TTUHSC School of Medicine
HomeSchool of MedicinePharmacology and NeuroscienceFaculty

Pharmacology and Neuroscience

Peter John Syapin

ABRIDGED CURRICULUM VITAE

Birthplace: Los Angeles, California, USA - February 10, 1950

Marital Status:  Married, three children

Education             

B.S. in Biological Sciences, Department of Biological Sciences, University of California at Irvine, 1969-1972

Pre-doctoral training, Junior Specialist, Centre de Neurochimie du C.N.R.S., Strasbourg, France (Drs. Paul Mandel and Guy Vincendon - hosts), 1974-1975

Ph.D. in Pharmacology and Toxicology, Department of Medical Pharmacology and Therapeutics, College of Medicine, University of California at Irvine (Dr. Ernest P. Noble - dissertation advisor), 1972-1977


Postgraduate Training

Staff Fellow, Laboratory of Preclinical Studies, National Institute on Alcohol Abuse and Alcoholism, Rockville, Maryland (Dr. Phil Skolnick -mentor), 1977-1978

Research Scholar, Grant Neuroscience Laboratory, University of Southern California School of Medicine, Los Angeles (Dr. Leslie P. Weiner -mentor), 1978-1979

Visiting Scientist, Laboratory of Neurovirology, New York University, New York, NY (Dr. Carol Shoshkes Reiss – host), 1999

Present Position             

Associate Professor of Pharmacology (with tenure)
Associate Professor of Anesthesiology (joint appointment)

Other University Affiliations

Texas Tech University Health Sciences Center Graduate School of Biomedical Sciences
Texas Tech University Institute for Biotechnology & Genomics
Texas Tech University/Howard Hughes Medical Institute Undergraduate Biological Science Education Program

Professional Experience

Assistant Professor of Pharmacology (tenure track), Texas Tech University Health Sciences Center, Lubbock, TX, 1990-1997

Associate Professor of Research in Psychiatry and the Behavioral Sciences, and Neurology (non-tenure track), University of Southern California School of Medicine, Los Angeles, CA, 1987-1990

Assistant Professor of Research in Psychiatry and the Behavioral Sciences, and Neurology (non-tenure track), University of Southern California School of Medicine, Los Angeles, CA, 1986-1987

Assistant Biochemical Pharmacologist II, Department of Psychiatry, and Behavioral Sciences, Neuropsychiatric Institute, UCLA School of Medicine, University of California, Los Angeles, 1982-1986

Assistant Professor of Research in Neurology (non-tenure track), University of Southern California School of Medicine, Los Angeles, CA, 1979-1986

Honors and Awards

ASPET Graduate Student Convocation Award
ASPET IUPHAR Travel Award
Graduation with Honors in Biological Sciences
International Society for Neurochemistry Young Investigator Travel Award
TTUHSC SOM Research Grant Incentive Award
USC Faculty Research and Innovation Fund Award

Certifications and Licensure

IRB certification #970009426
TDPS controlled substances registration # C0076659
USDJ controlled substances registration # PS 0175643

Grant Reviews

Gordon and Mary Cain Pediatric Neurology Research Foundation
National Institutes of Health
National Research Council USAID Project
National Science Foundation
United States Veterans Administration
USC Faculty Research and Innovation Award

Manuscript Reviews

Alcoholism: Clinical and Experimental Research
Biochemical Pharmacology
Brain Research
Brain Research Bulletin
Drug and Alcohol Dependence
Experimental Neurology
Hepatology
Journal of Biological Chemistry
Journal of Neurobiology
Journal of Neurochemistry
Journal of Neurosurgery
Journal of Pharmacology and Experimental Therapeutics
Life Sciences
Molecular and Chemical Neuropathology
Molecular Endocrinology
Pharmacology Biochemistry and Behavior
Proceedings of the National Academy of Sciences, U.S.A.
Psychoneuroendocrinology

Professional Affiliations

American Association for the Advancement of Science
American Society for Pharmacology and Experimental Therapeutics
International Brain Research Organization
International Society for Biomedical Research on Alcoholism
International Society for Neurochemistry
Research Society on Alcoholism
Society for Neuroscience
Texas Research Society on Alcoholism (Vice-President, 1995-1997)
The Society for Free Radical Biology and Medicine, (formerly the Oxygen Society)
Western Pharmacology Society (Councilor for Electronic Communication, 2002-2005)

