Barry Maurer, M.D. Ph.D.
Research Interests
His research focuses on retinoids, “vitamin A derivatives” as tumor-selective differentiation or cytotoxic agents, mechanisms of drug resistance and drugs to modulate resistance in childhood and adult cancers, development of novel preclinical testing models for childhood and adult cancer drug development, and clinical trials testing novel therapeutic approaches for cancer.
History & Education
Degrees
| 1990 |
Wayne State University |
M D |
|
| 1990 |
California Institute of Technology |
Ph D |
|
Residencies
| 1991-1993 |
LAC/USC Medical Center |
Fellowships
| 199 -1997 |
Clinical Fellow |
Fred Hutchinson Cancer Research Center |
| 1997-2000 |
Research Fellow |
Childrens Hospital Los Angeles Research Institute |
Board Certification
| 2000 |
American Board of Pediatrics |
General Pediatrics |
|
| 2005 |
American Board of Pediatrics |
Hematology/Oncology |
|
Awards
| 1974 |
National Merit Scholarship |
| 1980 |
NIH NRSA Predoctoral Traineeship |
| 1987 |
Summer Science Research Program for Medical Students March of Dimes Birth Defects Foundation |
| 1990 |
M.D. (Distinction in Biomedical Research) |
| 2004 |
Eurand Award for Novel Approaches in Oral Drug Delivery, Controlled Release Society, 31st Annual Meeting 2004, for novel LXS oral fenretinide formulation. |
Memberships & Affiliations
- American Association of Cancer Research
- International Society of Paediatric Oncology
- Children's Oncology Group
Publications
- Maurer, B.J., Melton, L., Billups, C., Cabot, M.C., and Reynolds, C.P. "Synergistic Cytotoxicity in Solid Tumor Cell Lines Between N-(4-hydroxyphenyl)retinamide and Modulators of Ceramide Metabolism." J Natl Cancer Inst 92:1897-1909 (2000).
- Wang, H., Maurer, B.J., Reynolds, C.P. and Cabot, M.C. "N-(4-Hydroxyphenyl)retinamide Elevates Ceramide in Neuroblastoma Cell Lines by Coordinate Activation of Serine Palmitoyltransferase and Ceramide Synthase." Cancer Res 61:5102-5105 (2001).
- O'Donnell, P.H., Guo, W-X., Reynolds, C.P., Maurer, B.J. "N-(4-hydroxyphenyl)- retinamide Increases Ceramide and Is Cytotoxic to Acute Lymphoblastic Leukemia Cell Lines, but Not to Non-Malignant Lymphocytes." Leukemia 16:902-10 (2002).
- Vratilova, J., Frgala, T., Maurer, B.J. and Reynolds, C.P. "Liquid chromatography method for quantifying N-(4-hydroxyphenyl)retinamide and N-(4-methoxyphenyl)retinamide in tissues." Journal of Chromatography 808:125-30 (2004).
- Batra, S., Reynolds, C.P., and Maurer, B.J., "Fenretinide Cytotoxicity for Ewing's Sarcoma (ES) and Primitive Neuroectodermal Tumor (PNET) Cell Lines is Decreased by Hypoxia and Synergistically Enhanced by Ceramide Modulators." Cancer Res 64:5415-5424 (2004).
