TTUHSC School of Medicine
HomeSchool of MedicineCell Physiology and Molecular BiophysicsFaculty

Cell Physiology and Molecular Biophysics



Luis G. Cuello Ph.D

   Associate Professor

Cell Physiology and Molecular Biophysics









-Laboratory web site


Department of Cell Physiology

Texas Tech University Health Sciences Center

3601 4th Street, STOP 6551

Lubbock, Texas 79430

Office: (806) 743-2525

Lab: (806) 743-2527

FAX: (806) 743-1512

Research Interests
I have been trained in the use of several biophysical techniques (electrophysiology, spectroscopy and X-ray crystallography) with the aim to understand at the molecular level the intricate relationship between membrane protein structure and function, with special attention to potassium channels. The application of these techniques in tandem have produced the first structural driven kinetic cycle for a potassium channel, which is a crucial technical achievement that would help us to elucidate the molecular basis of channel related diseases and in the "smart" design of new drugs for therapeutic purposes.




  • Recent Publications:

  • Zhao, R., Dai, H., Mendelman, N., Cuello, L.G., Chill, J.H. and Goldstein, S.A. Designer and natural peptide toxin blockers of the KcsA potassium channel identified by phage display. PNAS. 2015. Dec 15; 112(50)
  • Fiori, M.C., Krishnan, S., Corted, D.M., Retamal, M.A., Reuss, L., Altenberg, G.A. and Cuello, L.G. Functional hemichannels formed by human connexin 26 expressed in bacteria. Biosci Rep. 2015 Mar 18; 35.  
  • Fiori, M.C, Reuss, L., Cuello, L.G. and Altenberg, G.A. Functional analysis and regulation of purified connexin hemichannels. Front Physiol. 2014 Feb 25;5-71.
  • Randich, A.M., Cuello, L.G., Wanderling, S.S., Perozo, E. Biochemical and structural analysis of the hyper polarization-activated K+ channel MVP. Biochemistry. Mar 18; 53 (10) 1627-36.
  • Gonzalez-Gutierrez G, Cuello LG, Nair SK, Grosman C. Gating of the proton-gated ion channel from Gloeobacter violates at pH 4 as revealed by X-ray crystallography. PNAS. 2013. Nov 12; 110 (46): 18716-21.
  • Selected Publications: (10 out of 25)
  • Uysal, S.; Cuello, L.G.; Cortes, D.M.; Koide, S.; Kossiakoff, A.A. and Perozo, E. Mechanism of activation gating in the full -length KcsA K+ channel. PNAS. 2011, Jul 19; 108 (29): 11896-9.
  • Cuello, L.G.; Jogini, V.; Cortes, D.M. and Perozo, E. Structural mechanism of C-type inactivation in K+ channels. Nature, 2010, Jul 8;466(7303):203-8.
  • Cuello, L.G.; Jogini, V.; Cortes, D.M.; Pan, A.C.; Gagnon, D.G.; Dalmas, O.; Cordero-Morales, J.F.; Chakrapani, S.; Roux, B. and Perozo, E. Structural basis for the coupling between activation and inactivation gates in K+ channels. Nature. 2010, Jul 8;466(7303):272-5.
  • Cuello L.G.; Jogini, V.; Cortes D.M.; Sompornpisut A.; Purdy, M.D.; Wiener, M.C. and Perozo E. Design and characterization of a constitutively open KcsA. FEBS Letter. 2010 19 March 2010, Vol 584, Issue 6: 1133-1138.
  • Cuello L.G.; Cortes D.M.; Jogini V.; Sompornpisu,t A, and  Perozo E. A molecular meachanism for proton-dependent gating in KcsA. FEBS Letter. 2010 19 March 2010, Vol 584, Issue 6: 1126-1132.
  • Cordero, J; Cuello, L.G.; Zhao, Y; Jogini V, Chakrapani, S; Roux, B and Perozo, E. Molecular Determinants of Gating at the Potassium Channel Selectivity Filter.Nature Structural and Molecular Biology. Mar 12 2006.
  • Cuello L.G.; Cortes DM, Perozo E. Molecular architecture of the KvAP voltage-dependent K+ channel in a lipid bilayer. Science. 2004 Oct 15;306 (5695):491-5.
  • Perozo, E., Cortes, D.M. and Cuello, L.G. Structural Rearrangements Underlying K+ Channel Activation Gating. Science 1999. 285: 73-78.
  • Perozo, E., Cortes, D.M. and Cuello, L.G. Three-dimensional architecture and gating mechanism of a K+ channel studied by EPR spectroscopy. Nature Structure Biology 1998. 5:459-469.
  • Cuello, L.G., Romero, J.G., Cortes, D.M., Perozo, E. pH-dependent gating in the Streptomyces lividans K+ Channel. Biochemistry 1998. 37: 3229-3236.