Immunology and Molecular Microbiology
Image Analysis Core Facility
The Department of Immunology and Molecular Microbiology occupies more than 15,000 sq. ft. of laboratory space within Texas Tech University Health Sciences Center (TTUHSC) that contains state-of-the-art molecular, cellular and immunological instrumentation. In addition to departmental equipment, faculty and students have full access to the new state-of-the-art Image Analysis and Molecular Core Facility.
TTUHSC is one of only three institutions in Texas to have this type of capability. The new 1,200-square-foot facility houses more than $2 million of laboratory equipment. The most powerful instrument in the Core Facility is a Nikon TiE confocal microscope equipped with an option known as N-STORM (Nikon Stochastic Optical Resolution Microscopy). This ultra-high resolution microscope enlarges images 6,000 to 10,000 times larger than the human eye can see. The microscope utilizes fluorescent probes to mark molecules in the cells. It scans the images 50,000 times or more, and within an hour can produce intricate images of the smallest structures within the samples. The images can also be combined to produce a 3-D model on a computer screen, so that the model can be moved to undergo more intricate analysis. In addition, this core houses a Zeiss LSM510/Meta confocal microscope, a Metafluor Imaging System and a variety of multimodality microscopes for imaging un-stained or fluorescently stained cells and thin sections. The Zeiss AxioCam CCD camera can be easily attached to the different microscopes for capturing images.
Molecular Biology Core Facility
This is the newest core facility to open at TTUHSC. This 1,200-square foot facility houses the very latest molecular and cellular analytical equipment including an Amnis ImageStream cell analyzer, an Accuri C6 flow cytomer and a FACSJazz cell sorter. In addition, the Molecular Biology Core Facility houses the GE Typhoon and phosphorescence/luminescence analyzer and a Biolector as well as an Agilent Bioanalyzer and C1-Cell Autopreparation system. Fluidigm Autoprep and Access Array systems are also housed in this core facility as well as different PCR instrumentation and automated cell counters.
In addition to the core facilities, faculty and students have access to a second Flow Cytometry laboratory that is operated by the Cancer Center in the School of Medicine. This state-of-the-art facility has a BD LSR II flow cytometer and a FACSAria cell sorter. The LSR II is capable of analyzing 16 simultaneous colors. TTUHSC also maintains a modern and well-equipped animal care facility that occupies 31,000 sq. ft. of space within the School of Medicine. This facility houses procedural space, conventional housing for rodents, barrier housing for immuno-deficient and germ-free rodents, and housing for non-rodent species. A new and free-standing medical library is located next to the Health Sciences Center building and is readily available to all of our students, faculty and staff.
Other Core Facilities and Centers
TTUHSC Centers & Institutes
School of Medicine Cancer Center
Tropical Medicine and Infectious Diseases
F. Marie Hall SimLife Center