Teaching Activity

University of Southern California School of Medicine
Cardiovascular Pharmacology
Medical Student Elective; Developments in Alcoholism
Neuroscience Review for Neurology Residents

Texas Tech University Health Sciences Center
Allied Health Pharmacology
Independent Research
Integrated Neurosciences
Medical Pharmacology
Molecular and Cellular Pharmacology
Neuropsychopharmacology
Pharmacology Seminar (coordinator 1993-1998)
Physician Assistant Medical Pharmacology
Principles of Pharmacology (course coordinator)
Teaching in Pharmacology
Techniques in Pharmacology Research
Introduction to Biotechnology
Bioinformatics
Biomarkers in Toxicology

Administrative Activity

University of Southern California School of Medicine
Appointed Positions
Department of Neurology Appointment & Promotion Committee
Department of Psychiatry Research Committee
USC Health and Safety Committee

Texas Tech University Health Sciences Center
Appointed Positions
Chair, Department of Pharmacology Faculty Pre-tenure Review Committee
Chair, Department of Pharmacology Tissue Culture Facility and Equipment Usage Committee
Dean’s Committee on DNA Array Technology
Department of Pharmacology Ad Hoc Computer Strategic Planning Committee
Department of Pharmacology Ad Hoc Faculty Search Committee
Department of Pharmacology Ad Hoc Committee on Undergraduate Pharmacology Course
Department of Pharmacology Master’s Committee
School of Medicine Pharmacology Chairman's Search Committee
School of Medicine Admissions Committee
School of Medicine Pharmacology Chair Search Committee
School of Medicine Faculty Appointments Committee
School of Medicine Faculty Development Leave Committee
School of Medicine LCME Institutional Self Study Task Force Clinical Teaching Facilities Sub-Committee
School of Medicine DNA Technology Steering Committee
TTUHSC Conflict of Interest Task Force
DNA Bank Research Advisory Committee

Elected Positions
School of Medicine Faculty Committee on Grading and Promotions
School of Medicine Faculty Research Committee (Chairman, 2001)

Post-Graduate Student Mentoring Activity

Ph.D. committee chair, Julius D. Militante (pharmacology program)
Ph.D. committee member, Jere Rex Lee (pharmacology program)
Ph.D. committee member, Yaqun Bao (biochemistry program; not completed)
Ph.D. qualifying exam committee, Raquelli Ganel (pharmacology program)
Ph.D. committee member, Joel D. Starnes, III (microbiology and immunology program)
M.S. committee member, Roy Hendley, (pharmacology program)
Ph.D. committee chair, Suzan Parhizgar (pharmacology program)
Ph.D. committee chair, Thomas Shiner (pharmacology program)

Other Student Training Activity

University of Southern California School of Medicine
Deborah A. Finn, Post-graduate training
Partha Nandy, Graduate student training
Irma Y. Palomares, High school student training
John H. Schneider, Jr., Senior year biology project mentor
James D. Silverman, Summer medical student training

Texas Tech University Health Sciences Center
Thomas Shiner, Graduate Student lab rotation mentor
Suzan Parhizgar, Graduate Student lab rotation mentor
Roy Hendley, Graduate Student lab rotation mentor
Jason D. Lovell, Senior year research project for molecular biology majors mentor
Randall L. Davis, Ph.D., postdoctoral research mentor
C. Brandon Law, SABR summer research mentor
David Huron, TTU/HHMI trainee; ASPET summer undergraduate research mentor
Li-qiang Ren, Ph.D., postdoctoral research mentor
Nicole Abates, ASPET summer undergraduate research mentor
Gabriel Salazar, NIH minority high school student research apprenticeship program mentor
Joseph Marney, ASPET summer undergraduate research mentor
Alexia Rendon, NIH minority high school student research apprenticeship program mentor
Elizabeth Andrews, Graduate student lab rotation mentor
Brian Perkins, ASPET summer undergraduate research mentor
Kristie Burton, ASPET summer undergraduate research mentor
Melissa L. Odom, ASPET summer undergraduate research mentor
Clarence C-H. Chao, NIH minority high school student research apprenticeship program mentor
Ronald Medley, Pharmaceutical Manufacturers Association medical student fellowship mentor
Kelly L. Klein, Medical student summer research mentor
Leonardo Sifuentes, NIH minority high school student research apprenticeship program mentor
William L. Phelps D.D.S., Summer medical student training

