Pharmaceutical Sciences

page
  • Graduate Student / Research Assistant
Lab Phone: 806-414-9258
E-Mail: shyanne.page@ttuhsc.edu
Mail Address: 1300 S Coulter
Amarillo, TX 79106-1712

Biography

Shyanne Page completed her Bachelor of Science degree in Biology from West Texas A&M University, Canyon, TX in 2014. She worked in the lab of Dr. Fakhrul Ahsan in Summer 2014 through the Amarillo Biomedical Research Internship program, and joined the Graduate Program in Pharmaceutical Sciences as a PhD student in Spring 2015. Shyanne is presently working in the laboratory of Dr. Abraham Al-Ahmad with the Department of Pharmaceutical Sciences.

Education:

  • BS: Biology, West Texas A&M University, Canyon, TX, 2014

Research Interests:

I am interested in using the potential of induced pluripotent stem cells (iPSCs) as a model to study gender-based differences in the blood-brain barrier (BBB) structure and function following hypoxic/ischemic stroke. I would also like to use this iPSC model to study epilepsy and possibly multiple sclerosis.

Publications:

  • Patel R, Page S, Al-Ahmad AJ. Isogenic blood-brain barrier models based on patient-derived stem cells display inter-individual differences in cell maturation and functionality. J Neurochem. 2017 Jul;142(1):74-88. doi: 10.1111/jnc.14040. Epub 2017 May 14.
  • Page S, Munsell A, Al-Ahmad AJ. Cerebral hypoxia/ischemia selectively disrupts tight junctions complexes in stem cell-derived human brain microvascular endothelial cells. Fluids and Barriers of the CNS. 2016 Oct 11, 13(1):16.

Presentations:

