TTUHSC School of Pharmacy
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Madala, Hanumantha Rao

Biomedical Sciences

madala
  • Graduate Student / Research Assistant

Lab Phone: 806-414-9224
E-Mail: hanumantharao.madala@ttuhsc.edu
Mail Address: 1406 S Coulter
Amarillo, TX 79106-1786

Biography

Hanumantha Rao Madala completed his Bachelor of Pharmacy degree from Rajiv Gandhi University of Health Sciences, Karnataka, India in 2010, and his Master of Science program in Industrial Pharmacy from Long Island University, Brooklyn, NY in 2014.  He joined the Graduate Program in Pharmaceutical Sciences as a PhD student in the Fall of 2014 and is presently working in the laboratory of Dr. Kalkunte S. Srivenugopal with the Department of Biomedical Sciences.

Education:

  • MS: Industrial Pharmacy, Arnold & Marie Schwartz College of Pharmacy, Long Island University, Brooklyn, NY, 2014
  • BPharm: Pharmacy, Rajiv Gandhi University of Health Sciences, Karnataka, India, 2010

Research Interests:

Anticancer drug resistance; IDH mutations in gliomas; Redox stress in cancers and exploitation for therapy.

Publications:

  • Mostofa AG, Punganuru SR, Madala HR, Al-Obaide M, Srivenugopal KS. The Process and Regulatory Components of Inflammation in Brain Oncogenesis. Biomolecules. 2017 Mar 27;7(2). pii: E34. doi: 10.3390/biom7020034.
  • Paranjpe A, Bailey NI, Konduri S, Bobustuc GC, Ali-Osman F, Yusuf MA, Punganuru SR, Madala HR, Basak D, Mostofa A, Srivenugopal KS. New insights into estrogenic regulation of O6-methylguanine DNA-methyltransferase (MGMT) in human breast cancer cells: Co-degradation of ER-α and MGMT proteins by fulvestrant or O6-benzylguanine indicates fresh avenues for therapy. J Biomed Res. 2016 Sep;30(5):393-410. doi: 10.7555/JBR.30.20160040. Epub 2016 Jun 10.
  • Punganuru SR, Mostofa AGM, Madala HR, Basak D, Srivenugopal KS. Potent anti-proliferative actions of a non-diuretic glucosamine derivative of ethacrynic acid. Bioorg Med Chem Lett. 2016 Jun 15;26(12):2829-33. doi: 10.1016/j.bmcl.2016.04.062. Epub 2016 Apr 22.
  • Punganuru SR, Madala HR, Srivenugopal KS. Colchicine-based hybrid anticancer drugs to combat tumor heterogeneity. Med Chem (Los Angeles) 2016 Mar 29, 6:3, 165-173.
  • Punganuru SR, Madala HR, Venugopal SN, Samala R, Mikelis C, Srivenugopal KS.  Design and synthesis of a C7-aryl piperlongumine derivative with potent antimicrotubule and mutant p53-reactivating properties.  Eur J Med Chem. 2016 Jan 1; 107:233-44.
  • Srivenugopal KS, Rawat A, Niture SK, Paranjpe A, Velu C, Venugopal SN, Madala HR, Basak D, Punganuru SR. Posttranslational Regulation of O(6)-Methylguanine-DNA Methyltransferase (MGMT) and New Opportunities for Treatment of Brain Cancers. Mini Rev Med Chem. 2016;16(6):455-64.

Presentations:

   Before Admission to GPPS:
  • Hanumantha Rao Madala, Somashekara Shyale. “Herbal Home Remedies and Natural Treatment”. Second IPA Students Congress, Acharya and B. M. Reddy College of Pharmacy, Bangalore, India; July 2009.
   After Admission to GPPS:
  • Podium Presentation: Hanumantha Rao Madala, Surendra Reddy Punganuru, Francis Ali-Osman, Kalkunte Srivenugopal. "Development of stable and brain-penetrating disulfiram nanoparticles, characterization and efficacy in glioma cell culture and xenograft models” Sixteenth Annual Research Days, TTUHSC School of Pharmacy, Amarillo; June 2017.
  • Podium Presentation (Mini-Symposium): Hanumantha Rao Madala, Surendra Reddy Punganuru, Kalkunte Srivenugopal. "Synthesis of a novel non-diuretic, brain-penetrating, ethacrynic acid analog and demonstration of its potent efficacy in orthotopic glioblastoma (GBM) models". Experimental Biology, Chicago, IL; April 2017.
  • Hanumantha Rao Madala, Surendra Reddy Punganuru, Kalkunte Srivenugopal. "IDH1 mutation-inspired α-ketoglutaric acid mimics for epigenetic therapy of higher grade gliomas". American Association for Cancer Research, Annual Meeting, Washington, D.C.; April 2017.
  • Hanumantha Rao Madala, Surendra Reddy Punganuru, Francis Ali-Osman, Kalkunte Srivenugopal. "Development of stable and brain-penetrating disulfiram nanoparticles, characterization and efficacy in glioma cell culture and xenograft models". American Association for Cancer Research, Annual Meeting, Washington, D.C.; April 2017.
  • Hanumantha Rao Madala, Surendra Reddy Punganuru, Kalkunte Srivenugopal. "Synthesis of a novel non-diuretic, brain-penetrating, ethacrynic acid analog and demonstration of its potent efficacy in orthotopic glioblastoma (GBM) models". Society of Toxicology, 56th Annual Meeting and ToxExpo, Baltimore, MD; March 2017.
  • Hanumantha Rao Madala, Surendra R. Punganuru and Kalkunte S. Srivenugopal. "Development of stable and brain-penetrating disulfiram nanoparticles, characterization and efficacy in malignant glioma cell culture and xenograft models". American Association of Pharmaceutical Scientists, Annual Meeting and Exposition, Denver, CO; November 2016.
  • Podium Presentation: Hanumantha Rao Madala, Surendra R. Punganuru and Kalkunte S. Srivenugopal. "Synthesis of a novel non-diuretic, brain-penetrating, ethacrynic acid analog and demonstration of its potent efficacy in orthotopic glioblastoma (GBM) models". Lone Star Regional Chapter of the Society of Toxicology, Annual Meeting, Waco, TX; October 2016.
  • Hanumantha Rao Madala, Surendra R. Punganuru and Kalkunte S. Srivenugopal. “Development of Stable and Brain-Penetrating Disulfiram Nanoparticles to Improve its Efficacy Against Malignant Gliomas.” Fifteenth Annual Research Days, TTUHSC School of Pharmacy, Amarillo, TX; June 2016.
  • Hanumantha Rao Madala, Surendra Reddy Punganuru, and Kalkunte Srivenugopal. “Potent functional inactivation of the MGMT DNA repair protein by dithiocarbamate compounds increases the efficacy of temozolomide in human glioblastoma cells.” American Association for Cancer Research Annual Meeting, New Orleans, LA; April 2016.
  • Hanumantha Rao Madala, Surendra R Punganuru, Constantinos Mikelis, Kalkunte Srivenugopal. “Design of a Rofecoxib-Combretastatin Hybrid Drug That Exerts Potent and Improved Antimicrotubule and Anti-Angiogenesis Properties Retaining Cox-2 Inhibition.” 55th Annual Meeting and ToxExpo, Society of Toxicology, New Orleans, LA; March 2016.
  • Hanumantha Rao Madala, Surendra R Punganuru, Constantinos Mikelis, Kalkunte Srivenugopal. “Design of a Rofecoxib-combretastatin Hybrid Drug That Exerts Potent and Improved Antimicrotubule and Anti-Angiogenesis Properties Retaining Cox-2 Inhibition.” Student Research Week, TTUHSC Graduate School of Biomedical Sciences, Lubbock, TX; March 2016.
  • Hanumantha Rao Madala, K.S. Srivenugopal. "Functional Inactivation MGMT DNA Repair Protein Accompanies IDH1 Mutations in Human Cancer Cells". Fourteenth Annual School of Pharmacy Research Days, TTUHSC, Amarillo, TX; June 2015.
  • Surendra Reddy Punganuru, Hanumantha Rao Madala, and Kalkunte Srivenugopal. "Hybrid cancer drugs: Synthesis of Combretastatin- Piperlongumine fused analogs with mutant p53 reactivation and antimicrotubule properties". American Association for Cancer Research, Philadelphia, PA; April 2015. [Presented by Madala.]

Seminars:

  • 02/08/2017 “Development of stable brain-penetrating disulfiram nanoparticles and elucidation of the molecular mechanisms of their cytotoxicity in glioma cell lines"
  • 10/19/2016 "Turning the Tide: Exploiting the Oncometabolite D-2 Hydroxyglutarate for Glioblastoma Therapy" [Oral Qualifying Exam, public presentation]
  • 10/21/2015 "Design of a Rofecoxib-Combretastatin Hybrid Drug that Exerts Potent and Improved Antimicrotubule and Anti-Angiogenesis Properties Retaining COX-2 Inhibition"

Awards/Scholarships:

  • Dr. Harihara Mehendale Graduate Student Best Abstract Award - Association of Scientists of Indian Origin, Society of Toxicology, Baltimore, MD, March 2017.
  • Dharm V. Singh Carcinogenesis Graduate Student Endowment Award - Second Place Abstract, Society of Toxicology, Baltimore, MD, March 2017.
  • Graduate Student Travel Support Award, Society of Toxicology, 56th Annual Meeting, Baltimore, MD, March 2017.  [received Dec'16]
  • Vector Laboratories' Photo Contest winning entry, December 2016.
  • Mary Lou Clements-Mann Endowed Scholarship, TTUHSC Graduate School of Biomedical Sciences, October 2016.
  • Travel Grant for Lone Star Regional Chapter of the Society of Toxicology, Annual Meeting, Waco, TX; October 2016

Memberships:

  • American Society for Biochemistry and Molecular Biology (ASBMB), 2017-present.
  • American Association for the Advancement of Science (AAAS), 2016-present.
  • American Society for Investigative Pathology (ASIP), 2016-present.
  • American Physiological Society (APS), 2016-present.
  • American Association of Pharmaceutical Scientists (AAPS), Pharmaco-Imaging Focus Group, Student Representative, 2016-present.
  • Society of Neuro-Oncology, 2016-present.
  • American Association of Pharmaceutical Sciences, Pharmaceutical Impurities Focus Group, Steering Committee Member, 2015-present.
  • Society of Toxicology, 2015-present.
  • American Society of Clinical Oncology (ASCO), 2015-present.
  • Graduate Student Association in Amarillo (GSAA) – International Student Representative, 2015-2016.
  • American Association for the Advancement of Science (AAAS), 2014-present.
  • American Association of Cancer Research, 2014-present.
  • Graduate Student Association in Amarillo, 2014-present.
  • American Association of Pharmaceutical Sciences, 2013-present.
  • American Association of Indian Pharmaceutical Sciences, 2012-present.
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