Consultantships

NIH teacher-investigator development award (P.I. - Stephanie S. Erlich, M.D.)
University of Texas-Houston Medical School Department of Psychiatry and Behavioral Sciences, external expert reviewer on promotion to associate professor without tenure
TTUHSC-El Paso & UTEP health careers recruitment and preparations program,
University of Illinois at Chicago, College of Medicine, Department of Anesthesiology, external expert reviewer on promotion to research associate professor

Other Academic Activities

Recipient of a Wellcome Visiting Professorship for Dr. Phil Skolnick to TTUHSC
TTUHSC commencement ceremony, faculty member in regalia
Meeting organizer, 6th annual scientific meeting of the Texas Research Society on Alcoholism
TTUHSC faculty judge for annual student research day

COMMUNITY SERVICE AND RECOGNITION

Member, Board of Trustee; The Oralingua Foundation, (President, 1980)
Member, Board of Trustee; The Oralingua School for the Hearing Impaired
Letter of Recognition, Los Angeles County Epilepsy Society, Inc.
Recognition Award for Outstanding Help and Contribution, Oralingua Foundation Chimes
Judge, 35th South Plains Regional Science and Engineering Fair
Volunteer pledge taker, local Public Broadcasting Station (KTXT-TV)

RESEARCH ACTIVITIES

Invited Conferences, Symposia and Workshops

Invited speaker; Symposium on "Benzodiazepine Receptors in the CNS", Winter Conference on Brain
Research, Sun Valley, ID
Invited participant; Winter Conference on Brain Research, Keystone, CO
Attendee, Short course on Receptor Binding Techniques, sponsored by the Society for Neuroscience,
Cincinnati, OH
Organizer, chairman and speaker; Symposium on "Receptors for Benzodiazepine Drugs; Role in Neuronal
Function", Winter Conference on Brain Research, Keystone, CO
Invited participant; Winter Conference on Brain Research, Steamboat Springs, CO
Invited participant; Conference on Pharmacology of Benzodiazepines, Organized by the National Institute
of Mental Health-Tufts New England Medical Center, Bethesda, MD
Invited speaker; Symposium on "Genetic Variability in Responsiveness to Anxiolytics and
Anticonvulsants", Winter Conference on Brain Research, Keystone, CO
Invited participant; Winter Conference on Brain Research, Vail, CO
Invited speaker, Symposium on "The Neurobiology of Panic Disorder", Winter Conference on Brain
Research, Vail, CO
Invited participant; Gordon Research Conference on Alcohol, Santa Barbara, CA
Invited participant; Winter Conference on Brain Research, Steamboat Springs, CO
Invited speaker; Conference on Ro15-4513, Organized by the National Institute on Alcohol Abuse and
Alcoholism, Bethesda, MD
Invited speaker; Symposium on "Body Temperature During Intoxication: Critical Factor in Alcohol
Research", Research Society on Alcoholism annual meeting, Wild Dunes, Charleston, SC
Invited presenter; Second Annual National Conference on Alcohol Abuse and Alcoholism, San Diego, CA Invited speaker; Symposium on "Brain, Behavior, and Stress", USC Program for Neural, Informational, and
Behavioral Sciences, Los Angeles, CA
Invited participant, Workshop on Recombinant DNA Techniques, sponsored by NIAAA and BRL Life
Technologies, University of Michigan, Ann Arbor, MI
Invited participant, Workshop on Alcohol and the Endocrine System, sponsored by NIAAA, San Diego, CA
Invited participant and poster presenter, Gordon Research Conference on Alcohol, Oxnard, CA
Invited speaker; 4th Annual Scientific Meeting of the Texas Research Society on Alcoholism, Houston, TX Invited participant and poster presenter; Gordon Research Conference on Nitric Oxide in Biochemistry and
Biology, Ventura, CA
Invited Faculty; panel speaker on "Pharmacologic and Behavioral Interventions" 19th Annual Conference
on Alcoholism and Drug Abuse, Houston, TX
Co-chairman and speaker; Symposium on "The Biological Interaction of Alcohol with Nitric Oxide",
Research Society on Alcoholism annual meeting, Steamboat Springs, CO
Invited participant; Keystone Symposia on Molecular and Cellular Biology on "Signal Transduction Through
Tyrosine Kinases" and "Signaling in Neuronal Development, Differentiation, and Degeneration",
Taos, NM
Program chairman and speaker; 6th Annual Scientific Meeting of the Texas Research Society on
Alcoholism, Lubbock, TX
Invited participant and poster presenter; Gordon Research Conference on Nitric Oxide, Ventura, CA
(unable to attendance)
Speaker; 7th Annual Scientific Meeting of the Texas Research Society on Alcoholism, Galveston, TX
Invited participant; Satellite meeting on Ethanol and Intracellular Signal Transduction, Research Society on
Alcoholism annual meeting, San Francisco, CA
Invited speaker; Symposium on "Alcohol and Nitric Oxide", Research Society on Alcoholism annual
meeting, San Francisco, CA
Invited speaker, Workshop on "Alcohol Tolerance and Sensitization", Research Society on Alcoholism
annual meeting, Hilton Head Island, SC
Organizer, chairman and speaker; Symposium on "Alcohol and NO: good guy or bad guy?", The 1998
Congress of the International Society for Biomedical Research on Alcoholism (ISBRA-98),
Copenhagen, DK
Invited participant and poster presenter; 38th annual Winter Conference on Brain Research, Snowmass
Village, CO
Invited participant; Keystone Symposia on Molecular and Cellular Biology on "Infections of the Nervous
System: Host-pathogen Interactions" and "Effectors of Inflammation in the CNS", Taos, NM
Speaker; 9th Annual Scientific Meeting of the Texas Research Society on Alcoholism, Dallas, TX
Participant, Research Society on Alcoholism Satellite Workshop on "Multiplex Hybridization Arrays and
Alcohol Research", Santa Barbara, CA
Participant, American Society for Biochemistry and Molecular Biology Fall Symposia on "Ethanol and Cell
Signaling", Lake Tahoe, CA
Invited participant, Texas Conference on the Neurobiology of Addiction 2000, Austin, TX
Invited participant, The Northwest Conference on Microarrays, Seattle, WA
Invited speaker, RSA 2001 Satellite Symposium on "New Aspects of Immunomodulation by Alcohol", Montreal, Quebec, CN
Symposium organizer and Chair, ESBRA 2001 symposium on "Alcohol Exposure and Gene Expression in the CNS", Paris, FR
Invited discussant, NIAAA sponsored workshop on "Potential Use of Stem Cells in Alcohol-related Conditions", Bethesda, MD

