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Cell Physiology and Molecular Biophysics

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Photograph of Dr. Jansen

Michaela Jansen, Pharm.D., Ph.D.

Assistant Professor of Cell Physiology and Molecular Biophysics

1997 Pharm.D. - Johannes Gutenberg University, Mainz, Germany

2001 Ph.D. - Johannes Gutenberg University, Mainz, Germany


Department of Cell Physiology and Molecular Biophysics
Texas Tech University Health Sciences Center
3601 4th Street, STOP 6551
Lubbock, Texas 79430
Phone: (806) 743-4059
FAX: (806) 743-1512
Email: michaela DOT jansen AT ttuhsc DOT edu


Research Interests


Research in the Jansen laboratory focuses on structure and function studies of diverse membrane proteins, specifically, ligand-gated ion channels and transporters.

We use biophysical (electrophysiology, spectroscopy, X-ray crystallography) and biochemical methods to study these proteins at a molecular level.

We are especially interested in the superfamily of pentameric ligand-gated ion channels (pLGIC) that includes the nACh, GABA, 5HT3, and Gly families. The pLGICs function mainly as neurotransmitter receptors, transforming the chemical signal contained in the neurotransmitter into an electrical signal.

Funding

Current and past funding from the following sources is gratefully acknowledged:

South Plains Foundation research grant program

CMPR at TTUHSC/TTU

Office of Research at TTUHSC


Recent Publications

2013

NCBI

Duddempudi PK, Nakashe P, Blanton MP, Jansen M. The Monomeric State of the Proton-Coupled Folate Transporter Represents the Functional Unit in the Plasma Membrane. FEBS J 2013. 280: 2900-2915.

NCBI

Mnatsakanyan N, Jansen M. Experimental determination of the vertical alignment between the second and third transmembrane segments of muscle nicotinic acetylcholine receptors. J Neurochem 2013. 125: 843-854.

NCBI

Labriola JM, Pandhare A, Jansen M, Blanton MP, Corringer PJ, Baenziger JE. Structural sensitivity of a prokaryotic pentameric ligand-gated ion channel to its membrane environment. J Biol Chem 2013. 286:11294-11303.

2012

NCBI

Pandhare A, Hamouda AK, Staggs B, Aggarwal S, Duddempudi PK, Lever JR, Lapinsky DJ, Jansen M, Cohen JB, Blanton MP. Bupropion Binds to Two Sites in the Torpedo Nicotinic Acetylcholine Receptor Transmembrane Domain: A Photoaffinity Labeling Study with the Bupropion Analog [125I]-SADU-3-72. Biochemistry 2012 51(12): 2425-2435.

2011 and earlier

NCBI

Goyal R, Salahudeen A, Jansen M. Engineering a prokaryotic Cys-loop receptor with a third functional domain. J Biol Chem 2011 286(40): 34635-34642.

NCBI

Bauman A, Piel M, Hohnemann S, Krauss A, Jansen M, Solbach C, Dannhardt G, Rosch F. Synthesis, labelling and evaluation of hydantoin-substituted indole carboxylic acids as potential ligands for PET-Imaging of the glycine binding site of the NMDA-receptor. J Label Compd Radiopharm 201154: 645-656.

NCBI

Bali M, Jansen M, Akabas MH. GABA-induced intersubunit conformational movement in the GABAA receptor alpha1M1-beta2M3 transmembrane subunit interface: experimental basis for homology modeling of an intravenous anesthetic binding site. J Neurosci 2009 Mar 11; 29(10): 3083-3092.

NCBI

Wiltfong RE, Jansen M. Probing Protein Packing Surrounding the Residues in and Flanking the Nicotinic Acetylcholine Receptor M2M3 Loop. J Neurosci 2009 Feb 11; 29(6): 1626-1635.

NCBI

Jansen M, Rabe H, Strehle A, Dieler S, Debus F, Dannhardt G, Akabas MH, Luddens H. Synthesis of GABAA Receptor Agonists and Evaluation of their alpha-Subunit Selectivity and Orientation in the GABA Binding Site. J Med Chem 2008 Aug 14; 51(15):4430-4448. Supporting Info

NCBI

Zhao R, Qiu A, Tsai E, Jansen M, Akabas MH, Goldman ID. The proton-coupled folate transporter: impact on pemetrexed transport and on antifolates activities compared with the reduced folate carrier. Mol Pharm 2008 Sep; 74(3):854-862.

NCBI

Jansen M, Bali M, Akabas MH. Modular Design of Cys-loop Ligand-Gated Ion Channels: Functional 5-HT3 and GABA rho1 Receptors Lacking the Large Cytoplasmic M3-M4 Loop. J Gen Physiol 2008 Feb; 131(2):137-146.

NCBI

Qiu A, Min S, Jansen M, Malhotra U, Tsai E, Cabelof DC, Matherly L, Zhao R, Akabas MH, Goldman ID. Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, response to dietary folate restriction. Am J Physiol - Cell Physiol 2007 Nov; 293(5):C1669-78.

NCBI

Qiu A, Jansen M, Sakaris A, Min SH, Chattopadhyay S, Tsai E, Sandoval C, Zhao R, Akabas MH, Goldman ID. Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption. Cell 2006 Dec 1;127(5):917-28.

NCBI

Jansen M, Akabas MH. State-dependent cross-linking of the M2 and M3 segments: functional basis for the alignment of GABAA and acetylcholine receptor M3 segments. J Neurosci 2006 Apr 26;26(17):4492-9.

NCBI

Reeves DC, Jansen M, Bali M, Lemster T, Akabas MH. A Role for the beta1-beta2 Loop in the Gating of 5-HT3 Receptors. J Neurosci 2005 25 (41); 9358-9366.


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Last revised, 9th of September 2013

 

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