Jansen Laboratory - Publications

	Goyal R, Salahudeen A, Jansen M. Engineering a prokaryotic Cys-loop receptor with a third functional domain. J Biol Chem 2011In Press
	Bauman A, Piel M, Hohnemann S, Krauss A, Jansen M, Solbach C, Dannhardt G, Rosch F. Synthesis, labelling and evaluation of hydantoin-substituted indole carboxylic acids as potential ligands for PET-Imaging of the glycine binding site of the NMDA-receptor.J Label Compd. Radiopharm 2011 In Press.
	Bali M, Jansen M, Akabas MH. GABA-induced intersubunit conformational movement in the GABA_A receptor alpha1M1-beta2M3 transmembrane subunit interface: experimental basis for homology modeling of an intravenous anesthetic binding site. J Neurosci 2009 Mar 11; 29(10):3083-3092.
	Wiltfong R, Jansen M. Probing Protein Packing Surrounding the Residues in and Flanking the Nicotinic Acetylcholine Receptor M2M3 Loop.J Neurosci 2009 Feb 11; 29(6):1626-1635.
	Jansen M, Rabe H, Strehle A, Dieler S, Debus F, Dannhardt G, Akabas MH, Luddens H. Synthesis of GABAA Receptor Agonists and Evaluation of their alpha-Subunit Selectivity and Orientation in the GABA Binding Site.J Med Chem 2008 Aug 14; 51(15):4430-4448. Supporting Info
	Zhao R, Qiu A, Tsai E, Jansen M, Akabas MH, Goldman ID. The Proton-Coupled Folate Transporter (PCFT): Impact on Pemetrexed Transport and on Antifolates Activities as Compared to the Reduced Folate Carrier.Mol Pharm 2008 Sep; 74(3):854-862
	Jansen M, Bali M, Akabas MH. Modular Design of Cys-loop Ligand-Gated Ion Channels: Functional 5-HT3 and GABA rho1 Receptors Lacking the Large Cytoplasmic M3-M4 Loop. J Gen Physiol 2008 Feb; 131(2):137-146
	Qiu A, Min s, Jansen M, Malhotra U, Tsai E, Cabelof DC, Matherly L, Zhao R, Akabas MH, Goldman ID. Rodent intestinal folate transporters (SLC46A1): secondary structure, functional properties, response to dietary folate restriction. Am J Physiol - Cell Physiol 2007 Nov; 293(5):C1669-78.
	Qiu A, Jansen M, Sakaris A, Min SH, Chattopadhyay S, Tsai E, Sandoval C, Zhao R, Akabas MH, Goldman ID. Identification of an intestinal folate transporter and the molecular basis for hereditary folate malabsorption. Cell 2006 Dec 1; 127(5):917-28.
	Jansen M, Akabas MH. State-dependent cross-linking of the M2 and M3 segments: functional basis for the alignment of GABA_A and acetylcholine receptor M3 segments. J Neurosci 2006 Apr 26; 26(17):4492-9.
	Pindur U, Jansen M, Lemster T. Advances in DNA-Ligands with Groove Binding, Intercalating and/or Alkylating Activity: Chemistry, DNA-Binding and Biology. Curr Med Chem 2005, 12(24):2805-2847.
	Reeves DC, Jansen M, Bali M, Lemster T, Akabas MH. A Role for the beta₁-beta₂ Loop in the Gating of 5-HT3 Receptors. J Neurosci 2005, 25(41):9358-9366.
	Jansen M, Dannhardt G. Variations of acidic functions at position 2 and substituents at positions 4, 5 and 6 of the indole moiety and their effect on NMDA-glycine site affinity, Eur J Med Chem 2003, 38(10):855-865
	Jansen M, Dannhardt G. Antagonists and agonists at the glycine site of the NMDA receptor for therapeutic interventions, Eur J Med Chem 2003, 38(7-8):661-670
	Jansen M, Potschka H, Brandt C, Dannhardt G, Loescher W. Hydantoin substituted 4,6-dichloroindole-2-carboxylic Acids as Ligands with high affinity for the Glycine Binding Site of the NMDA Receptor, J Med Chem 2003, 46(1):64-73
	Piel M, Schirrmacher R, Hoehnemann S, Hamkens W, Kohl B, Jansen M, Schmitt U, Lueddens H, Dannhardt G, Roesch F. Synthesis and evaluation of 5,7-dichloro-4-(3-{4-[4- (2-[18F]fluoroethyl)-piperazin-1-yl]-phenyl}-ureido)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid as a potential NMDA ligand to study glutamatergic neurotransmission in vivo, J Labelled Comp Radiopharm 2003 , 46(7):645-659

Abstracts (Posters and Talks)

Jansen M. (12/2010) Structure Function Studies of Cys Loop Receptors. Invited seminar, Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, USA.

Jansen M, Brahmamudi G. (2010) Mobility of channel lining transmembrane segments in muscle nACh receptors. Program No. 239.18. Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience.

