John Griswold
John A. Griswold, M.D., FACS
email: john.griswold@ttuhsc.edu
Medical Director, Timothy J Harnar Burn Center,
Executive Director for the Clinical Research Institute (CRI),
Medical Director of Nutrition Support Services,
Medical Director, Enterostomal Therapy,
Co-Director, Advanced Trauma Life Support,
Medical Director, Borden County EMS
Patient Appointments:
Surgery Clinic : 806-743-2388
Clinic Location:
Surgery Clinic: Mop 1, Suite 310, 3502 9th St
Biography:
Born and raised in Casper, Wyoming, Dr. Griswold attended the University of Notre Dame in South Bend, Indiana where he obtained a Bachelor of Science. He then attended Creighton University in Omaha, Nebraska where he obtained his M.D. degree, and then on to Texas Tech for general surgery residency. This was followed by fellowships at the University of Washington in Seattle involving burn, trauma, and critical care. Dr. Griswold returned to Texas Tech in 1992 and developed a busy general surgery practice. He is currently Professor and Medical Director of the Timothy J. Harnar Burn Center. He was the Chair of the Department of Surgery 1997-2016 and Medical Director of the Level 1 Trauma Center (first to be verified in Texas by the state) 2000-2014. Dr. Griswold’s nomination as Chair Emeritus was approved by the Texas Tech University System Board of Regents at the February 2016 meeting. He also holds the position of Vice Chair of Quality Assurance and Performance Improvement as well as Vice Chair of Education in the Department of Surgery. Besides being active in the care of injured and burn patients as well as critically ill surgical patients Dr. Griswold has an interest in patients with complex GI problems, malnutrition, and wounds. In September of 2019, Dr. Griswold was named Executive Director of the Clinical Research Institute. The Institute supports and oversees all clinical research activities through out the Health Sciences Center.
Dr. Griswold has a very busy clinical practice. Although patient care has involved all aspects of general surgery, his entire career has been specifically oriented towards the care of the injured. He was recognized in January 2016 having the Level 1 Trauma Center named for him. His clinical volume is currently focused on care of acutely injured patients especially burn injured from insult to recovery including scar management and aesthetic and functional reconstruction techniques. Most recently this has led to a development of a very comprehensive laser program for scar prevention, removal and reconstruction.
Mirroring his clinical practice and focus on care of the injured, Dr. Griswold’s research has focused on assessment of the pathophysiology of injury and prevention of injuries. He has 93 peer reviewed articles and a multitude of competitive regional and national presentations focusing on the areas of pathophysiology and metabolic effects of injury, wound healing, infection and infection prevention, and the assessment of devices and products that improve healing and prevent scarring.
Dr. Griswold is focusing on curriculum development and the dissemination of practical and theoretic/scientific information to residents and medical students in all aspects of surgery. Much of Dr. Griswold’s current administrative and educational activities center around quality assessment as it pertains to surgery and surgical diseases as well as quality improvement and patient safety improvement protocols. He also is responsible for the Burn Center registry and quality data development, TQIP (Trauma Quality Improvement Program) and NSQIP (National Surgical Quality Improvement Program) for our institution.
Education/Certification:
Fellowship:
Burn Clinical Fellow, University of Washington, Seattle, Washington, 1987-1988
Burn Research Fellow, University of Washington, Seattle, Washington, 1986-1987
Residency:
General Surgery, Texas Tech Health Sciences Center, Lubbock, Texas, 1982-1986
Medical School:
Creighton University, Omaha, Nebraska, 1977-1981
Certification:
American Board of Surgery
American Board of Critical Care
Association of Clinical Research Professionals (ACRP) Clinical Investigator Certification
Research:
Nutrition in critical care
Pseudomonas infection and virulence
Serum specific indicators of severity of injury
Stroma free hemoglobin effect on cytokine production in acute and chronic illness
Primary Investigator:
Sepsis and Trauma. (Phase IIB) - ICOS/Scirex
Severe Acute Pancreatitis (Phase II/III) - ICOS/Parexel
The use of Oxandrolone in severe closed-head injuries. (Phase IV) Investigator Initiated Protocol
Autograft Donor Sites in Burn Patients. (Phase III) Ortec/The Phoenix
Acute Respiratory Distress Syndrome. (Phase II) Suntory/PPD
S-100B protein in severe closed head injuries. Investigator Initiated
Bradykinin & Cytokine Blood Levels in Burn/Trauma Patients. Investigator
Treatment of Acute Lung Injury in the ICU. (Phase II) Eli-Lilly/Omnicare
Treatment of Sepsis in the ICU. (Phase III) ICOS/PPD
Early treatment of Sepsis in the ICU. (Phase I) GlaxoSmithkline/PPD
Enterra Therapy: An emerging treatment option for drug-refractory gastroparesis
499E02-A Phase 2 Study of Recombinant Human Thrombin (rh Thrombin) Administered Using a Spray Applicator in Subjects Undergoing Autologous Skin Grafting Following Burn or Traumatic Skin Injury.