Other Invited Presentations

"Pharmacologic & physiologic role of benzodiazepine receptors in the central nervous system", Dept. of
Neurology, LAC-USC Medical Center, Los Angeles, CA
"Genetic influences on seizure susceptibility and response to diazepam and pentylenetetrazol", Dept. of
Pharmacology, University of New Mexico, Albuquerque, NM
"Anticonvulsant benzodiazospinoids: From behavior to bindology", Dept. of Neurology, School of
Medicine, University of Southern California, Los Angeles, CA
"Genetic influences on seizure susceptibility", Pharmaceutical Research Division, Warner-Lambert Parke-
Davis, Ann Arbor, MI
"Benzodiazepine agonist and antagonist drugs and convulsions", Neuroscience Research Seminars and
Lectures series, Brain Research Institute, University of California at Los Angeles, CA
"Pharmacological aspects of benzodiazepine receptors", School of Pharmacy, University of Southern
California, Los Angeles, CA
"The meaning of benzodiazepine receptors: isolation and partial characterization of a BZEL, the brain's
own Valium", Dept. of Neurology, School of Medicine, University of Southern California, Los
Angeles, CA
"Benzodiazepine receptor sites and their ligands", School of Pharmacy, University of Southern California,
Los Angeles, CA
"The benzodiazepine-GABA-chloride receptor complex and what it can tell us about the neurochemistry of
the brain", Neurology Dept., Kaiser Permanente of Southern California, Los Angeles, CA
"Endogenous ligands to benzodiazepine receptors", NeuroScience Club, University of Southern California,
Los Angeles, CA
"Alcohol intoxication and benzodiazepine receptors" Dept. of Pharmacology and Nutrition, School of
Medicine, University of Southern California, Los Angeles, CA
"Characteristics of peripheral-type benzodiazepine receptor subtypes", Neuroscience Research Seminars
and Lectures series, Brain Research Institute, University of California at Los Angeles, CA
"Characterization of human peripheral-type2 benzodiazepine receptors", Dept. of Pharmacology, Fort
Wayne Center for Medical Education, Indiana University School of Medicine, Fort Wayne, IN
"Characterization of peripheral type2 benzodiazepine receptors", Dept. of Pharmacology, Texas Tech
University Health Sciences Center School of Medicine, Lubbock, TX
"Receptor-ligand binding heterogeneity: Benzodiazepine receptors as examples", Health Science
Neurobiology Organization, University of Southern California, Los Angeles, CA
"Regulation of peripheral-type benzodiazepine receptors", Dept. of Biochemistry and Molecular Biology,
Texas Tech University Health Sciences Center School of Medicine, Lubbock, TX
"Reactive astrocytes", Neuroscience Research Seminar series, Texas Tech University Health Sciences
Center School of Medicine, Lubbock, TX
"The evolution of peripheral-type benzodiazepine receptors", Dept. of Physiology, Texas Tech University
Health Sciences Center School of Medicine, Lubbock, TX
"NMDA-induced neurodegeneration", Neuroscience Research Seminar series, Texas Tech University
Health Sciences Center School of Medicine, Lubbock, TX
"Nitric oxide and excitotoxicity", Neurology Grand Rounds, Texas Tech University Health Sciences Center
School of Medicine, Lubbock, TX
"Alcohol, nitric oxide and brain damage", Psychiatry Grand Rounds, Texas Tech University Health
Sciences Center School of Medicine, Lubbock, TX
"CNS glia as targets for ethanol: Studies on iNOS", NIDA/NIAAA Training Program in Biological Bases of
Substance Abuse, Department of Medical Psychology, Oregon Health Sciences University and
the Veterans Administration Medical Center, Portland, OR
"Glia as targets for ethanol", Division of Pharmacology and Toxicology, School of Pharmacy, University of
Texas at Austin, TX
"Ethanol-sensitive gene induction: Studies on glial nitric oxide synthase", Pharmacology Seminar Series,
Texas Tech University Health Sciences Center School of Medicine, Lubbock, TX
"Alcohol and glial nitric oxide synthase-2 activity" Department of Pharmaceutical Sciences, School of
Pharmacy and Allied Health Science, University of Montana, Missoula, MT
"The influence of alcohol and drugs of abuse on NOS-2 expression by glia', Department of Psychiatry,
University of Mainz, Mainz, Germany
"The influence of alcohol and drugs of abuse on NOS-2 expression by glia', Laboratoire de
Pharmacologie, Centre de Recherche Pernod Ricard, Creteil, France
"Alcohol effects on gene expression", Pharmacology Seminar Series, Texas Tech University Health Sciences Center School of Medicine, Lubbock, TX

