunha N, Hardwicke F, Cannon MJ, Cobos E, Kast WM. Prostate. 2011 Apr 25. doi: 10.1002/pros.21400. [Epub ahead of print] PMID: 21520158 [PubMed - as supplied by publisher] Related citations
Dendritic cell vaccination against ovarian cancer--tipping the Treg/TH17 balance to therapeutic advantage? Cannon MJ, Goyne H, Stone PJ, Chiriva-Internati M. Expert Opin Biol Ther. 2011 Apr;11(4):441-5. Epub 2011 Jan 28. Review. PMID: 21271951 [PubMed - indexed for MEDLINE] Related citations
Nanotechnology and human health: risks and benefits. Cattaneo AG, Gornati R, Sabbioni E, Chiriva-Internati M, Cobos E, Jenkins MR, Bernardini G. J Appl Toxicol. 2010 Nov;30(8):730-44. doi: 10.1002/jat.1609. Review. PMID: 21117037 [PubMed - indexed for MEDLINE] Related citations
Ukrain affects pancreas cancer cell phenotype in vitro by targeting MMP-9 and intra-/extracellular SPARC expression. Funel N, Costa F, Pettinari L, Taddeo A, Sala A, Chiriva-Internati M, Cobos E, Colombo G, Milzani A, Campani D, Dalle-Donne I, Gagliano N. Pancreatology. 2010;10(5):545-52. Epub 2010 Oct 23. PMID: 20975318 [PubMed - indexed for MEDLINE] Related citations
Cancer testis antigen vaccination affords long-term protection in a murine model of ovarian cancer. Chiriva-Internati M, Yu Y, Mirandola L, Jenkins MR, Chapman C, Cannon M, Cobos E, Kast WM. PLoS One. 2010 May 12;5(5):e10471. PMID: 20485677 [PubMed - indexed for MEDLINE] Free PMC Article Free full text Related citations
An update on hematological malignancies. D'Cunha N, Cobos E. Tex Med. 2010 Sep 1;106(9):59-63. PMID: 20809446 [PubMed - in process] Related citations
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