Jose F. Perez-Zoghbi
Jose F. Perez-Zoghbi , PhD
Department of Cell Physiology and Molecular Biophysics
Texas Tech University Health Sciences Center
3601 4th Street, STOP 6551
Lubbock, Texas 79430
Phone: (806) 743-2522
FAX: (806) 743-1512
Emails: Jose.Perez-Zoghbi@ttuhsc.edu OR firstname.lastname@example.org
My laboratory is interested in understanding cellular mechanisms regulating smooth
muscle contraction of intrapulmonary airways and blood vessels.
For our research we use "living" lung slices prepared from animals in combination
with molecular, pharmacological, biochemical and imaging tools including high-speed
By studding simultaneously contraction and intracellular Ca2+ signaling in lung slices we demonstrated that the contraction of airways and arteries
is regulated by the frequency of intracellular Ca2+ oscillations occurring in their smooth muscle cells. Calcium independent pathways
involving the phosphorylation of a number of proteins are also important regulators
of smooth muscle contraction and are being studied in our laboratory.
We are currently exploring several models of airway and pulmonary vascular disease
to understand the mechanisms of increased airway and vascular smooth muscle contraction.
My teaching is focused on pulmonary physiology as well as basic mechanisms of cell
signaling and cytoskeleton dynamics.
Our research is important to understand basic cellular mechanisms underlying lung
diseases that affect smooth muscle contractility such as asthma, COPD (Chronic Obstructive
Pulmonary Disease), pulmonary hypertension and pulmonary edema.
Perez-Zoghbi, J.F.; Karner, C.; Ito, S.; Shepherd, M; Alrashdan, Y.; and Sanderson, MJ (2008): Ion
channel regulation of intracellular calcium and airway smooth muscle function. Pulm
Pharmacol Ther, 21: In press.
Perez-Zoghbi, J.F.; Mayora, A.; Ruiz, M-C. and Michelangeli, F. (2008): Heterogeneity of acid secretion
induced by carbachol and histamine along the gastric gland axis and its relationship
to [Ca2+]i. Am J Physiol Gastrointest Liver Physiol. 295:G671-81
Sanderson, M.J.; Delmotte, P, Bai, Y. and Perez-Zogbhi, J.F. (2007): Regulation of airway SMC contractility by Ca2+ signaling and sensitivity. Proc Am Thorac Soc. 5:23-31.
Perez-Zoghbi, J.F. and Sanderson, M.J. (2007): Endothelin-induced contraction of bronchiole and pulmonary
arteriole smooth muscle cells is mediated by intracellular Ca2+ oscillations. Am J Physiol Lung Cell Mol Physiol. 293: L1000-L1011
Perez, J.F. and Sanderson, M.J. (2005): The contraction of smooth muscle cells of intrapulmonary
arterioles is determined by the frequency of Ca2+ oscillations induced by 5-HT and KCl. J. Gen. Physiol. 125: 555-67
Perez, J.F. and Sanderson, M.J. (2005): The frequency of calcium oscillations induced by 5-HT,
ACH, and KCl determine the contraction of smooth muscle cells of intrapulmonary bronchioles.
J. Gen. Physiol. 125: 535-53
Perez, J.F.; Ruiz, M-C and Michelangeli, F. (2001): Simultaneous measurement and imaging of intracellular
Ca2+ and H+ transport in isolated rabbit gastric glands. J. Physiol. 537: 735-45
Perez, J.F.; Ruiz, M-C; Chemello M-E; Michelangeli, F. (1999): Characterization of a membrane
calcium pathway induced by rotavirus infection in culture cells. Journal of Virology 73: 2481-2490.
Perez, J.F.; Chemello, M.E.; Liprandi F; Ruiz, M-C.; Michelangeli, F. (1998): Oncosis in MA104
cells is induced by rotavirus infection through an increase in intracellular Ca2+ concentration. Virology 252: 17-27.
Check our Lab Page for positions available to students and post-docs
Last update: Feb-16-2009