TTUHSC School of Pharmacy
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Mostofa, A.G.M

Biomedical Sciences

mostofa
  • Graduate Student / Research Assistant

Lab Phone: 806-414-9229
E-Mail: agm.mostofa@ttuhsc.edu
Mail Address: 1406 S Coulter
Amarillo, TX 79106-1786

Biography

A.G.M. Mostofa received his Bachelor of Pharmacy (Honours) in 2009 From the University of Dhaka, Bangladesh. Then in 2010 he obtained a Master of Pharmacy with the same university with a specialization in clinical pharmacy and pharmacology. A.G.M. joined the Graduate Program of Pharmaceutical Sciences as a PhD student in the Fall of 2012. He is currently working in the lab of Dr. Kalkunte S. Srivenugopal with the Department of Biomedical Sciences.

Education:

  • MPharm: Pharmaceutical Sciences, University of Dhaka, Bangladesh, 2010
  • BPharm: Pharmaceutical Sciences, University of Dhaka, Bangladesh, 2009

Research Interests:

Pharmacogenetics and gene therapy.

Publications:

  • Mostofa AG, Punganuru SR, Madala HR, Al-Obaide M, Srivenugopal KS. The Process and Regulatory Components of Inflammation in Brain Oncogenesis. Biomolecules. 2017 Mar 27;7(2). pii: E34. doi: 10.3390/biom7020034.
  • Paranjpe A, Bailey NI, Konduri S, Bobustuc GC, Ali-Osman F, Yusuf MA, Punganuru SR, Madala HR, Basak D, Mostofa A, Srivenugopal KS. New insights into estrogenic regulation of O6-methylguanine DNA-methyltransferase (MGMT) in human breast cancer cells: Co-degradation of ER-α and MGMT proteins by fulvestrant or O6-benzylguanine indicates fresh avenues for therapy. J Biomed Res. 2016 Sep;30(5):393-410. doi: 10.7555/JBR.30.20160040. Epub 2016 Jun 10.
  • Punganuru SR, Mostofa AG, Madala HR, Basak D, Srivenugopal KS. Potent anti-proliferative actions of a non-diuretic glucosamine derivative of ethacrynic acid. Bioorg Med Chem Lett. 2016 Jun 15;26(12):2829-33. doi: 10.1016/j.bmcl.2016.04.062. Epub 2016 Apr 22.

Presentations:

  • Podium Presentation: AGM Mostofa, Hanumantha Rao Madala, Surendra R. Punganuru, Kalkunte S. Srivenugopal. "The S-phase checkpoint function of MGMT provides an unexpected rational route to profoundly increase the efficacy of anticancer antimetabolites in cell culture and xenograft models". Sixteenth Annual Research Days, TTUHSC School of Pharmacy, Amarillo TX; June 2017.
  • AGM Mostofa, Hanumantha Rao Madala, Surendra R. Punganuru, Kalkunte S. Srivenugopal. "The S-phase checkpoint function of MGMT provides an unexpected rational route to profoundly increase the efficacy of anticancer antimetabolites in cell culture and xenograft models". American Association for Cancer Research, Annual Meeting, Washington, D.C.; April 2017.
  • AGM Mostofa, Kalkunte S. Srivenugopal. "Interplay of human MGMT DNA repair protein with PCNA / p21cip1 and MGMT’s novel role as an S-phase checkpoint." American Association for Cancer Research, Annual Meeting, Washington, D.C.; April 2017.
  • AGM Mostofa and Kalkunte Srivenugopal. "MGMT, a Human DNA Repair Protein and Anticancer Drug Resistance Determinant Interacts with PCNA and Functions as a S-phase checkpoint". American Association of Pharmaceutical Scientists, Denver, CO; November 2016.
  • A.G.M. Mostofa, K.S. Srivenugopal. “MGMT, a Human DNA Repair Protein and Anticancer Drug Resistance Determinant Interacts with PCNA and Functions as a S-phase Checkpoint.” Fifteenth Annual Research Days, TTUHSC School of Pharmacy, Amarillo, TX; June 2016.
  • A.G.M.Mostofa and Kalkunte S. Srivenugopal. "MGMT, a Human DNA Repair Protein and Anticancer Drug Resistance Determinant Interacts With PCNA and Functions as a S-phase Checkpoint". Student Research Week, TTUHSC Graduate School of Biomedical Sciences, Lubbock, TX; March 2016.
  • A.G.M. Mostofa, Hang-Ping Yao, and Ming-Hai Wang.  "Natural Resistance to BMS-777607-Induced Polyploidy by Colorectal Cancer Cells with Retained Chemosensitivity in MET/RON Targeted Cancer Therapy".  Fourteenth Annual School of Pharmacy Research Days, TTUHSC, Amarillo, TX; June 2015.
  • A.G.M. Mostofa, Liang Feng, Hang-Ping Yao, Ruiwen Zhang, and Ming-Hai Wang. "Anti-RON Antibody-Drug Conjugates in Combination with Chemotherapeutics as a Novel Therapeutic Strategy for Targeted Therapy of Pancreatic Cancers." Thirteenth Annual School of Pharmacy Research Days, TTUHSC, Amarillo, TX; June 2014

Seminars:

  • 11/30/2016  "The S-phase checkpoint function of MGMT provides an unexpected rational route to profoundly increase the efficacy of anticancer antimetabolites in cell culture and xenograft models"
  • 04/13/2016 "MGMT, a Human DNA Repair Protein and Anticancer Drug Resistance Determinant Interacts with PCNA and Functions as an S-Phase Checkpoint"
  • 10/31/2014 "Anti-RON Antibody-Drug Conjugates: A Novel Therapeutic Strategy for Targeted Therapy of Pancreatic Cancers" [Oral Qualifying Exam, public presentation]
  • 11/20/2013 "Primary resistance to polyploidy induction as a mechanism of chemosensitivity in BMS-777607-treated colorectal cancer cells"

Awards/Scholarships:

  • TTUHSC Graduate School of Biomedical Science, President's Scholarship, to attend American Association for Cancer Research, Washington, D.C.; April 2017.
  • Graduate Student Travel Award, American Association of Bangladeshi Pharmaceutical Scientists, 10th AABPS Annual Meeting, during American Association of Pharmaceutical Scientists in Denver, CO; November 2016.
  • American Association of Pharmaceutical Scientists – Student Association, Travel Award; November 2016.
  • Outstanding Poster Presentation, Senior Graduate Student Category, Fifteenth Annual Research Week, TTUHSC School of Pharmacy, Amarillo, TX; June 2016.

Memberships:

  • Society of Toxicology; 2016-present.
  • American Association for Cancer Research; 2014-present.
  • American Association of Pharmaceutical Scientists, 2014-present.
  • Graduate Student Association at Amarillo, 2012-present.
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