Jannette M. Dufour, Ph.D.
| Assistant Professor | jannette.dufour@ttuhsc.edu (806)743-2616 |
Research Interests
Current research is focused on the use of immunoprotective Sertoli cells in transplantation. Specifically, we are testing the feasibility of using immune-privileged Sertoli cells as a vehicle to deliver insulin for treatment of diabetes in rodents. The second major focus of our research is to examine the mechanism of Sertoli cell immune-privilege in order to improve outcomes of transplantation.
Biography
| 2005 - Present | Assistant Professor, Cell Biology and Biochemistry Texas Tech University Health Science Center |
| 1999 - 2005 | Post Doctoral Fellow, Islet Transplantation Laboratory Surgical Medical Research Institute, University of Alberta |
| 1994 - 1999 | Washington State University Ph. D. in Genetics and Cell Biology |
| 1992 - 1994 | Central Washington University B.S. in Chemistry, B.A. in Biology |
Recent Publications
- Dufour JM, Rajotte RV, Seeberger K, Kin T, Korbutt GS. 2003 Long-term survival of neonatal porcine Sertoli cells in non- immunosuppressed rats. Xenotransplantation 10:577-586.
- Dufour JM, Hemendinger R, Halberstadt CR, Gores P, Emerich DF, Korbutt GS, Rajotte RV. 2004 Genetically engineered Sertoli cells are able to survive allogeneic transplantation. Gene Therapy 11:694-700.
- Kin T, Korbutt GS, Kobayashi T, Dufour JM, Rajotte. 2005 Reversal of diabetes in pancreatectomized pigs after transplantation of neonatal porcine islets. Diabetes 54:1032-1039.
- Dufour JM, Hamilton M, Rajotte RV, Korbutt GS. 2005 Neonatal porcine Sertoli cells inhibit human natural antibody mediated lysis. Biology of Reproduction 72:1224-1231.
- Dufour JM, Rajotte RV, Zimmerman M, Rezania A, Kin T, Dixon DE, Korbutt GS. 2005 Development of an ectopic site for islet transplantation using biodegradable scaffolds. Tissue Engineering 9/10:1323-1331.
- Lord SJ, Sipione S, Motyka B, Ewen C, Shostak I, Rayat GR, Dufour JM, Korbutt GS, Rajotte RV, Bleackley RC. 2006 Identification of a novel human granzyme B inhibitor secreted by cultured Sertoli cells. Journal of Immunology 177:5051-5058.
- Dufour JM, Lord SJ, Kin T, Rayat GR, Dixon DE, Bleackley RC, Korbutt GS, Rajotte RV. 2008 Comparison of successful and unsuccessful islet/Sertoli cell co-transplant grafts in streptozotocin induced diabetic mice. Cell Transplantation 16:1029-1038.
- Dufour JM, Dass B, Halley K, Korbutt GS, Dixon DE, Rajotte RV. 2008 Sertoli cell line lacks the immunoprotective properties associated with primary Sertoli cells. Cell Transplantation 17:525-534. Cover photo
- Mital P, Kaur G, Dufour JM. 2010 Immunoprotective Sertoli cells: Making allogeneic and xenogeneic transplantation feasible. Reproduction 139:495-504.
- Halley KR, Dyson EL, Kaur G, Mital P, Uong P, Dass B, Dufour JM. 2010 Delivery of a therapeutic protein by immune privileged Sertoli cells. Cell Transplantation 19:1645-1657.
- Mital P, Hinton BT, Dufour JM. 2011 The blood-testis and blood-epididymal barriers are more than just their tight junctions. Biology of Reproduction 84:851–858.