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Perez-Zoghbi Lab

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Research Interests

Our laboratory is interested in understanding cellular mechanisms underlying lung diseases such as asthma, COPD (Chronic Obstructive Pulmonary Disease), and pulmonary hypertension by using "living" lung slices prepared from animals in combination with molecular, pharmacological and imaging tools including confocal microscopy. Currently, we are studying the mechanisms of regulation of intrapulmonary airway and artery smooth muscle contraction. We have found that the frequency of intracellular Ca2+ oscillations and the increase in Ca2+ sensitivity, stimulated by agonists, regulate the contraction of both intrapulmonary airways and arteries. We are also exploring the effects of inflammatory molecules associated with lung diseases on the contractility and Ca2+ signaling of airway and artery smooth muscle cells.

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Lab Personnel:
Jose F. Perez-Zoghbi, Ph.D., Assistant Professor, (PI)
Nilmini Wijeratne, Ph.D., Post Doctoral Research Assistant
Seema Mukherjee, Research Assistant
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Contact information:

Department of Cell Physiology
Texas Tech University Health Sciences Center
3601 4th Street, STOP 6551
Lubbock, Texas 79430
Phone: (806) 743-2522
FAX: (806) 743-1512
Email: Jose.Perez-Zoghbi@ttuhsc.edu

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