ACCESS: A Controlled Comparison of Eritoran Tetrasodium and Placebo in Patients with Severe Sepsis
A Phase III, Multi-center, Randomized, Evaluation Committee-blinded Study to Assess the Efficacy of Topical Administration of Omiganan 1.0% Gel in Preventing Local Catheter Site Infections and Catheter Colonization in Patients undergoing Central Venous Catheterization.
A Study To Evaluate The Safety And Efficacy Of Fibrin Sealant With 4IU/ML Thrombin Vapor Heated, Solvent/Detergent Treated (FS 4IU VH S/D) To Adhere Tissues And Improve Wound Healing
Analyzing the antibiotic resistance profile of bacterial isolates obtained from severely burned patients.
Burn Treatment Outcomes: A retrospective study for different protocols.
Relationship of Pseudomonas Aeruginosa virulence factors to clinical outcome of wound infection.
Functional outcome of 80 and 90 year old burn patients.
Trauma Team Activation from the Field
Radiology-Trauma Study
In The News:
Courtney Fromm. KLBK News. Mar 30, 2018. Web. More
ELLYSA HARRIS, Lubbock Online | Lubbock Avalanche-Journal. December 18, 2017. Web. More
Karin McCay - KCBD TV Healthwise - March 2, 2017. More
Karin McCay - KCBD TV Healthwise - October 27, 2016. More
TTUHSC Daily Dose. Suzanna Cisneros. August 8, 2016 More
ELLYSA GONZALEZ, Lubbock Online | Lubbock Avalanche-Journal. Mar 14, 2016. More
Karin McCay - KCBD TV Healthwise - March 8, 2016.
Texas Tech Physicians Medical Minute. October 6, 2014. More
Recent Publications:
Matis TI, Griswold JA. On the Performance of Surgical Teams Displaying Intraoperative Communication Patterns of a High Reliability Organization. Submitted.
Elmassry M, Mudaliar N, Colmer-Hamood J, San Francisco M, Griswold J, Dissanaike S, Hamood A. New markers for sepsis cause by Pseudomonas aeruginosa during burn infection Metabolomics 2020; 16 (3) :40.
Fleming D, Jiang D, Opoku K, Alhaj-Saleh A, Larumbe E, Kesey J, Griswold J, Dissanaike S. Prophylactic Probiotics in Burn Patients: Risk versus Reward Journal of Burn Care & Research 2019; 40 (6) :953-960.
Zhou Y, Zhang Y, Johnson A, Venable A, Griswold J, Pappas D. Detection of Culture-Positive and Culture-Negative Sepsis in Clinical Blood Samples using a Microfluidic Assay for CD64 and CD69 Cell Capture Analytica Chimica Acta 2019; 1062 :110-117.
Elmassry M, Mudaliar N, Kottapalli K, Dissanaike S, Griswold J, Francisco M, Colmer-Hamood J, Hamood A. Pseudomonas aeruginosa alters its transcriptome related to carbon metabolism and virulence as a possible survival strategy in blood from trauma patients mSystems 2019; 4 (4) :eCollection.
Zhou Y, Zhang Y, Johnson A, Venable A, Griswold J, Pappas D. Combined CD25, CD64, and CD69 biomarker panel for flow cytometry diagnosis of sepsis Talanta 2019; 191 :216-221.
Puckett Y, Zhang K, Blasingame J, Lorenzana J, Parameswaran S, Brooks SE, Baronia BC, Griswold J. 2018 July 03. Safest Time to Resume Oral Anticoagulation in Patients with Traumatic Brain Injury. Cureus 10(7): e2920. DOI 10.7759/cureus.2920
Zhang Y, Zhou Y, Li W, Lyons V, Johnson A, Venable A, Griswold J, Pappas D. A Multi-Parameter Affinity Microchip for Early Sepsis Diagnosis Based on CD64 and CD69 Expression and Cell Capture Analytical Chemistry 2018; 90 (12) :7204-7211.
