Immunology and Molecular Microbiology
Image Analysis Core Facility
The Department of Immunology and Molecular Microbiology occupies more than 15,000
sq. ft. of laboratory space within Texas Tech University Health Sciences Center (TTUHSC)
that contains state-of-the-art molecular, cellular and immunological instrumentation.
In addition to departmental equipment, faculty and students have full access to the
new state-of-the-art Image Analysis and Molecular Core Facility.
TTUHSC is one of only three institutions in Texas to have this type of capability.
The new 1,200-square-foot facility houses more than $2 million of laboratory equipment.
The most powerful instrument in the Core Facility is a Nikon TiE confocal microscope
equipped with an option known as N-STORM (Nikon Stochastic Optical Resolution Microscopy).
This ultra-high resolution microscope enlarges images 6,000 to 10,000 times larger
than the human eye can see. The microscope utilizes fluorescent probes to mark molecules
in the cells. It scans the images 50,000 times or more, and within an hour can produce
intricate images of the smallest structures within the samples. The images can also
be combined to produce a 3-D model on a computer screen, so that the model can be
moved to undergo more intricate analysis. In addition, this core houses a Zeiss LSM510/Meta
confocal microscope, a Metafluor Imaging System and a variety of multimodality microscopes
for imaging un-stained or fluorescently stained cells and thin sections. The Zeiss
AxioCam CCD camera can be easily attached to the different microscopes for capturing
Molecular Biology Core Facility
This is the newest core facility to open at TTUHSC. This 1,200-square foot facility
houses the very latest molecular and cellular analytical equipment including an Amnis
ImageStream cell analyzer, an Accuri C6 flow cytomer and a FACSJazz cell sorter. In
addition, the Molecular Biology Core Facility houses the GE Typhoon and phosphorescence/luminescence
analyzer and a Biolector as well as an Agilent Bioanalyzer and C1-Cell Autopreparation
system. Fluidigm Autoprep and Access Array systems are also housed in this core facility
as well as different PCR instrumentation and automated cell counters.
In addition to the core facilities, faculty and students have access to a second Flow
Cytometry laboratory that is operated by the Cancer Center in the School of Medicine.
This state-of-the-art facility has a BD LSR II flow cytometer and a FACSAria cell
sorter. The LSR II is capable of analyzing 16 simultaneous colors. TTUHSC also maintains
a modern and well-equipped animal care facility that occupies 31,000 sq. ft. of space
within the School of Medicine. This facility houses procedural space, conventional
housing for rodents, barrier housing for immuno-deficient and germ-free rodents, and
housing for non-rodent species. A new and free-standing medical library is located
next to the Health Sciences Center building and is readily available to all of our
students, faculty and staff.
Other Core Facilities and Centers
TTUHSC Centers & Institutes
School of Medicine Cancer Center
Tropical Medicine and Infectious Diseases
F. Marie Hall SimLife Center