Jansen M. (09/2010) Structure Function Studies of the Channel Lining M2 Transmembrane Segment in muscle nicotinic Acetylcholine Receptors. Invited seminar, Department of Physiology and Biophysics, Albert Einstein College of Medicine, New York, USA.

Nakashe P, Duddempudi PK, Blanton MP, Wiltfong RE, Jansen M.(2010) Structure and Function Studies of the Proton Coupled Folate Transporter. Presentation No. 2625-Pos. Abstract Viewer/Itinerary Planner. Bethesda, MD: Biophysical Society.

Brahmamudi G, Langsjoen D, D'Cunha RM, Jansen M.(2010) Highly Mobile Channel Lining Transmembrane Segments in Muscle Nicotinic Acetylcholine Receptors? Presentation No. 673-Pos. Abstract Viewer/Itinerary Planner. Bethesda, MD: Biophysical Society.

Wiltfong RE, Jansen M. (2009) Experimental Validation of Eukaryotic Cys Loop Receptor Homology Models: Torpedo vs GLIC/ELIC structures? Presentation No. L76-Pos. Abstract Viewer/Itinerary Planner. Bethesda, MD: Biophysical Society.

Jansen M. (2008) Heteromeric muscle nACh receptor channels function with a heptapeptide replacing the M3M4 loop. Program No. 530.6. Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience.

Bali M, Jansen M, Akabas MH. (2008) Disulfide cross link between alpha1 and beta2 subunit in alpha1beta2gamma2 GABA_A receptors at the propofol binding-site. Program No. 530.15. Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience.

McKinnon N, Jansen M, Akabas MH (2008) Size Matters! Functional constraints on the length and amino acid composition of the M3M4 loop of Cys-loop receptor ligand-gated ion channels. Program No. 530.1. Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience.

Wiltfong RE, Jansen M. (2008) Conformational changes of the nicotinic acetylcholine receptor M2M3 loop. P1.11. Neuropharmacology.

Jansen M, Bali M, Akabas MH. (2008) The dispensable Module: Cys Loop Receptors Lacking the Intracellular Domain. Gordon Research Conference - Ion Channels, Tilton, NH

Jansen M. (04/2008) Investigating the Structure and Function of Cys Loop Receptors. Invited seminar, Department of Physiology and Biophysics, Case School of Medicine, Case Western Reserve University, Cleveland, USA.

Jansen M. (02/2008) Investigating the Structure and Function of Cys Loop Receptors. Invited seminar, Department of Physiology and Biophysics, Miller School of Medicine, University of Miami, Miami, USA.

Jansen M. (01/2008) Structure and Function Studies of Cys Loop Receptors. Invited seminar, Department of Biological Sciences, University of Arkansas, Fayetteville, USA.

Jansen M. (01/2008) Structure and Function Studies of Cys Loop Receptors. Invited seminar, Department of Cell Physiology and Molecular Biophysics, TTUHSC, Lubbock, USA.

Jansen M, Bali M, Akabas MH. (2008) 5-HT3A and GABA rho1 Channels are Functional with a Heptapeptide in Place of the M3M4 Loop. Presentation No. 1323-Pos. Abstract Viewer/Itinerary Planner. Bethesda, MD: Biophysical Society.

Jansen M, Bali M, Reeves DC, Akabas MH. (2007) Functional 5-HT_3A and GABA rho1 channels obtained after replacement of the M3M4 loop by a heptapeptide. Program No. 441.9. Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience.

Bali M, Jansen M, Akabas MH. (2007) Spatial relationship between the GABAA receptor beta2 M3 region and the alpha1 subunit preM1 region. Program No. 441.8. Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience.

Qiu A, Jansen M, Sakaris A, Min SH, Chattopadhyay S, Tsai E, Sandoval C, Zhao R, Akabas MH, Goldman ID. (2007) The Molecular basis for hereditary folate malabsorption. Program No. 5868.2. Pediatric Blood and Cancer, 48 (6), 616-616. American Society of Pediatric Hematology/Oncology 20th Annual Meeting.

Jansen M, Akabas MH. (2005) The mating dance of the M2 and M3 transmembrane domains of the GABA_A receptor. Program No. 488.3. Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience.

Piel M, Hoehnemann S, Jansen M, Schmitt U, Dannhardt G, Roesch F. (2005) Synthesis, labelling and evaluation of a new fluorinated NMDA ligand to study glutamatergic neurotransmission in vivo. P01-12, Poster presentation, J. Label. Compd. radiopharm. 48, suppl. 1, 81.

Bauman A, Piel M, Hoehnemann S, Jennewein M, Jansen M, Krauss A, Schmitt U, Dannhardt G, Roesch F. (2005) Synthesis, labelling and evaluation of 4,6-dichloro-3-((3-(4-(2-fluorethoxy)phenyl) 2,4-dioxoimidazolidine)-1H-indole-2-carboxylic acid as radiotracer for imaging the NMDA-receptor status in vivo. P01-31, Poster presentation, J. Label. Compd. radiopharm. 48, suppl. 1, 100.