Kim HG, Kesey, JE, Griswold JA. Giant Anorectal Condyloma Acuminatum of Buschke-Lowenstein Presents Difficult Management Decisions. Journal of Surgical Case Reports. 2018; 4, 1-4
Holmes JH 4th, Molnar JA, Carter JE, Hwang J, Cairns BA, King BT, Smith DJ, Cruse CW, Foster KN, Peck MD, Sood R, Feldman MJ, Jordan MH, Mozingo DW, Greenhalgh DG, Palmieri TL, Griswold JA, Dissanaike S, Hickerson WL. A Comparative Study of the ReCell® Device and Autologous Spit-thickness Meshed Skin Graft in the Treatment of Acute Burn Injuries. J Burn Care Res. 2018 May 24. doi: 10.1093/jbcr/iry029. [Epub ahead of print]
Davis CH, Kao LS, Fleming JB, Aloia TA; Texas Alliance for Surgical Quality Collaborative. Multi-Institution Analysis of Infection Control Practices Identifies the Subset Associated with Best Surgical Site Infection Performance: A Texas Alliance for Surgical Quality Collaborative Project. J Am Coll Surg. 2017 Aug 16. pii: S1072-7515(17)31665-4. doi: 10.1016/j.jamcollsurg.2017.07.1054.
Dzvova N, Colmer-Hamood JA, Griswold JA, Hamood AN. Heparinase Is Essential for Pseudomonas aeruginosa Virulence during Thermal Injury and Infection. Infect Immun. 2017 Dec 19;86(1). pii: e00755-17. doi: 10.1128/IAI.00755-17. Print 2018 Jan
Dzvova N, Colmer-Hamood JA, Griswold JA, Hamood AN Isolation and characterization of HepP: a virulence-related Pseudomonas aeruginosa heparinase. BMC Microbiol. 2017 Dec 16;17(1):233. doi: 10.1186/s12866-017-1141-0.
Zhang Y, Li W, Zhou Y, Johnson A, Venable A, Hassan A, Griswold J, Pappas D Detection of sepsis in patient blood samples using CD64 expression in a microfluidic cell separation device. Analyst. 2017 Dec 18;143(1):241-249. doi: 10.1039/c7an01471f.
Kruczek C, Kottapalli KR, Dissanaike S, Dzvova N, Griswold JA, Colmer-Hamood JA, Hamood AN: Major transcriptome changes accompany the growth of Pseudomonas aeruginosa in blood from patients with severe thermal injuries. PLoS One. 11 (3): e0149229. doi: 10.1371/journal. pone.0149229. Epub 2016 Mar 2
McKee D, Eliasson S, Griswold J: Case Report: Congenital Ulnar Drift in a Surgeon. Case Reports in Orthopedics. Vol 2015, Article 135350, 2015
Trivedi U, Parameswaran S, Armstrong A, Burgueno-Vega D, Griswold J, Dissanaike S, Rumbaugh K: Prevalence of Multiple Antibiotic Resistant infections in Diabetic versus Nondiabetic Wounds. Journal of Pathogens. 2014:173053. PMID: 25054067, 2014
Dissanaike S, Abdul-Hamed S, Griswold JA: Variations in Perfusion Over Time as Measured by Portable ICG Fluorescence Indicates Depth of Burn: A Case Series. Journal of Burn Care & Research. 2 (4): 201-205, 2014
Watters C, Deleon K, Trivedi U, Griswold JA, Lyte M, Hampel KJ, Wargo MJ, Rumbaugh KP: Pseudomonas aeruginosa biofilms perturb wound resolution and antibiotic tolerance in diabetic mice. Medical Microbiology and Immunology. 202: 131-141, 2013
Craig C, Klein M, Griswold J, Gaitonde K, McGill T, Halldorsson A: Using Cognitive Task Analysis to Identify Critical Decision in the Laparoscopic Environment. Journal of Human Factors. 54 (6): 1025-39, 2012
Simoni J, Simoni G, Moeller J, Feola M, Griswold JA, Wesson D: ATP-Adenosine-Glutathione Cross-Linked Hemoglobin as Erythropoiesis-Stimulating Agent (ESA). Journal of Artificial Organs. 36 (2): 139-150, 2012
Griswold J: Why Diabetic Wounds Do Not Heal. Texas Heart Institute Journal. 39 (6): 860-861, 2012
Schmitz B, Griswold JA: “Airway Management in Burn Patients”, Airway Management. Benumof & Hagberg 3rd edition. 2013, 44: pp 902-909
Lie DYC, Ichapurapu R, Jain S, Lopez J, Banister RE, Nguyen T, Griswold J: “A Novel Non-Contact Biosensor System for Continuous Monitoring of Vital-Signs and Handwashing Compliance”, In: Telemedicine, ISBN 978-953-307-1408-6, 2012, 9: pp 211-238
Illner H, Barber AE, Griswold JA, Hsia WG: Emerging Therapeutic Targets - Volume One, 1997, editors: R Anand, P Smith, P Warne. Ashley Publications Ltd, 1997, pp 257-261
Griswold JA: "Burns: Physical and Chemical Injuries", Conn's Current Therapy. editor: Rakel RE. W.B. Saunders Co., 1996, pp 1127-1131
Mitchell M, Griswold J: "Management of Multiple Trauma." In: General Surgery. editors: Ritchie WP, Steele G, Dean RH. Philadelphia. J.B. Lippincott, 1995,pp.919-928.
