Structure/function analysis of Cx43 gap-junctional channels: The major goals are to identify the pore-lining residues and to understand the mechanisms of regulation of solute permeability at the molecular level.
Mechanism of deafness caused by mutations of the cochlear Cx26: The goal of this project is to elucidate the molecular mechanisms of deafness caused by mutations of Cx26.
Molecular mechanism of ABC exporters: The goal of this project is to determine how different domains of the proteins move during the transport cycle.
To address the issues above, we use a variety of methodologies, including molecular biological (mutagenesis), biochemical (protein purification and reconstitution), physiological (transport assays) and biophysical (electrophysiology, fluorescence, luminescence resonance energy transfer) techniques.
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