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Matthew B. Grisham, PhD
Professor and Chair
Vernon and Elizabeth Haggerton Chair in Gastroenterology
Department of Immunology and Molecular Microbiology
Matthew B. Grisham, PhD
Matthew B. Grisham is Professor and Chair of the Department of Immunology and Molecular
Microbiology and the Vernon and Elizabeth Chair in Gastroenterology at Texas Tech
University Health Sciences Center in Lubbock, Texas. Dr. Grisham graduated from the
University of South Florida in Tampa, Florida with a B.A. degree (with honors) in
Biology in 1975. He then enrolled in the PhD program at Texas Tech University Health
Sciences Center where he received his PhD. in Biochemistry from the Department of
Biochemistry in 1982. Dr. Grisham then moved to Memphis, Tennessee where he was awarded
a Post Doctoral Fellowship in Immunology and Inflammation at St. Jude Children’s Research
Hospital. In 1984, Dr. Grisham was recruited to the University of South Alabama College
of Medicine where he assumed the position of Assistant Professor in the Department
of Biochemistry. Three years later, he was recruited to the Department of Molecular
and Cellular Physiology at LSU Health Sciences Center in Shreveport, Louisiana where
he rose through the ranks achieving the position of Boyd Professor and Associate Director
of the Center of Excellence for Arthritis and Rheumatology. In 2012, Dr. Grisham was
recruited to Texas Tech University Health Sciences Center where he assumed the position
of Professor and Chair of the Department of Immunology and Molecular Microbiology.
Dr. Grisham has received several honors and awards including the Distinguished Alumni
Award from Texas Tech University Health Sciences Center, the Intestinal Diseases Research
Award from the University of Calgary Health Sciences Center in Calgary, Canada, the
William A. Pryor Distinguished Lectureship Award from Louisiana State University (LSU)
in Baton Rouge and the Boyd Professorship awarded by the LSU System Office. Dr. Grisham
has held numerous national and international leadership positions over the past two
decades including his service as the President of the Society for Free Radical Biology and Medicine, President of the Gulf Coast Physiological Society, Councilor for the Immunology, Microbiology
and Inflammatory Bowel Disease section of the American Gastroenterological Association
and Chair of the Gastrointestinal and Liver Section of the American Physiological Society.
He has served or is currently serving as an Associate Editor for the journals Free Radical Biology and Medicine; Inflammatory Bowel Diseases, American Journal of
Physiology and Journal of Clinical Biochemistry and Nutrition. In addition, he has served or is currently serving on the editorial boards of the
Journal of Immunology, Inflammatory Bowel Diseases and the American Journal of Physiology. Dr. Grisham continues to serve as an active member of the Grants Review Committee
for the Crohn’s and Colitis Foundation of America and has served or is currently serving
as a member on several different Study Sections/Grants Review Committees for the National
Institutes of Health (NIH). Dr. Grisham’s research focuses on the pathogenesis and
regulation of chronic intestinal inflammation. His research has been continuously
funded for the past 25 years by the NIH. He has published more than 290 peer-reviewed
journal articles, 76 book chapters, edited two books and written one book all related
to the pathogenesis and regulation of acute and chronic inflammation.
The intestinal mucosa encounters more antigens and potential pathogens than any other
tissue in the body. Consequently, the small and large intestine represent the largest
and most complex components of the immune system. Fortunately, the intestine and its
associated lymphoid tissue have evolved efficient mechanisms to distinguish between
potentially pathogenic microorganisms and harmless dietary antigens and commensal
(nonpathogenic) bacteria. The inability to properly regulate these different immune
responses is thought to lead to chronic inflammatory disorders such as the inflammatory
bowel diseases (IBD; Crohn's disease; ulcerative colitis). Patients with IBD experience
rectal bleeding, severe diarrhea, abdominal pain, fever and weight loss that coincides
with the infiltration of large numbers of potentially injurious leukocytes into the
intestinal tissue. My laboratory is interested in defining the molecular, cellular
and immunological mechanisms responsible for the induction, perpetuation and regulation
of chronic intestinal inflammation. Our research focuses on three major aspects of
intestinal immunity related to the pathogenesis and treatment of IBD including: a)
T cell trafficking to the gut-associated lymphoid tissue and intestine; b) Characterization
of the intestinal microbiota prior to and following the onset of chronic gut inflammation;
and c) Cell-based therapeutic strategies to suppress or reverse chronic inflammation.
It is our hope that data obtained from these investigations will reveal novel therapeutic
strategies that may be used to treat patients with these devastating diseases.
- Multiplex protein arrays.
- Florescence-activated cell sorting (FACS) and analysis.
- Cell and Tissue Culture.
- Genetically-engineered and immune-manipulated mouse models of chronic disease.
- Microbiome Characterization
For a complete list of publications by Matthew B. Grisham in PubMed click here