Pharmacology and Neuroscience
Dr. Lynn T. Frame
Assistant Professor of Pharmacology
Ph.D., University of Arkansas for Medical Sciences
Dr. Lynn Frame currently serves as assistant professor in the Department of Pharmacology,
Texas Tech University Health Sciences Center. Dr. Frame held postdoctoral fellowships
at the National Center for Toxicological Research NCTR), the University of Arkansas
for Health Sciences (UAMS), and The Institute of Environmental and Human Health before
receiving her faculty appointment in the Department of Pharmacology at TTUHSC.
Dr. Frame received her Bachelor of Arts in Biology from the University of Virginia,
her Master of Science degree in zoology from Virginia Tech University, and her Ph.D.
in toxicology from University of Arkansas for Medical Sciences under the direction
of Dr. Julian Leakey. For her dissertation, she cloned several human xenobiotic-metabolizing
enzymes into human lymphoblastoid cell lines to model human metabolism in vitro. These
cell lines are now sold commercially. Her postdoctoral advisors included Fred Kadlubar
PhD (NCTR) and Nicholas Lang MD (Oncology, UAMS), who introduced her to the field
of cancer molecular epidemiology.
In her research, Dr. Frame attempts to understand toxicological mechanisms and genetic
risk factors that are important for chronic low-level toxicant exposures in humans.
She uses molecular biological techniques to examine genetic polymorphisms of xenobiotic-metabolizing
enzymes in exposed human populations. She also examines differences in expression
of certain enzymes that appear to play a role in risk for age-associated diseases,
including cancer, Alzheimer’s, and Parkinson’s disease. Animal models are used to
study low-level responses to environmental contaminants that may adversely affect
neurological health in humans. Currently, she is exploring the significance of dioxin-induced
alterations in circadian rhythms.
Kendall RJ, Anderson TA, Baker RJ, Bens CM, Carr JA, Chiodo LA, Dickerson RL, Dixon
KR, Frame LT, Hooper MK, Martin CF, McMurry ST, Patino R, Smith EE, Theodorakis CW
(2001) Chapter 30-Ecotoxicology, Casarett and Doule's Toxicology
Frame LT, Ozawa S, Nowell SA, Chou H-C, DeLongchamp RR, Doerge DR, Lang NP, and Kadlubar
FF (2000). A simple colorimetric assay for phenotyping the major human thermostable
phenol sulfotransferase (SULT1A1) using platelet cytosols. Drug Metabolism and Disposition.
Frame LT, Ambrosone CB, Kadlubar FF, and NP Lang (1998) Host-environment interactions
that impact on interindividual variability in susceptibility to human cancer. In:
Human variability in response to chemical exposures: measures, modeling and risk assessment
(eds: Neuman DA and Kimmel CA) International Life Sciences Institute (ILSI) publication,
CRC Press, Boca Raton, FL. pp. 165-204
Miller JD, Settachan D, Frame LT, and Dickerson RL (1999) 2,3,7,8-tetrachlorodibenzo-p-dioxin
phase advances the deer mouse (Peromyscus maniculatus) circadian rhythm by altering
expression of clock proteins. Organohalogen Compounds 42: 23-28
Frame, LT, Settachan D, and Dickerson RL (1999) 4,4-dichlorodiphenylethylene (4,4-DDE
is a 3-methylcholanthrene-type inducer in the deer mouse (Peromyscus maniculatus)
but an Aroclor-like inducer in the vole (Microtus ochrogastor). Organohalogen Compounds
Little JM, Lester R, Kuipers F, Vonk R, Mackenzie PI, Drake RR, Frame L, and Radominska-Pandya
A (1999) Variability of human hepatic UDP-glucuronosyltransferase activity. Acta Biochimica
Polonica, 46(2):351-63, 1999
Nowell SA, Leakey JEA, Warren, JF, Lang NP, and LT Frame (1998) Identification of
enzymes responsible for the metabolism of heme in human platelets. J. Biol. Chem.
1998 273: 33342-46
Bowyer JF, Frame LT, Clausing P, Nagamoto-Combs K, Osterhout CA, Sterling CR, and
AW Tank (1998) Long-term effects of amphetamine neurotoxicity on tyrosine hydroxylase
mRNA and protein in aged rats. Journal of Pharmacology & Experimental Therapeutics.
For further information contact Dr. Lynn T. Frame