Pharmacology and Neuroscience
Dr. Arthur S. Freeman - Joint Appointment
Associate Professor of Pharmacology
Ph.D., 1982, Virginia Commonwealth University
Electrophysiological and Neurochemical Pharmacology of Midbrain Dopaminergic Neurons
Several neurological and psychiatric disorders are associated with altered function
of midbrain dopamine (DA)-containing neurons. Treatment of DA-linked disorders with
DA agonists or antagonists, however, is not always effective and is accompanied by
undesirable side-effects. A great deal of basic research has focused on the autoregulatory
role of DA on DA cell function. Continued investigation into the regulation of these
neurons may ultimately yield alternative strategies to pharmacologically manipulate
their function for therapeutic benefit.
Studies in our laboratory evaluate the effects of chronic administration of antipsychotic
drugs on DA cell electrophysiology in rats. In particular, these studies assess the
effects of promising antipsychotic drug candidates in comparison to benchmark compounds.
The profile of effects for each drug often gives an indication if it will have therapeutic
efficacy and if it is likely to produce motor side-effects in humans. Current studies
also involve testing the hypothesis that diet may influence the responses of DA neurons
to drug administration. This has clincial implications, such as predicting variable
responses of patients with eating disorders to dopaminergic drugs.
For a complete list of publications by Arthur S. Freeman in PubMed, click here
For further information contact Dr.Arthur S. Freeman