Pharmacology and Neuroscience
Dr. Susan E. Bergeson
Department of Pharmacology and Neuroscience
Graduate Student Adviser
Ph.D., 1997 - Oregon Health & Science University
Laura W. Bush Institute for Women's Health
Lab Phone: 806-743-3497
Genetics and Molecular Neurobiology of Alcohol Abuse and Alcoholism:
Through the use of bioinformatics technology applied to global mRNA and miRNA analyses of several genetic mouse models of alcohol consumption and dependence, Dr. Susan Bergeson's lab, together with her collaborators, have uncovered new genes and biological pathways not previously known to be involved in alcohol-related behaviors and responses. A recent, important contribution to the field was the identification of age-divergent alcohol-induced neuroimmune responses as a druggable target in adult high-alcohol consuming mice. The lab has successfully tested neuromodulatory drugs that significantly reduced drinking in adult mice, but whose effects are apparently blocked by miRNA expression changes in the adolescent brain. As one of few alcohol researchers focused on sex as an important factor in alcohol responses, Dr. Bergeson has identified differences in consumption and dependence at the behavioral, physiological, molecular and epigenetic levels. Most importantly, variation between females and males in the pharmacological efficacy to reduce the negative aspects of alcohol has been identified. The long-term goal of the lab is to use an amalgamation of behavioral, biochemical, molecular, neuroanatomical and pharmacological methods to better understand and treat Alcohol Use Disorders with a personalized, sex-specific, medications approach.
NIH, 1R21 AA021142 - Neuroimmune Interactions in High Alcohol Drinking
Laura Bush Institute for Women's Health - Sex and Gender-Based Medicine Triads
Texas Tech University Transdisciplinary Research Academy - System-based transdisciplinary approaches by "omics and bioinformatics" tools to identify biomarkers of at risk and progression of type I diabetes.
For a list of publications by Dr. Bergeson in PubMed, click here
For further information contact: Dr. Susan E. Bergeson