  • Shyanne Page, Mikaelan Cucciarre-Stulligross, Sarah Faress, Abraham Al-Ahmad. "Wnt of Change: Determing the Effect of the Wnt/b-Catenin Pathway on the BBB during Ischemic/Re-Oxygenation Stress". Seventeenth Annual Research Days, TTUHSC School of Pharmacy, Amarillo, TX; June 2018.
  • PODIUM PRESENTATION: Shyanne Page, Mikaelan Cuciarre-Stulligross, Sara Faress, Abraham Al-Ahmad. "Determining the effect of the WNT/b-catenin pathway on the ischemic blood-brain barrier using induced pluripotent stem cells". Experimental Biology 2018, San Diego, CA; April 2018.
  • Shyanne Page, Mikaelan Cucciare-Stuligross, Sarah Faress, Abraham Al-Ahmad. "Using induced pluripotent stem-cell-derived BMECs to determine the role that the Wnt/β-catenin pathway plays in healthy and ischemic blood-brain barriers". TTUHSC Graduate School of Biomedical Sciences 30th Annual Student Research Week, Lubbock, TX; March 2018.
  • Shyanne Page, Alli Munsell, Abraham Al-Ahmad. “Modeling the Ischemic Blood-Brain Barrier Using Patient-Derived Induced Pluripotent Stem Cells”. American Society for Investigative Pathology, Pathobiology for Investigators, Students & Academians, Pittsburgh, PA; September 2017.
  • Shyanne Page, Ronak Patel, Abraham Al-Ahmad. “Modeling the ischemic blood-brain barrier in a dish using patient-specific induced pluripotent stem cells”. Sixteenth Annual Research Days, TTUHSC School of Pharmacy, Amarillo TX; June 2017.
  • Page, Shyanne; Patel, Ronak; Munsell, Allie; Al-Ahmad, Abraham. "The ischemic blood-brain barrier in a dish: Use of patient-derived stem cells to model the response of the neurovascular unit to oxygen-glucose deprivation stress". Experimental Biology, Chicago, IL; April 2017.
  • Page, Shyanne; Patel, Ronak; Munsell, Allie; Al-Ahmad, Abraham. "The ischemic blood-brain barrier in a dish: Use of patient-derived stem cells to model the response of the neurovascular unit to oxygen-glucose deprivation stress". Student Research Week, TTUHSC Graduate School of Biomedical Sciences, Lubbock, TX; March 2017.
  • Shyanne Page, Ronak Patel and Abraham Al-Ahmad. "Building a sex-specific neurovascular unit in a dish using patient-derived human induced pluripotent stem cells". Laura W. Bush Institute for Women’s Health (LWBIWH) "Gender-Specific Medicine & Women's Health Symposium". TTUHSC, Lubbock, TX; October 2016.
  • Shyanne Page, Alli Munsell, Abraham Al-Ahmad. “Modeling the Ischemic Blood-Brain Barrier in a Dish Using Human Induced Pluripotent Stem Cells.” Fifteenth Annual Research Days, TTUHSC School of Pharmacy, Amarillo, TX; June 2016.
  • Page, Shyanne; Munsell, Alli; Al-Ahmad, Abraham. "Modeling the ischemic blood-brain barrier in a dish using human induced pluripotent stem cells." Student Research Week, TTUHSC Graduate School of Biomedical Sciences, Lubbock, TX; March 2016.
  • Page, Shyanne; Munsell, Alli; Al-Ahmad, Abraham. "Modeling the ischemic blood-brain barrier in a dish using human induced pluripotent stem cells." American Heart Association / American Stroke Association (AHA / ASA) International Stroke Conference (ISC), Los Angeles, CA; February 2016.
  • Page, Shyanne; Munsell, Alli; Patel, Ronak; Al-Ahmad, Abraham. "Adding the gender to the blood-brain barrier: modeling the human neurovascular unit using patient-derived induced pluripotent stem cells." Laura W. Bush Institute for Women's Health, Sex- and Gender-Based Medicine & Women's Health Symposium, TTUHSC Graduate School of Biomedical Sciences, Lubbock, TX; October 2015.
  • Podium Presentation: Page, Shyanne; Liles, Taylor; Patel, Ronak; Cucullo, Luca; Al-Ahmad, Abraham. "Canonical WNT pathway modulation impacts brain endothelial cell response to hypoxic stress". Cambridge Healthtech Institute’s World Preclinical Congress – Blood-Brain Barrier Conference, Boston, MA; June 2015.
  • Page, Shyanne; Liles, Taylor; Patel, Ronak; Cucullo, Luca; Al-Ahmad, Abraham. "Effect of WNT/β-catenin and hypoxia inducible factor-1 on blood-brain barrier following hypoxic injury". Student Research Week, TTUHSC Graduate School of Biomedical Sciences, Lubbock, TX; March 2015.
  • Page, Shyanne and Nilesh Gupta. "Montelukast-Filled Liposomes for the Treatment of Asthma". Amarillo Biomedical Research Internship (ABRI), TTUHSC, Amarillo, TX; August 2014.

Seminars:

  • 02/15/2017  "Determining the influence of gender on blood-brain barrier function during cerebral ischemia using human-induced pluripotent stem cells"
  • 02/10/2016 "Modeling the ischemic blood-brain barrier in a dish using human induced pluripotent stem cells"

Awards/Scholarships

  • Lawrence and Marion Muller 2017 Memorial Trainee Travel Award for Excellence in Neurodegenerative Disease Research, American Society for Investigative Pathology (ASIP), Pathobiology for Investigators, Students & Academians (PISA) Pathobiology for Investigators, Students & Academians, Pittsburgh, PA; September 2017.
  • Meritorious Acknowledgement, Basic Science Award, Laura W. Bush Institute for Women’s Health (LWBIWH)/TTUHSC, 5th Annual Gender-Specific Medicine & Women's Health Symposium, Lubbock, TX; October 2016.

Memberships:

  • American Society of Investigative Pathology (ASIP), 2017-present.
  • Graduate Student Association at Amarillo – Vice-President, 2016-2017.
  • Graduate Student Association at Amarillo, 2015-present
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