Pharmaceutical Sciences

madala
  • Graduate Student / Research Assistant
Lab Phone: 806-414-9224
E-Mail: hanumantharao.madala@ttuhsc.edu
Mail Address: 1406 S Coulter
Amarillo, TX 79106-1786

Biography

Hanumantha Rao Madala completed his Bachelor of Pharmacy degree from Rajiv Gandhi University of Health Sciences, Karnataka, India in 2010, and his Master of Science program in Industrial Pharmacy from Long Island University, Brooklyn, NY in 2014.  He joined the Graduate Program in Pharmaceutical Sciences as a PhD student in August of 2014 and is presently working in the laboratory of Dr. Kalkunte S. Srivenugopal with the Department of Pharmaceutical Sciences.

Education:

  • MS: Industrial Pharmacy, Arnold & Marie Schwartz College of Pharmacy, Long Island University, Brooklyn, NY, 2014
  • BPharm: Pharmacy, Rajiv Gandhi University of Health Sciences, Karnataka, India, 2010

Research Interests:

Anticancer drug resistance; IDH mutations in gliomas; Redox stress in cancers and exploitation for therapy.

Publications:

  • Punganuru SR, Madala HR, Mikelis CM, Dixit A, Arutla V, Srivenugopal KS. Conception, synthesis, and characterization of a rofecoxib-combretastatin hybrid drug with potent cyclooxygenase-2 (COX-2) inhibiting and microtubule disrupting activities in colon cancer cell culture and xenograft models. Oncotarget. 2018 May 25;9(40):26109-26129.
  • Mostofa A, Punganuru SR, Madala HR, Srivenugopal KS. S-phase Specific Downregulation of Human O6-Methylguanine DNA Methyltransferase (MGMT) and its Serendipitous Interactions with PCNA and p21cip1 Proteins in Glioma Cells. Neoplasia. 2018 Apr;20(4):305-323.
  • Madala HR, Punganuru SR, Arutla V, Misra S, Thomas TJ, Srivenugopal KS. Beyond Brooding on Oncometabolic Havoc in IDH-Mutant Gliomas and AML: Current and Future Therapeutic Strategies. Cancers (Basel). 2018 Feb 11;10(2). pii: E49.
  • Madala HR, Punganuru SR, Ali-Osman F, Zhang R, Srivenugopal KS. "Brain- and brain tumor-penetrating disulfiram nanoparticles: Sequence of cytotoxic events and efficacy in human glioma cell lines and intracranial xenografts". Oncotarget, Advance Publications. Oncotarget. 2017 Dec 15;9(3):3459-3482.
  • Mostofa AG, Punganuru SR, Madala HR, Al-Obaide M, Srivenugopal KS. The Process and Regulatory Components of Inflammation in Brain Oncogenesis. Biomolecules. 2017 Mar 27;7(2). pii: E34.
  • Paranjpe A, Bailey NI, Konduri S, Bobustuc GC, Ali-Osman F, Yusuf MA, Punganuru SR, Madala HR, Basak D, Mostofa A, Srivenugopal KS. New insights into estrogenic regulation of O6-methylguanine DNA-methyltransferase (MGMT) in human breast cancer cells: Co-degradation of ER-α and MGMT proteins by fulvestrant or O6-benzylguanine indicates fresh avenues for therapy. J Biomed Res. 2016 Sep;30(5):393-410. Epub 2016 Jun 10.
  • Punganuru SR, Mostofa AGM, Madala HR, Basak D, Srivenugopal KS. Potent anti-proliferative actions of a non-diuretic glucosamine derivative of ethacrynic acid. Bioorg Med Chem Lett. 2016 Jun 15;26(12):2829-33. Epub 2016 Apr 22.
  • Punganuru SR, Madala HR, Srivenugopal KS. Colchicine-based hybrid anticancer drugs to combat tumor heterogeneity. Med Chem (Los Angeles) 2016 Mar 29, 6:3, 165-173.
  • Punganuru SR, Madala HR, Venugopal SN, Samala R, Mikelis C, Srivenugopal KS.  Design and synthesis of a C7-aryl piperlongumine derivative with potent antimicrotubule and mutant p53-reactivating properties.  Eur J Med Chem. 2016 Jan 1; 107:233-44.
  • Srivenugopal KS, Rawat A, Niture SK, Paranjpe A, Velu C, Venugopal SN, Madala HR, Basak D, Punganuru SR. Posttranslational Regulation of O(6)-Methylguanine-DNA Methyltransferase (MGMT) and New Opportunities for Treatment of Brain Cancers. Mini Rev Med Chem. 2016;16(6):455-64.

Presentations:

   Before Admission to GPPS:

  • Hanumantha Rao Madala, Somashekara Shyale. “Herbal Home Remedies and Natural Treatment”. Second IPA Students Congress, Acharya and B. M. Reddy College of Pharmacy, Bangalore, India; July 2009.