BIBLIOGRAPHY

Original Publications

Syapin, P.J., Tewari, S. and Noble, E.P. Effects of chronic ethanol ingestion on microtubular protein of mice brains. Proc. West. Pharmacol. Soc. 17 184-187, 1974.

Syapin, P.J., Stefanovic, V., Mandel, P. and Noble, E.P. The chronic and acute effects of ethanol on adenosine triphosphatase activity in cultured astroblast and neuroblastoma cells. J. Neurosci. Res. 2: 147-155, 1976.

Noble, E.P., Syapin, P.J., Vigran, R. and Rosenberg, A. Neuraminidase-releasable surface sialic acid of cultured astroblasts exposed to ethanol. J. Neurochem. 27: 217-221, 1976.

Massarelli, R., Syapin, P.J. and Noble, E.P. Increased uptake of choline by neural cell cultures chronically exposed to ethanol. Life Sciences 18: 397-404, 1976.

Syapin, P.J. and Skolnick, P. Characteristics of benzodiazepine binding sites in cultured cells of neural origin. J. Neurochem. 32: 1047-1051, 1979.

Skolnick, P., Syapin, P.J., Paugh, B.A. and Paul, S.M. Reduction in benzodiazepine receptors associated with purkinje cell degeneration in "nervous" mutant mice. Nature 277: 397-398, 1979.

Skolnick, P., Syapin, P.J., Paugh, B.A., Moncada, V., Marangos, P.J. and Paul, S.M. Inosine, an endogenous ligand of the brain benzodiazepine receptor antagonizes pentylenetetrazole-evoked seizures. Proc. Natl. Acad. Sci., USA 76: 1515-1518, 1979.

Marangos, P.J., Paul, S.M., Parma, A.M., Goodwin, F.K., Syapin, P.J. and Skolnick, P. Purinergic inhibition of diazepam binding to rat brain (in vitro). Life Sciences 24: 851-858, 1979.

Paul, S.M., Syapin, P.J., Paugh, B.A., Moncada, V. and Skolnick, P. Correlation between receptor occupation and anticonvulsant effects of diazepam. Nature 281: 688-689, 1979.

