Pharmacology and Neuroscience
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Research Interests
Neurobiological underpinnings of alcohol abuse and alcoholism. Role of microglia and astrocytes in drug abuse.
Current projects | Selected publications | Laboratory | Curriculum Vitae
Current Projects
Many opportunities are available through my association with the South Plains Alcohol and Addiction Research Center including work on mechanisms of alcohol-induced brain damage, glial cell control of high alcohol drinking, development of novel anti-drinking drugs, and the role of the Tspo (peripheral-type benzodiazepine receptor) protein in neuroinflammation and brain damage.
Selected Publications
- Agrawal, R.G., Hewetson, A., George, C.M., Syapin, P.J., and Bergeson, S.E., Minocycline reduces ethanol drinking. Brain Behav. Immun., 25: S165-S169, 2011
- Syapin, P.J.,Brain Damage and Alcohol Dependence: How one may influence the other. Alcohol. Treat. Q., 29: 132-145, 2011
- Syapin, P.J., Regulation of heme oxygenase-1 for treatment of neuroinflammation and brain disorders. Brit. J. Pharmacol. 155: 623–640, 2008
- Sanchez, A.C., Davis, R.L., and Syapin, P.J. The Oct DNA motif participates in the alcohol inhibition of the inducible nitric oxide synthase gene promoter in rat C6 glioma cells. Brain Res. 1179: 16-27, 2007
- Karri, SriTulasi, Dertien, J.S., Stocco, D.M., and Syapin, P.J., StAR protein expression and pregnenolone synthesis in rat astrocytes, J. Neuroendocrinol. 19: 860-869, 2007
- Davis, R.L. and Syapin, P.J., Interactions of alcohol and nitric-oxide synthase in the brain, Brain Res. Rev. 49: 494-504, 2005
- Syapin, P.J., Hickey, W.F. and Kane, C.J.M., Alcohol brain damage and neuroinflammation: Is there a connection? Alcoholism: Clin. Exp. Res. 29, 1080-1089, 2005
- Davis, R.L. and Syapin, P.J., Ethanol increases nuclear factor-κB activity in human astroglial cells. Neurosci. Lett. 371: 128-132, 2004
- Davis, R.L. and Syapin, P.J., Chronic ethanol inhibits CXC chemokine ligand 10 production in human A172 astroglia and astroglial-mediated leukocyte chemotaxis. Neurosci. Lett. 362: 220-225, 2004
- Davis, R.L. And Syapin, P.J., Acute ethanol exposure modulates expression of inducible nitric-oxide synthase in human astroglia: Evidence for a transcriptional mechanism. Alcohol, 32: 195-202, 2004
- Sanchez, A.C., Davis, R.L., and Syapin, P.J., Identification of cis-regulatory regions necessary for robust NOS2 promoter activity in glial cells: Indirect role of NF-kB. J. Neurochem. 86: 1379-1390, 2003
- King, S.R., Manna, P.R., Ishii, T., Syapin, P.J., Ginsberg, S.D., Wilson, K., Walsh, L.P., Parker, K.L. Stocco, D.M., Smith, R.G., and Lamb, D.J. An essential component in steroid synthesis, the Steroidogenic Acute Regulatory protein, is expressed in discrete regions of the brain. J. Neurosci. 22: 10613-10620, 2002
- Alkana, R.L., Finn, D.A., Gallesisky, G.G., Syapin, P.J. and Malcolm, R.D. Ethanol withdrawal in mice precipitated and exacerbated by hyperbaric exposure. Science 229: 772-774, 1985
- Paul, S.M., Syapin, P.J., Paugh, B.A., Moncada, V. and Skolnick, P. Correlation between receptor occupation and anticonvulsant effects of diazepam. Nature 281: 688-689, 1979
Link to: SPAARC