TTUHSC School of Medicine
Internal Medicine

Internal Medicine

Faculty Listing » Oncology


Maurizio Chiriva

Maurizio Chiriva, PhD

Assistant Professor
 

Office: 806-743-3155
Email: maurizio.chiriva@ttuhsc.edu

Patient Appointments:
No information available
Clinic Location:
No information available

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Education:

  • Fellowship: No information available
  • Residency: No information available
  • Medical School: No information available
  • Undergraduate School: University of Nottingham School of Medicine, Nottingham, United Kingdom

Publications:

  • Galectin-3C Inhibits Tumor Growth and Increases the Anticancer Activity of Bortezomib in a Murine Model of Human Multiple Myeloma.Mirandola L, Yu Y, Chui K, Jenkins MR, Cobos E, John CM, Chiriva-Internati M.PLoS One. 2011;6(7):e21811. Epub 2011 Jul 13.
  • Cancer testis antigen, ropporin, is a potential target for multiple myeloma immunotherapy.Chiriva-Internati M, Mirandola L, Yu Y, Jenkins MR, Gornati R, Bernardini G, Gioia M, Chiaramonte R, Cannon MJ, Kast WM, Cobos E.J Immunother. 2011 Jul-Aug;34(6):490-9.
  • Notch-ing from T-cell to B-cell lymphoid malignancies.Mirandola L, Comi P, Cobos E, Kast WM, Chiriva-Internati M, Chiaramonte R.Cancer Lett. 2011 Sep 1;308(1):1-13.
  • Genistein inhibited proliferation and induced apoptosis in acute lymphoblastic leukemia, lymphoma and multiple myeloma cells in vitro.Li W, Frame LT, Hoo KA, Li Y, D'Cunha N, Cobos E. Leuk Lymphoma. 2011 Jul 13. [Epub ahead of print]
  • CRM1-dependent p53 nuclear accumulation in lung lesions of a bitransgenic mouse lung tumor model.Chen L, Moore JE, Samathanam C, Shao C, Cobos E, Miller MS, Gao W. Oncol Rep. 2011 Jul;26(1):223-8. doi: 10.3892/or.2011.1279. Epub 2011 Apr 21.
  • Sperm protein 17: clinical relevance of a cancer/testis antigen, from contraception to cancer immunotherapy, and beyond.Chiriva-Internati M.Int Rev Immunol. 2011 Apr-Jun;30(2-3):138-49.
  • Cancer testis antigens: novel biomarkers and targetable proteins for ovarian cancer.Mirandola L, J Cannon M, Cobos E, Bernardini G, Jenkins MR, Kast WM, Chiriva-Internati M.Int Rev Immunol. 2011 Apr-Jun;30(2-3):127-37.
  • Prospects and challenges for immunotherapy of ovarian cancer--what can we learn from the tumor microenvironment?Chiriva-Internati M, Cobos E, Cannon MJ.Int Rev Immunol. 2011 Apr-Jun;30(2-3):67-70.
  • Understanding the cross-talk between ovarian tumors and immune cells: mechanisms for effective immunotherapies.Chiriva-Internati M, Mirandola L, Kast WM, Jenkins MR, Cobos E, Cannon MJ.Int Rev Immunol. 2011 Apr-Jun;30(2-3):71-86.
  • Identification of AKAP-4 as a new cancer/testis antigen for detection and immunotherapy of prostate cancer.Chiriva-Internati M, Yu Y, Mirandola L, D'Cunha N, Hardwicke F, Cannon MJ, Cobos E, Kast WM.Prostate. 2011 Apr 25. doi: 10.1002/pros.21400. [Epub ahead of print]
  • Dendritic cell vaccination against ovarian cancer--tipping the Treg/TH17 balance to therapeutic advantage? Cannon MJ, Goyne H, Stone PJ, Chiriva-Internati M. Expert Opin Biol Ther. 2011 Apr;11(4):441-5. Epub 2011 Jan 28. Review.
  • Nanotechnology and human health: risks and benefits. Cattaneo AG, Gornati R, Sabbioni E, Chiriva-Internati M, Cobos E, Jenkins MR, Bernardini G. J Appl Toxicol. 2010 Nov;30(8):730-44. doi: 10.1002/jat.1609. Review.