   After Admission to GPPS:

  • Hanumantha Rao Madala, Viswanath Arutla, Surendra R. Punganuru, Kalkunte S. Srivenugopal. "Structure-Based Drug Design to Overcome Temozolomide Resistance in Glioblastoma (GBM) Through a Dual Inhibition of Mgmta and Base Excision Repair". Seventeenth Annual Research Days, TTUHSC School of Pharmacy, Amarillo, TX; June 2018.
  • Hanumantha Rao Madala, Surendra R. Punganuru, Kalkunte S. Srivenugopal. "IDH1 mutation-inspired α-ketoglutaric acid mimics for oxidative therapy of higher grade gliomas through α-ketoglutarate dehydrogenase inhibition". Experimental Biology, American Society for Investigative Pathology, San Diego, CA; April 2018.
  • PODIUM PRESENTATION: Hanumantha Rao Madala, Viswanath Arutla, Surendra R. Punganuru, Kalkunte S. Srivenugopal. "Structure-based drug design to overcome temozolomide resistance in glioblastoma (GBM) through a dual inhibition of MGMT and base excision repair". Experimental Biology, American Society for Investigative Pathology Symposium, San Diego, CA; April 2018.
  • Hanumantharao Madala, Surendra R. Punganuru, Kalkunte S. Srivenugopal. "IDH1 mutation-inspired α-ketoglutaric acid mimics for oxidative therapy of higher grade gliomas through α-ketoglutarate dehydrogenase inhibition". American Association for Cancer Research, Chicago, IL; April 2018.
  • Hanumantha Rao Madala, Surendra Reddy Punganuru, Kalkunte Srivenugopal. "IDH mutation-inspired alpha-ketoglutaric acid mimics for epigenetic therapy of higher grade gliomas". American Association of Pharmaceutical Scientists, San Diego, CA; November 2017.
  • Hanumantha Rao Madala, Surendra Reddy Punganuru, Kalkunte Srivenugopal. "Development of a novel non-diuretic brain-penetrating ethacrynic acid analog and demonstration of its potent efficacy in orthotopic glioblastoma (GBM) models". American Association of Pharmaceutical Scientists, San Diego, CA; November 2017.
  • Hanumantha Rao Madala, Surendra Reddy Punganuru, Kalkunte Srivenugopal. "Synthesis of a novel non-diuretic, brain-penetrating, ethacrynic acid analog and demonstration of its potent efficacy in orthotopic glioblastoma (GBM) models". American Society for Investigative Pathology, Pathobiology for Investigators, Students & Academicians, Pittsburgh, PA; September 2017.
  • Hanumantha Rao Madala, Surendra Reddy Punganuru, Francis Ali-Osman, Kalkunte Srivenugopal. "Development of stable and brain-penetrating disulfiram nanoparticles, characterization and efficacy in glioma cell culture and xenograft models". American Society for Investigative Pathology, Pathobiology for Investigators, Students & Academicians, Pittsburgh, PA; September 2017.
  • Hanumantha Rao Madala, Surendra Reddy Punganuru, Kalkunte Srivenugopal. "IDH1 mutation-inspired a-ketoglutaric acid mimics for epigenetic therapy of higher grade gliomas". American Society for Investigative Pathology, Pathobiology for Investigators, Students & Academicians: Genome and Environment: Implications in Development, Regeneration, Injury, Immunity, and Malignancy, Pittsburgh, PA; September 2017.
  • Hanumantha Rao Madala, Surendra Reddy Punganuru, Kalkunte Srivenugopal. "IDH mutation-inspired alpha-ketoglutaric acid mimics for epigenetic therapy of higher grade gliomas". American Association of Pharmaceutical Scientists Meeting & Expo, San Diego, CA; November 2017
  • Hanumantha Rao Madala, Surendra Reddy Punganuru, Kalkunte Srivenugopal. "Development of a novel non-diuretic brain-penetrating ethacrynic acid analog and demonstration of its potent efficacy in orthotopic glioblastoma (GBM) models". American Association of Pharmaceutical Scientists Meeting & Expo, San Diego, CA; November 2017
  • Hanumantha Rao Madala, Surendra Reddy Punganuru, Kalkunte Srivenugopal. "Synthesis of a novel non-diuretic, brain-penetrating, ethacrynic acid analog and demonstration of its potent efficacy in orthotopic glioblastoma (GBM) models". American Society for Investigative Pathology (ASIP) / Pathobiology for Investigators, Students & Academians (PISA), Pittsburgh, PA; September 2017.
  • Hanumantha Rao Madala, Surendra Reddy Punganuru, Francis Ali-Osman, Kalkunte Srivenugopal. "Development of stable and brain-penetrating disulfiram nanoparticles, characterization and efficacy in glioma cell culture and xenograft models". American Society for Investigative Pathology (ASIP) / Pathobiology for Investigators, Students & Academians (PISA), Pittsburgh, PA; September 2017.