Griswold JA: "Sodium Concentrations and Burn Shock Resuscitation." Problems in General Surgery. J.B. Lippincott, 1994, 11:4, pp. 566-576
Griswold JA: "White Blood Cell Response to Burn Injury", Seminars in Nephrology. 13: 4, pp. 409-415, 1993
Lindsey AK, Allen BC, Rhodes RS, Griswold JA: "Replacement of Infected Aortic Prosthetic Grafts with Vascularized Musculofascial Flaps", Modern Vascular Surgery. editor: Chang JB. Springer-Verlang, 1992, 5: pp 153-165
Griswold JA, Molnar JA: Toxic Epidermal Necrolysis. In: Martyn JA. ed. Acute Management of the Burned Patient. Philadelphia. W.B. Saunders Co., 1990, pp.128-137.
Griswold JA, Ahnood E, Kesey JE, Elshiekh M: “Improved background pain management in burn injured and large soft tissue infection (NSTI) patients using an analgesia-only, non-drip, non-sedation protocol”. Texas Surgical Society, Midland, TX, April 7-9, 2017
Ahnood E, Kesey JE, Elshiekh M, Dissanaike S, Griswold J: “Improved background pain management in burn injured and large soft tissue infection (NSTI) patients using an analgesia-only, non-drip, non-sedation protocol.” American Burn Association, Boston, MA, March 21-24, 2017
He E., Attaluri P, Bounds K, Colmer-Hamood J, Dissanaike S, Griswold J, Myntti M, Hamood A: “Surgical irrigation fluid containing Next Science, a novel antimicrobial agent inhibits Staphylococcus aureus infection of surgical wounds.” TTUHSC Student Research Week, Lubbock, TX, March 7-10, 2017
Elmassry M, Mudaliar N, Kottapalli R, Dissanaike S, Griswold J, San Francisco M, Colmer-Hamood J, Hamood A: “The growth in blood from trauma patients produces major shifts in the Pseudomonas aeruginosa transcriptome.” TTUHSC Student Research Week, Lubbock, TX, March 7-10, 2017
Ahnood E, Griswold J, Dissanaike S, Elshiekh M, Kesey J: “The use of Methadone plus Gabapentin as a multimodal pain regimen compared with traditional pain management protocols in burn patients: a retrospective study.” Texas ACS, Austin, TX, February 23-25, 2017
Ahnood E, Griswold J, Dissanaike S, Elshiekh M, Kesey J: “The use of Methadone plus Gabapentin as a multimodal pain regimen compared with traditional pain management protocols in burn patients: a retrospective study.” Southern Region Burn Conference, Atlanta, GA, November 4-6, 2016 (oral)
Brooks S, Dissanaike S, McNabb W, Halldorsson A, Griswold J: “Use of TQIP best practice guidelines for improved care in geriatric trauma, massive transfusion and traumatic brain injury patients at a Level I Trauma Center.” Trauma Quality Improvement Program (TQIP) 2015 Annual Scientific Meeting and Training, Nashville, TN, November 15-17, 2015 (oral)
Kruczek C, Kottapalli R, Dissanaike S, Griswold J, Hamood A: “Pseudomonas aeruginosa gene expression in blood is significantly altered in burn patients.” American Burn Association, Chicago, IL, April 21-24, 2015 (oral)
Griswold JA: “The evolution of surgical training in West Texas.” Texas Surgical Society, Galveston, TX, April 10-12, 2015 (oral)
Griswold JA: “Current trends in management of major burn patients.” International College of Surgeons (ICS), Memphis, TN, June 11-14, 2014 (oral)
Abdul-Hamed S, Dissanaike S, Griswold J: “Use of indocyanine green fluorescence (ICG) as a noninvasive means to assess burn wound severity as a guide for surgery.” American Burn Association, Boston, MA, March 25-28, 2014 (Poster)
Abdul-Hamed S, Dissanaike S, Griswold J: “Use of indocyanine green fluorescence (ICG) as a noninvasive means to assess burn wound severity as a guide for surgery.” North Texas Chapter of the American College of Surgeons, Dallas, TX, February 21-22, 2014 (Poster)
