Pharmacology and Neuroscience
Dr. Susan E. Bergeson
Department of Pharmacology and Neuroscience
Graduate Student Adviser
Ph.D., 1997 - Oregon Health & Science University
South Plains Alcohol & Addiction Research Center
Laura W. Bush Institute for Women's Health
Lab Phone: 806-743-3497
Genetics and Molecular Neurobiology of Alcohol Abuse and Alcoholism:
The Bergeson lab uses a combination of behavioral, biochemical, molecular and pharmacological approaches to study the genetics of predisposition, and the molecular neurobiology of alcohol abuse and alcoholism. Through our use of bioinformatics technology, global transcriptional analyses of several genetic mouse models of alcohol drinking and dependence have uncovered new genes and biological pathways not previously known to be involved in alcohol-related behaviors and responses. We have also recently uncovered that chromatin remodeling and miRNA expression play a role in the differential transcriptional response to alcohol drinking seen between adolescent and adult mice. The current goals of the lab focus on: 1) alcohol-induced mRNA and miRNA transcriptome changes, 2) epigenetic consequences of alcohol drinking (histone modifications, H3.3 substitution and DNA methylation changes), 3) translational therapies targeting neuroimmune-related high alcohol consumption, 4) age-specific differences in alcohol mediated molecular neuroadaptation, 5) sexual dimorphic responses to alcohol, and in general, 6) the genetics of alcoholism. Trainees have an opportunity to gain experience in a broad repertoire of laboratory technologies.
NIH, 1R21 AA021142 - Neuroimmune Interactions in High Alcohol Drinking
Laura Bush Institute for Women's Health - Sex and Gender-Based Medicine Triads
Texas Tech University Transdisciplinary Research Academy - System-based transdisciplinary approaches by "omics and bioinformatics" tools to identify biomarkers of at risk and progression of type I diabetes.
For a list of publications by Dr. Bergeson in PubMed, click here
For further information contact: Dr. Susan E. Bergeson