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Perez-Zoghbi Lab







Welcome to our Lab Pages

Our Research Interests

  Our laboratory is interested in understanding cellular mechanisms regulating smooth muscle contraction of intrapulmonary airways and arteries.

  For our research we use  "living" lung slices prepared from animals in combination with molecular, pharmacological, and imaging tools including high-speed confocal microscopy.

  By studding simultaneously contraction and intracellular Ca2+ signaling in lung slices we demonstrated that the contraction of airways and arteries is regulated by the frequency of intracellular Ca2+ oscillations occurring in their smooth muscle cells.

  We are currently exploring the effects of inflammatory mediators associated with lung disease on the contractility and Ca2+ signaling of airway and arterial smooth muscle.

  Our research is important to understand basic cellular mechanisms underlying lung diseases affecting smooth muscle contractility such as asthma, COPD (Chronic Obstructive Pulmonary Disease), and pulmonary hypertension.

  Please follow the links bellow for more information...



   Research Link             

**Supplementary movies for R21 application**