Bauman A, Piel M, Hoehnemann S, Jennewein M, Jansen M, Krauss A, Schmitt U, Dannhardt G, Roesch F. (2005) Synthesis, 18F-Labelling and evaluation of DDIC-1 for imaging the NMDA-receptor status in vivo. Annual scientific meeting of the German Pharmaceutical Society (DPHG), 05th -08th of Oct. 2005, Mainz, Germany, Abstract: DPhG Jahrestagung 2005, 104.

Jansen M, Rabe H, Dannhardt G, Lueddens H, Akabas MH. (2004) Defining the binding site for a new GABA_A receptor ligand. Program No. 51.10. Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience.

Reeves DC, Jansen M, Bali M, Akabas M. (2004) Functional effects of mutagenesis and chemical modification of a 5-HT3 receptor beta1-beta2 loop lysine residue. Program No. 626.8. Abstract Viewer/Itinerary Planner. Washington, DC: Society for Neuroscience.

Jansen M. (2003) Hydantoin-substituted 4,6-dichloroindole-2-carboxylic acids as ligands for the glycine binding site of the NMDA receptor with high affinity. Invited lecture at the Medicinal Chemistry Presentation at the Institute of Pharmacy, Mainz, Germany.

Jansen M, Rabe H, Dannhardt G, Lueddens H, Sinkkonen ST, Korpi E. (2003) Two novel GABA mimetics reveal functional discrimination on different GABA_A receptor subtypes. Program No. 824. Poster presentation at the 29th Goettingen Neurobiology Conference, Goettingen, Germany.

Piel M, Schirrmacher R, Hoehnemann S, Hamkens W, Jansen M, Schmitt U, Lueddens H, Dannhardt G, Roesch F. (2002) Synthesis and evaluation of fluorinated tetrahydroquinoline-2-carboxylic acid derivatives as potential NMDA ligands to study glutamatergic neurotransmission in vivo. Eur. J. Nucl. Med. 29, suppl. 1, 373.

Piel M, Schirrmacher R, Hoehnemann S, Hamkens W, Jansen M, Schmitt U, Lueddens H, Dannhardt G, Roesch F. (2002) Synthesis and evaluation of NMDA-antagonists at the strychnine-insensitive glycine binding site. Invited lecture at the PET Center Winter Lecture Series, 4th of Dec. 2002, Mainz, Germany.

Jansen M. (2002) Hydantoin-substituted 4,6-dichloroindole-2-carboxylic acids as high-affinity ligands of the glycine binding site of the NMDA receptor. Lecture at the annual scientific meeting of the German Pharmaceutical Society (DPHG), 09th -12th of Oct. 2002, Berlin, Germany.

Jansen M. (2002) Pharmacodynamic parameters in general and the "lunatic" GABA_A receptor in particular. Invited lecture at the seminar series "Molecular and cellular neurobiology", IAK-Neuro, Mainz, Germany.

Piel M, Schirrmacher R, Hoehnemann S, Hamkens W, Kohl B, Jansen M, Schmitt U, Lueddens H, Dannhardt G, Roesch F. (2002) 5,7-Dichloro-4-(3-{4-[4-(2-[18f]fluoroethyl)-piperazin-1-Yl]-phenyl}-ureido)-1,2,3,4-tetrahydroquinoline-2-carboxylic acid as a potential NMDA ligand to study glutamergic neurotransmission in vivo using PET. Poster at the annual scientific meeting of the German Pharmaceutical Society (DPHG), 09th -12th of Oct. 2002, Berlin, Germany.

Jansen M. (2002) Pharmacodynamic parameters (Kd, Ki, IC50, EC50). Invited lecture at the PET Center Summer Lecture Series, 8th of May 2002, Mainz, Germany.

Jansen M, Piel M, Kohl B, Schirrmacher R, Hoehnemann S, Hamkens W, Schmitt U, Lueddens H, Roesch F, Dannhardt G. (2002) Synthesis, pharmacological testing and 18F-fluorination of NMDA receptor ligands. Invited lecture at the PET-Symposium, 21st Sept. 2002, Mainz, Germany.

Dannhardt G, Jansen M. (2000) Design, synthesis and in-vitro evaluation of antagonists for the strychnine-insensitive glycine binding-site of the NMDA receptor. Poster presentation at the annual scientific meeting of the German Pharmaceutical Society (DPHG), 2000, Muenster, Germany.

Dannhardt G, Kohl B, Jansen M. (1998) Benzimidazoles as ligands for the strychnine-insensitive glycine site of the NMDA receptor. Poster presentation at the annual scientific meeting of the Austrian Pharmaceutical Society (OPhG), Graz, Austria.

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Jansen Laboratory - Publications

Abstracts (Posters and Talks)