  • Ukrain affects pancreas cancer cell phenotype in vitro by targeting MMP-9 and intra-/extracellular SPARC expression. Funel N, Costa F, Pettinari L, Taddeo A, Sala A, Chiriva-Internati M, Cobos E, Colombo G, Milzani A, Campani D, Dalle-Donne I, Gagliano N. Pancreatology. 2010;10(5):545-52. Epub 2010 Oct 23.
  • Cancer testis antigen vaccination affords long-term protection in a murine model of ovarian cancer. Chiriva-Internati M, Yu Y, Mirandola L, Jenkins MR, Chapman C, Cannon M, Cobos E, Kast WM. PLoS One. 2010 May 12;5(5):e10471.
  • Glioma-astrocyte interaction modifies the astrocyte phenotype in a co-culture experimental model. Gagliano N, Costa F, Cossetti C, Pettinari L, Bassi R, Chiriva-Internati M, Cobos E, Gioia M, Pluchino S. Oncol Rep. 2009 Dec;22(6):1349-56. PMID: 20809446 [PubMed - in process]
  • Sperm protein 17 is expressed in the sperm fibrous sheath. Chiriva-Internati M, Gagliano N, Donetti E, Costa F, Grizzi F, Franceschini B, Albani E, Levi-Setti PE, Gioia M, Jenkins M, Cobos E, Kast WM. J Transl Med. 2009 Jul 15;7:61.
  • Expression profiling of genes involved in collagen turnover in tendons from cerebral palsy patients. Gagliano N, Pelillo F, Chiriva-Internati M, Picciolini O, Costa F, Schutt RC Jr, Gioia M, Portinaro N. Connect Tissue Res. 2009;50(3):203-8.
  • rAAV/Her-2/neu loading of dendritic cells for a potent cellular-mediated MHC class I restricted immune response against ovarian cancer. Yu Y, Pilgrim P, Zhou W, Gagliano N, Frezza EE, Jenkins M, Weidanz JA, Lustgarten J, Cannon M, Bumm K, Cobos E, Kast WM, Chiriva-Internati M. Viral Immunol. 2008 Dec;21(4):435-42.
  • A new immunomodulatory therapy for severe sepsis: Ulinastatin Plus Thymosin {alpha} 1. Li Yumin, Chen Hao, Li Xun, Zhou Wence, He Minyan, Chiriva-Internati M, Wachtel MS, Frezza EE. J Intensive Care Med. 2009 Jan-Feb;24(1):47-53. Epub 2008 Nov 25.
  • Transduction of PACAP38 protects primary cortical neurons from neurotoxic injury. Sanchez A, Chiriva-Internati M, Grammas P. Neurosci Lett. 2008 Dec 19;448(1):52-5. Epub 2008 Oct 14.
  • Protective CD8+ T-cell responses to cytomegalovirus driven by rAAV/GFP/IE1 loading of dendritic cells. Yu Y, Pilgrim P, Yan J, Zhou W, Jenkins M, Gagliano N, Bumm K, Cannon M, Milzani A, Dalle-Donne I, Kast WM, Cobos E, Chiriva-Internati M. J Transl Med. 2008 Oct 5;6:56.
  • Biological treatment for liver tumor and new potential biomarkers.Chiriva-Internati M, Grizzi F, Wachtel MS, Jenkins M, Ferrari R, Cobos E, Frezza EE.Dig Dis Sci. 2008 Mar;53(3):836-43. Epub 2007 Aug 22. Review.
  • Effect of a topical treatment in organotypic culture of human breast skin after exposure to gamma-rays. Gagliano N, Bedoni M, Mantovani G, Chiriva-Internati M, Castelli D, Torri C, Donetti E. Eur J Histochem. 2007 Oct-Dec;51(4):283-90.
  • AKAP-4: a novel cancer testis antigen for multiple myeloma. Chiriva-Internati M, Ferrari R, Yu Y, Hamrick C, Gagliano N, Grizzi F, Frezza E, Jenkins MR, Hardwick F, D'Cunha N, Kast WM, Cobos E. Br J Haematol. 2008 Feb;140(4):465-8. No abstract available. PMID: 18217892 [PubMed - indexed for MEDLINE]
  • A paradigm shift in therapeutic vaccination of cancer patients: the need to apply therapeutic vaccination strategies in the preventive setting. Gray A, Raff AB, Chiriva-Internati M, Chen SY, Kast WM. Immunol Rev. 2008 Apr;222:316-27. Review. PMID: 18364011 [PubMed - indexed for MEDLINE]
