TTUHSC School of Medicine
HomeSchool of MedicineCell Physiology and Molecular BiophysicsFaculty

Ongoing Projects

  • Structure/function analysis of Cx43 gap-junctional channels: The major goals are to identify the pore-lining residues and to understand the mechanisms of regulation of solute permeability at the molecular level.
  • Mechanism of deafness caused by mutations of the cochlear Cx26: The goal of this project is to elucidate the molecular mechanisms of deafness caused by mutations of Cx26.
  • Molecular mechanism of ABC exporters: The goal of this project is to determine how different domains of the proteins move during the transport cycle.

    To address the issues above, we use a variety of methodologies, including molecular biological (mutagenesis), biochemical (protein purification and reconstitution), physiological (transport assays) and biophysical (electrophysiology, fluorescence, luminescence resonance energy transfer) techniques.

Altenberg Homepage Laboratory Recent Publications Pubmed CMPR Useful Links