Skolnick, P., Marangos, P.J., Syapin, P.J., Goodwin, F.K. and Paul, S.M. CNS benzodiazepine receptors: Physiological studies and putative endogenous ligands. Pharmacol. Biochem. Behav. 10: 815-823, 1979.

Syapin, P.J. and Noble, E.P. Studies on ethanol effects on cells in culture. In: Biochemistry and Pharmacology of Ethanol, vol. 1, E. Majchrowicz and E.P. Noble (eds), Plenum Press, New York, pp. 521-540, 1979.

Alkana, R.L. and Syapin, P.J. Antagonism of ethanol narcosis in mice by low level treatment with oxygen. Currents in Alcoholism 5: 165-171, 1979.

Syapin, P.J., Stefanovic, V., Mandel, P. and Noble, E.P. Stimulation of the plasma membrane enzyme 5'-nucleotidase by ethanol exposure to neural cells in culture. Prog. in Neuro-Psychopharmacology 4: 19-30, 1980.

Syapin, P.J., Stefanovic, V., Mandel, P. and Noble, E.P. Stimulation of rat C6 glioma ecto-5'-nucleotidase by chronic ethanol treatment. Biochem. Pharmacol. 29: 2279-2284, 1980.

Syapin, P.J., Tewari, S. and Noble, E.P. Effect of ethanol on neural cells grown in culture: interaction with plasma membrane ecto-5'-nucleotidase activity. In: Biological Effects of Alcohol, Advances in Experimental Medicine and Biology, vol. 126, H. Begleiter (ed.), Plenum Press, New York, pp. 283-298, 1980.

Syapin, P.J. and Rickman, D.W. Benzodiazepine receptors increase following repeated pentylenetetrazole injections. Eur. J. Pharmacol. 72: 117-120, 1981.

Syapin, P.J., Salvaterra, P.M. and Engelhardt, J.K. Neuronal-like features of TE671 cells: Presence of a functional nicotinic cholinergic receptor. Brain Res. 231: 365-377, 1982.

Syapin, P.J. Effects of the tottering mutation in the mouse: Multiple neurologic changes. Exp. Neurol. 76: 566-573, 1982.

Syapin, P.J. Inhibition of pentylenetetrazol induced genetically-determined stereotypic convulsions in tottering mice by diazepam. Pharmacol. Biochem. Behav. 18: 389-394, 1983.

Malcolm, R.D., Finn, D.A., Syapin, P.J. and Alkana, R.L. Reduced lethality from ethanol or ethanol plus pentobarbital in mice exposed to 1 or 12 atmospheres absolute helium oxygen. Psychopharmacology 86: 409-412, 1985.

Alkana, R.L., Finn, D.A., Gallesisky, G.G., Syapin, P.J. and Malcolm, R.D. Ethanol withdrawal in mice precipitated and exacerbated by hyperbaric exposure. Science 229: 772-774, 1985.

Syapin, P.J., Cole, R., De Vellis, J. and Noble, E.P. Benzodiazepine binding characteristics of embryonic rat brain neurons grown in culture. J. Neurochem. 45: 1797-1801, 1985.

Syapin, P.J., Chen, J. and Alkana, R.L. Effect of norepinephrine on inhibition of mouse brain (Na+ + K+)-stimulated, (Mg++)-dependent, and (Ca++)-dependent ATPase activities by ethanol. Alcohol 2: 145-148, 1985.

Alkana, R.L., Finn, D.A., Galleisky, G.G., Bejanian, M., Boone, D.C., Jones, B. and Syapin, P.J. Temperature modulates ethanol sensitivity in mice: Generality across strain and sex. Alcohol 2: 145-148, 1985.

Syapin, P.J. and Alkana, R.L. Ethanol-induced inhibition of mouse brain adenosine triphosphatase activities: Lack of interaction with norepinephrine in vitro. Alcoholism: Clin. Exp. Res. 10: 635-640, 1986.

Syapin, P.J., Ritchie, T., Noble, L. and Noble, E.P. Post-mortem changes in rat brain: Studies on membrane-bound enzymes and receptors. J. Neurochem. 48: 1285-1290, 1987.

Bejanian, M., Finn, D.A., Syapin, P.J. and Alkana, R.L. Rectal and brain temperatures in ethanol-intoxicated mice. Psychopharmacology 92: 301-307, 1987.

Alkana, R.L., Bejanian, M., Syapin, P.J. and Finn, D.A. Chronic functional ethanol tolerance in mice influenced by body temperature during acquisition. Life Sciences 41: 413-420, 1987.