  • The pituitary tumor transforming gene 1 (PTTG-1): an immunological target for multiple myeloma. Chiriva-Internati M, Ferrari R, Prabhakar M, Yu Y, Baggoni L, Moreno J, Gagliano N, Portinaro N, Jenkins MR, Frezza EE, Hardwicke F, D'Cunha N, Kast W, Cobos E. J Transl Med. 2008 Apr 2;6:15.
  • Silibinin restores paclitaxel sensitivity to paclitaxel-resistant human ovarian carcinoma cells. Zhou L, Liu P, Chen B, Wang Y, Wang X, Chiriva Internati M, Wachtel MS, Frezza EE. Anticancer Res. 2008 Mar-Apr;28(2A):1119-27.
  • Sperm fibrous sheath proteins: a potential new class of target antigens for use in human therapeutic cancer vaccines. Chiriva-Internati M, Cobos E, Da Silva DM, Kast WM. Cancer Immun. 2008 Apr 24;8:8. Review.
  • Analysis of the results of sleeve gastrectomy for morbid obesity and the role of ghrelin. Frezza EE, Chiriva-Internati M, Wachtel MS. Surg Today. 2008;38(6):481-3. Epub 2008 May 31. Review.
  • A therapeutic dose of FK506 does not affect collagen turnover pathways in healthy human gingival fibroblasts. Gagliano N, Moscheni C, Tartaglia GM, Selleri S, Chiriva-Internati M, Cobos E, Torri C, Costa F, Pettinari L, Gioia M. Transplant Proc. 2008 Jun;40(5):1419-24.
  • Sperm protein 17 is a suitable target for adoptive T-cell-based immunotherapy in human ovarian cancer. Chiriva-Internati M, Weidanz JA, Yu Y, Frezza EE, Jenkins MR, Kennedy RC, Cobos E, Kast WM. J Immunother. 2008 Oct;31(8):693-703.
  • Usefulness of cancer-testis antigens as biomarkers for the diagnosis and treatment of hepatocellular carcinoma. Grizzi F, Franceschini B, Hamrick C, Frezza EE, Cobos E, Chiriva-Internati M. J Transl Med. 2007 Jan 23;5:3. Review.
  • The multiple faces of glucagon-like peptide-1--obesity, appetite, and stress: what is next? A review. Frezza EE, Wachtel MS, Chiriva-Internati M. Dig Dis Sci. 2007 Mar;52(3):643-9. Review.
  • Human binucleate hepatocytes: are they a defence during chronic liver diseases? Grizzi F, Chiriva-Internati M. Med Hypotheses. 2007;69(2):258-61. Epub 2007 Feb 20.
  • A NOD/SCID tumor model for human ovarian cancer that allows tracking of tumor progression through the biomarker Sp17. Chiriva-Internati M, Grizzi F, Weidanz JA, Ferrari R, Yuefei Y, Velez B, Shearer MH, Lowe DB, Frezza EE, Cobos E, Kast WM, Kennedy RC. J Immunol Methods. 2007 Apr 10;321(1-2):86-93. Epub 2007 Feb 9.
  • Increased age, male gender, and cirrhosis, but not steatosis or a positive viral serology, negatively impact the life expectancy of patients who undergo liver biopsy. Wachtel MS, Zhang Y, Kaye KE, Chiriva-Internati M, Frezza EE. Dig Dis Sci. 2007 Sep;52(9):2276-81. Epub 2007 Apr 4.
  • Calcitonin receptor-stimulated migration of prostate cancer cells is mediated byurokinase receptor-integrin signaling. Thomas S, Chiriva-Internati M, Shah GV. Clin Exp Metastasis. 2007;24(5):363-77. Epub 2007 May 9.
  • Geometry of human vascular system: is it an obstacle for quantifying antiangiogenic therapies? Grizzi F, Colombo P, Taverna G, Chiriva-Internati M, Cobos E, Graziotti P, Muzzio PC, Dioguardi N. Appl Immunohistochem Mol Morphol. 2007 Jun;15(2):134-9. Review.
  • Advances in immunotherapy of multiple myeloma: from the discovery of tumor-associated antigens to clinical trials. Chiriva-Internati M, Cobos E, Kast WM. Int Rev Immunol. 2007 May-Aug;26(3-4):197-222. Review.
  • The role of radiofrequency ablation in multiple liver metastases to debulk the tumor: a pilot study before alternative therapies. Frezza EE, Wachtel MS, Barragan B, Chiriva-Internati M, Cobos E. J Laparoendosc Adv Surg Tech A. 2007 Jun;17(3):282-4.

