TTUHSC School of Medicine
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Dr. Susan E. Bergeson

Associate Professor
Pharmacology and Neuroscience


Ph.D., 1997 - Oregon Health & Science University

South Plains Alcohol & Addiction Research Center
https://www.ttuhsc.edu/centers/spaarc/

Laura W. Bush Institute for Women's Health
http://www.ttuhsc.edu/laurawbushinstitute/

Office:  5C105
Phone:  806-743-2425, ext. 257
Lab:  5C195
Lab Phone:  ext. 241
FAX:  806-743-2744
E-mail:  Susan.Bergeson@TTUHSC.edu

Curriculum Vitae

Genetics and Molecular Neurobiology of Alcohol Abuse and Alcoholism:

The Bergeson lab uses a combination of behavioral, biochemical, molecular and pharmacological approaches to study the genetics of predisposition, and the molecular neurobiology of alcohol abuse and alcoholism.  Through our use of microarray and bioinformatics technology, global transcriptional analyses of several genetic mouse models of alcohol drinking and dependence have uncovered new genes and biological pathways not previously known to be involved in alcohol-related behaviors and responses.  We have also recently shown that chromatin remodeling and miRNA expression play a role in the differential transcriptional response to alcohol drinking seen between adolescent and adult mice.   The current goals of the lab focus on:  1) alcohol-induced mRNA and miRNA transcriptome changes, 2) epigenetic consequences of alcohol drinking, 3) the B2m proteome and its role in predisposition, 4) age-specific differences in alcohol mediated molecular neuroadaptation, 5) sexual dimorphic responses to alcohol, and in general, 6) the genetics of alcoholism.  Trainees have an opportunity to gain experience in a broad repertoire of laboratory technology.

Significant gene expression is divergent between high and low alcohol drinking mice, and apparent in mice congenic for a large region of chromosome nine. See: Mulligan and Ponomarev et al., PNAS. The up- and down- divergent expression pattern suggested a role for epigenetic chromatin remodeling. Scn4b has now been shown to be regulated through histone H4 acetylation in alcohol drinking mice.
Significant gene expression is divergent between high and low alcohol drinking mice, and apparent in mice congenic for a large region of chromosome nine. See: Mulligan and Ponomarev et al., PNAS. The up- and down- divergent expression pattern suggested a role for epigenetic chromatin remodeling. Scn4b has now been shown to be regulated through histone H4 acetylation in alcohol drinking mice.
Alcohol-related transcriptome remodeling is evident across a 24 hour period in six brain regions following a standard dependence-inducing intoxication protocol. Significant expression changes are shown as a raster display using CLUSTER.  Biologically relevant profiles were categorized based on significant fit to a PLS (partial least squares) pattern.
Alcohol-related transcriptome remodeling is evident across a 24 hour period in six brain regions following a standard dependence-inducing intoxication protocol. Significant expression changes are shown as a raster display using CLUSTER.  Biologically relevant profiles were categorized based on significant fit to a PLS (partial least squares) pattern.

For a complete list of publications by Susan E. Bergeson in PubMed, click here

For further information contact Dr. Susan E. Bergeson

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