Schneider, L.S., Syapin, P.J. and Pawluczyk, S. Seizures following triazolam withdrawal despite benzodiazepine treatment. J. Clin. Psychiatry 48: 418-419, 1987.

Syapin, P.J., Gee, K.W. and Alkana, R.L. Ro15-4513 differentially affects ethanol-induced hypnosis and hypothermia. Brain Res. Bull. 19: 603-605, 1987.

Alkana, R.L., Syapin, P.J., Galleisky, G.G. and Finn, D.A. Hyperbaric exposure acts as an ethanol antagonist: Evidence from chronic ethanol studies. In: Advances in Biomedical Alcohol Research. K.O. Lindros, R. Ylikahri and K. Kiianmaa (eds), Pergamon Press, Oxford, pp. 417-421, 1987.

Information and source for the LIGAND computer program (letter to the editor). In: Laboratory PC User, Vol. 1, No. 11, Glenn I. Ouchi, editor, BREGO Research, San Jose, CA, page 4, 1987.

Syapin, P.J. and Alkana, R.L. Chronic ethanol exposure increases peripheral-type benzodiazepine receptors in brain. Eur. J. Pharmacol. 147: 101-109, 1988.

Syapin, P.J., Chen, J., Finn, D.A. and Alkana, R.L. Antagonism of ethanol-induced depression of mouse locomotor activity by hyperbaric exposure. Life Sciences 43: 2221-2229, 1988.

Finn, D.A., Bejanian, M., Jones, B.L., Syapin, P.J. and Alkana, R.L. Temperature affects ethanol lethality in C57BL/6, 129, LS and SS mice. Pharmacol. Biochem. Behav. 34: 375-380, 1989.

Alkana, R.L., Bejanian, M., Jones, B.L., Syapin, P.J., Crabbe, J.C. and Finn, D.A. Body temperature manipulation influences genetically determined differences in ethanol sensitivity. In: Genetic Aspects of Alcoholism, vol. 37, K. Kiianmaa, B. Tabakoff, T. Saito (eds), Finn. Fnd. for Alcohol Studies, Helsinki, pp. 185-196, 1989.

Syapin, P.J. Effects of drugs on [3H]PK 11195 binding to human neuron-like cells, Proc. West. Pharmacol. Soc. 32: 255-258, 1989.

Syapin, P.J., Jones, B.J., Kobayashi, L.S., Finn, D.A. and Alkana, R.L. Interactions between benzodiazepine antagonists, inverse agonists, and the acute behavioral effects of ethanol in mice. Brain Res. Bull. 24: 705-709, 1990.

Finn, D.A., Bejanian, M., Jones, B.L., McGivern, R.F., Syapin, P.J., Crabbe, J.C. and Alkana, R.L. Body temperature differentially affects ethanol sensitivity in both inbred strains and selected lines of mice. J. Pharmacol. Exp. Ther. 253: 1229-1235, 1990.

Bejanian, M., Syapin, P.J., Finn, D.A. and Alkana, R.L. Body temperature and ethanol pharmacokinetics in temperature-challenged mice. Alcohol 7: 331-337, 1990.

Finn, D.A., Syapin, P.J., Bejanian, M., Jones, B.L. and Alkana, R.L. Body temperature influences ethanol and ethanol/pentobarbital lethality in mice. Alcohol 8: 39-41, 1991.

Bejanian, M., Alkana, R.L., von Hungen, K., Baxter, C.F. and Syapin, P.J. Temperature alters ethanol-induced fluidization in C57 mouse brain membranes. Alcohol 8: 117-121, 1991.

Alkana, R.L., DeBold, J.F., Finn, D.A., Babbini, M., and Syapin, P.J. Ethanol-induced depression of aggression in mice antagonized by hyperbaric exposure. Pharmacol. Biochem. Behav. 38: 639-644, 1991.

Bejanian, M., Jones, B.L., Syapin, P.J., Finn, D.A., and Alkana, R.L. Brain temperature and ethanol sensitivity in C57 mice: a radiotelemetric study. Pharmacol. Biochem. Behav. 39: 457-463, 1991.

Finn, D.A., Bejanian, M., Jones, B.L., Babbini, M., Syapin, P.J., and Alkana, R.L. The relationship between brain temperature during intoxication and ethanol sensitivity in LS and SS mice. Alcoholism: Clin. Exp. Res. 15: 717-724, 1991.