Presentations:

  • Southern Regional Meetings, “Ropporin is a novel cancer testis antigen for multiple myeloma.” New Orleans, LA. 2007.
  • PTTG-1: An Immunological Target for Multiple Myeloma. Southern Regional Meetings, New Orleans, LA. 2007.
  • AKAP-associated sperm protein over-expression in ovarian cancer. Southern Regional Meetings, New Orleans, LA. 2007.
  • Cancer Testis Antigen (CTA): is AKAP-4 a novel CTA for Multiple Myeloma? Southern Regional Meetings, New Orleans, LA. 2007.
  • Usefulness of cancer-testis antigens as biomarkers for the diagnosis and treatment of hepatocellular carcinoma. American College of Surgeons 93rd Annual Clinical Congress, New Orleans, LA. October 7-11, 2007.
  • Increased age, male gender and cirrhosis, but not steatosis or a positive viral serology, negatively impact the life expectancy of patients who undergo liver biopsy. American College of Surgeons 93rd Annual Clinical Congress, New Orleans, LA. October 7-11, 2007.
  • Pancreas cancer survival can be precisely predicted by grade and stage. American College of Surgeons 93rd Annual Clinical Congress, New Orleans, LA. Ernest N. October 7-11, 2007.
  • Immunological Treatment of Liver Tumors. American College of Surgeons 93rd Annual Clinical Congress, New Orleans, LA. October 7-11, 2007.
  • Sp17: a novel biomarker for early screening of prostate cancer patients. TXSAN, Austin, TX, 2007.
  • Ropporin is a novel cancer testis antigen for multiple myeloma. American Association of Immunology’s 94th Anniversary Annual Meeting, May 16-22, 2007.
  • Characterization of collagen turnover pathways in human aging gingival fibroblasts. Southern Regional Meetings and the Southern Society for Clinical Investigation (SSCI) annual meeting, New Orleans, 21-23 febbraio 2008. J. Invest. Med. 56: 380-381, 2008.
  • Analysis of collagen turnover in healthy human gingival fibroblasts treated with different doses of tacrolimus. Southern Regional Meetings and the Southern Society for Clinical Investigation (SSCI) annual meeting, New Orleans, 21-23 February 2008.J. Invest. Med. 56: 357-358, 2008.
  • AKAP-4 as biomarker for prostate cancer.Southern Regional Meetings and the Southern Society for Clinical Investigation (SSCI) annual meeting, New Orleans, 21-23 febbraio 2008. J. Invest. Med. 56: 394, 2008.
  • Sperm protein 17 is expressed in primary and metastatic breast cancer. Southern Regional Meetings and the Southern Society for Clinical Investigation (SSCI) annual meeting, New Orleans, 21-23 February 2008. J. Invest. Med. 56: 469-470, 2008
  • Analysis of astrocyte-glioma interactions in a co-culture experimental model. Southern Regional Meetings and the Southern Society for Clinical Investigation (SSCI) annual meeting, New Orleans, 21-23 February 2008. J. Invest. Med. 56: 471, 2008.
  • Characterization of astrocytes-glioma interaction in a co-colture experimental model. Abstract Book del XXIst Meeting of the Federation of the European Connective Tissue Societies, Marsiglia, France, 9-13: 130.July 2008.
  • Dendritic cell redirection of regulatory T cell responses to ovarian cancer antigens. 24th Annual meeting of the International Society for Biological Therapy of Cancer, Washington, DC, October 2009.
  • Sperm protein 17 vaccination induces a long-term protective immune response against ovarian cancer. 24th Annual meeting of the International Society for Biological Therapy of Cancer, Washington, DC, October 2009.
  • Sp17 Protein with CpG Immunization Induces an Active Immune Response Against Ovarian Cancer in the ID8 Animal Model. Vaccine Third Global Congress, Singapore. October 2009.
  • Effective prevention and therapy of ovarian cancer with sperm protein 17 vaccination. 97th. Annual meeting of the American Association of Immunologists. Baltimore, MD, May 2010.
  • A paradigm shift in ovarian cancer immunotherapy: breaking immune tolerance redirecting T-helper differentiation with cancer/testis antigen vaccination. International Society for Biological Therapy of Cancer's (iSBTc) 25th Annual Meeting, Washington, D.C., October 2010.
  Research Interests  

No research information available online at this time.