Nathan JI, Kashefi NS, Halldorsson A, Griswold JA, Dissanaike S: “Can operative case time be used to evaluate resident technical efficiency?” North Texas Chapter of the American College of Surgeons, Dallas, TX, February 21-22, 2014
Abdul-Hamed S, Mikail M, Dissanaike S, Griswold J: “Snake bites in the pediatric population - is the immune Fab antivenom (Crofab) safe?" North Texas Chapter of the American College of Surgeons, Dallas, TX, February 21-22, 2014
Nathan JI, Kashefi NS, Halldorsson A, Griswold JA, Dissanaike S: “Does performing surgery after-hours significantly increase procedure time?” North Texas Chapter of the American College of Surgeons, Dallas, TX, February 21-22, 2014 (Poster)
Kesey JE, Griswold J, Phillips L, Allen C, Venable A, Dissanaike S: “Early aggressive acceleration of enteral nutrition increases ileus without perceptible benefit in severely burned patients.” American Burn Association, Palm Springs, CA, April 23-26, 2013
Cruz A, Simoni J, Griswold JA, Ray C, Nagy L: “Timing of inflicted non-accidental head trauma in infants and children based on the rate of free hemoglobin oxidation: In Vitro study.” Texas Tech University Health Sciences Center (Student Research Week), Lubbock, TX, March 4-6, 2013. (Poster)
Kesey JE, Griswold J, Phillips L, Allen C, Venable A, Dissanaike S: “Early aggressive acceleration of enteral nutrition increases ileus without perceptible benefit in severely burned patients.” Society of Critical Care Medicine, San Juan, Puerto Rico, January 19-23, 2013 (Poster)
Kesey J, Dissanaike SD, Griswold JA: “The Ups and Downs of Glycemic Control in Adult Burn Patients.” Southern Region burn Conference, Norfolk, VA, November 16-18, 2012
Vugrin M, Field DK, Edwards P, Gassett C, Shippey S, Griswold J, Dentino A: “Collaborative Efforts in Information Literacy - The Library and Clinical Clerkships: Surgery, Internal Medicine and Geriatrics.” Association of American Medical Colleges (AAMC), San Francisco, CA, November 2-7, 2012 (Poster)
Simoni J, Castillo JX, Simoni P, Moeller JF, Simoni G, Tomison MD, Campbell SJ, Griswold JA: “Effects of hemodilution with crystalloids and colloids on RBC vasodilatory signaling and oxygen affinity.” American Society for Artificial Internal Organs (ASAIO), San Francisco, CA, June 14-16, 2012
Coleman A, McGill T, Griswold J, Gard R, Holmes J: “Innovative Technique for Coverage of Neonatal Giant Abdominal Wall Defects.” American Pediatric Surgical Association, San Antonio, TX, May 20-23, 2012. (Poster)
Rumbaugh K, Dowd S, Vega D, Wolcott R, Dissanaike S, Griswold J: “Utilization of molecular sequencing methods to characterize the microflora of burn wounds during initial hospital admission.” American Burn Association, Seattle, WA, April 24-27, 2012
Melton D, Salinas K, McNabb W, McClanahan C, Griswold J, Dissanaike, S: “Kids at Risk Every Second (KARES): A Review Process of Pediatric Burns to Assess Likelihood of Intentional Injury.” American Burn Association, Seattle, WA, April 24-27, 2012. (Poster)
Atkins R, Griswold J, Haley C, Colmer-Hamood J, Hamood A: “Examining the effect of antimicrobial ointments on Pseudomonas aeruginosa biofilms using a three-dimensional wound biofilm model.” Texas Tech University Health Sciences Center (Student Research Week), Lubbock, TX, March 20-21, 2012. (Poster)
2017 Distinguished Alumni Award Honorees
Congratulations to Dr. Griswold on being selected as a TTUHSC Distinguished Alumnus for 2017! A well-deserved recognition indeed. This is the highest honor bestowed by the university, recognizing and honoring alumni who have made significant contributions to the health care profession.
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