Alkana, R.L., Kobayashi, L.S., Jones, B.L., Finn, D.A., and Syapin, P.J. Low level hyperbaric heliox does not affect drug-induced seizure latency in mice. Ann. N.Y. Acad. Sci. 625: 770-773, 1991.

Alkana, R.L., Finn, D.A., Jones, B.L., Kobayashi, L.S., Babbini, M., and Syapin, P.J. Genetically determined differences in the antagonistic effect of pressure on ethanol induced loss of righting reflex in mice. Alcoholism: Clin. Exp. Res. 16: 17-22, 1992.

Militante, J.D. and Syapin, P.J. Regulation of human peripheral-type benzodiazepine receptors: Effect of 3-amino-1,2,4-triazole. Proc. West. Pharmacol. Soc. 36: 197-202, 1993.

Finn, D.A., Syapin, P.J., Bejanian, M., Jones, B.L., and Alkana, R.L., Temperature dependence of ethanol depression in mice: dose response, Alcoholism: Clin. Exp. Res. 18: 382-386, 1994.

Syapin, P.J., Ethanol inhibition of inducible nitric oxide synthase activity in C6 glioma cells. Alcoholism: Clin. Exp. Res. 19: 262-267, 1995.

Syapin, P.J., Jones, B.L., Finn, D.A., Davies, D.L. and Alkana, R.L., Effect of 12 atmospheres helium-oxygen on the response of mice to convulsant drugs. Undersea & Hyperbaric Med. 23: 35-41, 1996.

Militante, J.D., Feinstein, D. L., and Syapin, P.J., Suppression by ethanol of inducible nitric oxide synthase expression in C6 glioma cells. J. Pharmacol. Exp. Ther., 281: 558-565, 1997.

Syapin, P.J. Alcohol and inducible gene expression in brain cells. Texas Research Society on Alcoholism Newsletter 7(4): 2-4, 1997.

Syapin, P.J., Alcohol and nitric oxide production by cells of the brain. Alcohol, 16: 159-165, 1998.

Syapin, P.J., Rendon, A., Huron, D.R., and Militante, J.D., Effects of short chain alkanols on the inducible nitric oxide synthase in a glial cell line. Brit. J. Pharmacol. 126: 1253-1261, 1999.

Ren, L.-Q., Garrett, D.K. Syapin, M. and Syapin, P.J. Differential fibronectin expression in activated C6 glial cells treated with ethanol. Molec. Pharmacol. 58: 1303-1309, 2000.

Syapin, P.J., J.D. Militante, Garrett, D.K., and Ren, L.-Q., Cytokine-induced iNOS expression in C6 glial cells: Transcriptional inhibition by ethanol. J. Pharm. Exp. Ther. 298, 744-752, 2001.

Lado-Abeal, J., Clapper, J.A., Zhu, B.C., Hough, C.M., Syapin, P.J. and Norman, R.L. Hypoglycemia-induced suppression of luteinizing hormone secretion in intact female rhesus macaques: Role of vasopressin and endogenous opioids. Stress, 5, 113-119, 2002.

Ren, L. and Syapin, P.J., Dual mechanisms for ethanol inhibition of Monocyte Chemotactic Protein-3 mRNA in activated glial cells. J. Pharmacol. Exp. Ther. 303 :110-116, 2002. 

Davis, R.L., Dertien, J. and Syapin, P.J., Ethanol-induced modulation of inducible nitric-oxide synthase activity in human A172 astrocytoma cells. Alcohol. Clin. Exp. Res. 26: 1414-1421, 2002.

King, S.R., Manna, P.R., Ishii, T., Syapin, P.J., Ginsberg, S.D., Wilson, K., Walsh, L.P., Parker, K.L., Stocco, D.M., Smith, R.G., and Lamb, D.J., Steroidogenic Acute Regulatory (StAR) protein mRNA and protein are expressed in neurons and glia in discrete regions of the brain. J. Neurosci. 22: 10613-10620, 2002.

Rao, R.M., Youngah, J., Babb-Tarbox, M., Syapin, P.J., and Stocco, D.M., Regulation of steroid hormone biosynthesis in R2C and MA-10 Leydig tumor cells: role of the cholersterol transfer proteins StAR and PBR. Endo. Res. 28: 387-394, 2002.

Sanchez, A.C., Davis, R.L., and Syapin, P.J., Identification of cis-regulatory regions necessary for robust NOS2 promoter activity in glial cells: Indirect role for NF-kB. J. Neurochem. submitted, 2003.

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Last updated April 9, 2003

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