  • Hanumantha Rao Madala, Surendra Reddy Punganuru, Kalkunte Srivenugopal. "IDH1 mutation-inspired a-ketoglutaric acid mimics for epigenetic therapy of higher grade gliomas". American Society for Investigative Pathology (ASIP) / Pathobiology for Investigators, Students & Academians (PISA): Genome and Environment: Implications in Development, Regeneration, Injury, Immunity, and Malignancy, Pittsburgh, PA; September 2017.
  • Podium Presentation: Hanumantha Rao Madala, Surendra Reddy Punganuru, Francis Ali-Osman, Kalkunte Srivenugopal. "Development of stable and brain-penetrating disulfiram nanoparticles, characterization and efficacy in glioma cell culture and xenograft models” Sixteenth Annual Research Days, TTUHSC School of Pharmacy, Amarillo; June 2017.
  • Podium Presentation (Mini-Symposium): Hanumantha Rao Madala, Surendra Reddy Punganuru, Kalkunte Srivenugopal. "Synthesis of a novel non-diuretic, brain-penetrating, ethacrynic acid analog and demonstration of its potent efficacy in orthotopic glioblastoma (GBM) models". Experimental Biology, Chicago, IL; April 2017.
  • Hanumantha Rao Madala, Surendra Reddy Punganuru, Kalkunte Srivenugopal. "IDH1 mutation-inspired α-ketoglutaric acid mimics for epigenetic therapy of higher grade gliomas". American Association for Cancer Research, Annual Meeting, Washington, D.C.; April 2017.
  • Hanumantha Rao Madala, Surendra Reddy Punganuru, Francis Ali-Osman, Kalkunte Srivenugopal. "Development of stable and brain-penetrating disulfiram nanoparticles, characterization and efficacy in glioma cell culture and xenograft models". American Association for Cancer Research, Annual Meeting, Washington, D.C.; April 2017.
  • Hanumantha Rao Madala, Surendra Reddy Punganuru, Kalkunte Srivenugopal. "Synthesis of a novel non-diuretic, brain-penetrating, ethacrynic acid analog and demonstration of its potent efficacy in orthotopic glioblastoma (GBM) models". Society of Toxicology, 56th Annual Meeting and ToxExpo, Baltimore, MD; March 2017.
  • Hanumantha Rao Madala, Surendra R. Punganuru and Kalkunte S. Srivenugopal. "Development of stable and brain-penetrating disulfiram nanoparticles, characterization and efficacy in malignant glioma cell culture and xenograft models". American Association of Pharmaceutical Scientists, Annual Meeting and Exposition, Denver, CO; November 2016.
  • Podium Presentation: Hanumantha Rao Madala, Surendra R. Punganuru and Kalkunte S. Srivenugopal. "Synthesis of a novel non-diuretic, brain-penetrating, ethacrynic acid analog and demonstration of its potent efficacy in orthotopic glioblastoma (GBM) models". Lone Star Regional Chapter of the Society of Toxicology, Annual Meeting, Waco, TX; October 2016.
  • Hanumantha Rao Madala, Surendra R. Punganuru and Kalkunte S. Srivenugopal. “Development of Stable and Brain-Penetrating Disulfiram Nanoparticles to Improve its Efficacy Against Malignant Gliomas.” Fifteenth Annual Research Days, TTUHSC School of Pharmacy, Amarillo, TX; June 2016.
  • Hanumantha Rao Madala, Surendra Reddy Punganuru, and Kalkunte Srivenugopal. “Potent functional inactivation of the MGMT DNA repair protein by dithiocarbamate compounds increases the efficacy of temozolomide in human glioblastoma cells.” American Association for Cancer Research Annual Meeting, New Orleans, LA; April 2016.
  • Hanumantha Rao Madala, Surendra R Punganuru, Constantinos Mikelis, Kalkunte Srivenugopal. “Design of a Rofecoxib-Combretastatin Hybrid Drug That Exerts Potent and Improved Antimicrotubule and Anti-Angiogenesis Properties Retaining Cox-2 Inhibition.” 55th Annual Meeting and ToxExpo, Society of Toxicology, New Orleans, LA; March 2016.
  • Hanumantha Rao Madala, Surendra R Punganuru, Constantinos Mikelis, Kalkunte Srivenugopal. “Design of a Rofecoxib-combretastatin Hybrid Drug That Exerts Potent and Improved Antimicrotubule and Anti-Angiogenesis Properties Retaining Cox-2 Inhibition.” Student Research Week, TTUHSC Graduate School of Biomedical Sciences, Lubbock, TX; March 2016.
  • Hanumantha Rao Madala, K.S. Srivenugopal. "Functional Inactivation MGMT DNA Repair Protein Accompanies IDH1 Mutations in Human Cancer Cells". Fourteenth Annual School of Pharmacy Research Days, TTUHSC, Amarillo, TX; June 2015.
  • Surendra Reddy Punganuru, Hanumantha Rao Madala, and Kalkunte Srivenugopal. "Hybrid cancer drugs: Synthesis of Combretastatin- Piperlongumine fused analogs with mutant p53 reactivation and antimicrotubule properties". American Association for Cancer Research, Philadelphia, PA; April 2015. [Presented by Madala.]

Seminars:

  • 03/02/2018 "Rational Redox-Driven Multi-Targeted Drug Discovery for Human Brain Tumors" [DOCTORAL DISSERTATION DEFENSE] (presented within Seminar course sequence)
  • 08/23/2017 "IDH1 mutation-inspired inspired α-ketoglutaric acid mimics for GBM treatment"
  • 02/08/2017 “Development of stable brain-penetrating disulfiram nanoparticles and elucidation of the molecular mechanisms of their cytotoxicity in glioma cell lines"
  • 10/19/2016 "Turning the Tide: Exploiting the Oncometabolite D-2 Hydroxyglutarate for Glioblastoma Therapy" [Oral Qualifying Exam, public presentation]
  • 10/21/2015 "Design of a Rofecoxib-Combretastatin Hybrid Drug that Exerts Potent and Improved Antimicrotubule and Anti-Angiogenesis Properties Retaining COX-2 Inhibition"

Awards/Scholarships:

  • American Association of Pharmaceutical Scientists (AAPS) Grad Student Research Award, Drug Discovery and Development Interface (DDDI), AAPS Annual Meeting & Expo, San Diego, CA; November 2017.
  • Best Abstract Award, Pathobiology for Investigators, Students & Academians (PISA), Pittsburgh, PA; Sept.2017.
  • Pathobiology for Investigators, Students & Academians (PISA) Intersociety Council for Pathology Information, Inc. (ICPI) 2017 Trainee Travel Award, American Society for Investigative Pathology (ASIP) / Pathobiology for Investigators, Students & Academians (PISA): Genome and Environment: Implications in Development, Regeneration, Injury, Immunity, and Malignancy Pittsburgh, PA, September 2017.
  • Pathobiology for Investigators, Students & Academians (PISA) American Society for Investigative Pathology (ASIP) 2017 Trainee Travel Award, American Society for Investigative Pathology (ASIP) / Pathobiology for Investigators, Students & Academians (PISA): Genome and Environment: Implications in Development, Regeneration, Injury, Immunity, and Malignancy Pittsburgh, PA, September 2017.
  • Dr. Harihara Mehendale Graduate Student Best Abstract Award - Association of Scientists of Indian Origin, Society of Toxicology, Baltimore, MD, March 2017.
  • Dharm V. Singh Carcinogenesis Graduate Student Endowment Award - Second Place Abstract, Society of Toxicology, Baltimore, MD, March 2017.
  • Graduate Student Travel Support Award, Society of Toxicology, 56th Annual Meeting, Baltimore, MD, March 2017.  [received Dec'16]
  • Vector Laboratories' Photo Contest winning entry, December 2016.
  • Mary Lou Clements-Mann Endowed Scholarship, TTUHSC Graduate School of Biomedical Sciences, October 2016.
  • Travel Grant for Lone Star Regional Chapter of the Society of Toxicology, Annual Meeting, Waco, TX; October 2016

Memberships:

  • American Society for Biochemistry and Molecular Biology (ASBMB), 2017-present.
  • American Association for the Advancement of Science (AAAS), 2016-present.
  • American Society for Investigative Pathology (ASIP), 2016-present.
  • American Physiological Society (APS), 2016-present.
  • American Association of Pharmaceutical Scientists (AAPS), Pharmaco-Imaging Focus Group, Student Representative, 2016-present.
  • Society of Neuro-Oncology, 2016-present.
  • American Association of Pharmaceutical Sciences, Pharmaceutical Impurities Focus Group, Steering Committee Member, 2015-present.
  • Society of Toxicology, 2015-present.
  • American Society of Clinical Oncology (ASCO), 2015-present.
  • Graduate Student Association in Amarillo (GSAA) – International Student Representative, 2015-2016.
  • American Association for the Advancement of Science (AAAS), 2014-present.
  • American Association of Cancer Research, 2014-present.
  • Graduate Student Association in Amarillo, 2014-present.
  • American Association of Pharmaceutical Sciences, 2013-present.
  • American Association of Indian Pharmaceutical Sciences, 2012-present.
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