TTUHSC School of Medicine
Physiology

Cellular Physiology and Molecular Biophysics

R. Bryan Sutton

Associate Professor of Cell Physiology

Ph.D. in Biochemistry, The University of Texas Southwestern Medical Center, Dallas, Texas
Department of Cell Physiology
Texas Tech University Health Sciences Center
3601 4th Street, STOP 6551
Lubbock, Texas 79430
Phone: (806) 743-4058
FAX: (806) 743-1512
Email: Roger.B.Sutton.edu

Research Interests

Structural Biology of Neuronal Proteins; X-ray crystallography Development of new structure-based cytokines for cancer treatment

Published Papers

Articles in Peer-Reviewed Journals

Shaffer, J.B., Sutton, R.B., and Bewley, G.C.  Isolation of a cDNA Clone for Murine Catalase and Analysis of an Acatalasemic Mutant. J. Biol Chem. 262:12908–12911; 1987.

Sutton, R.B., Davletov, B.A., Berghuis, A.M., Südhof, T.C., and Sprang, S.R..  Structure of the First C2 domain of Synaptotagmin I: A novel Ca+2/ phospholipid-binding Fold. Cell. 80:929–938; 1995.

Rizo, J., Sutton, R.B., Breslau, J., Koerber, S.C., Porter, J., Hagler, A.T., Gierasch, L., and Rivier, J. (1996). A Novel Conformation in a Highly Potent, Constrained Gonadotrophin Releasing Hormone Antagonist. Journal of the American Chemical Society, 118(5):970–976; 1996.

Shao, X. Davletov, B.A., Sutton, R.B., Sudhof, T.C. and Rizo, J. Bipartite Ca+2-binding Motif in C2 domains of Synaptotagmin and Protein Kinase C. Science. 273:248–251; 1996.

Fasshauer, D.,  Sutton, R.B., Brunger, A.T., and Jahn, R..  Conserved structural features of the synaptic fusion complex: SNARE proteins reclassified as Q- and R- SNAREs.  Proceedings of the National Academy of Sciences USA, 95:15781-15786; 1998.

Sutton, R.B. and Sprang, S.R.  Structure of the Protein Kinase Cb phospholipid-binding C2 domain complexed with Ca2+.  Structure, 6(11):1395-1405; 1998.

Sutton, R.B., Fasshauer, D., Jahn, R., and Brunger, A.T.  Crystal Structure of a SNARE Complex involved in synaptic exocytosis at 2.4 Å Resolution.  Nature 395:347-353; 1998

Sutton, R.B., Ernst, J., and Brunger, A.T.  Crystal Structure of cytosolic C2A-C2B domains of synaptotagmin III.  Journal of Cell Biology, 147:589-598; 1999

Furst, H., Sutton, R.B., Brunger, A.T., Grigorieff, N.,  Three-Dimensional Structure of the AAA ATPase, NSF, at 11 Å resolution.  EMBO J 22 (17):4365-4374; 2003

Sieger, K.A., Mhashilkar, A.M., Stewart, A., Sutton, R.B., Strube, R.W., Chen, S-Y., Pataer, A., Swisher, S.G., Ramesh, R., Chada, S.  The tumor suppressor activity of MDA-7/IL-24 is mediated by intracellular protein expression in NSCLC cells.  Molecular Therapy 9(3), 355-367, 2004

Chada,S., Mhashilkar, A.M., Ramesh, R., Mumm, J.B., Sutton R.B., Bocangel, D., Zheng, M., Grimm, E.A. and Ekmekcioglu, S.,  Bystander activity of Ad-mda7: Human MDA-7 protein kills melanoma cells via an IL-20 receptor-dependent but STAT3-independent mechanism,  Molecular Therapy 10(6), 1085-1095, 2004.

Chada, S., Sutton, R.B., Ekmekcioglu, S., Ellerhorst, J., Mumm, J.B., Leitner, W.W., Yang, H.Y., Sahin, A.A., Hunt, K.K., Fuson, K.L., Poindexter, N., Roth, J.A., Ramesh, R., Grimm,E.A., Mhashilkar, A.M., MDA-7/IL-24 is a unique cytokine-tumor suppressor in the IL-10 family,  Int Immunopharmacol. 4(5), 649-667, 2004

Sutton, R.B., Navarro, J.,Gurevich, V.V., X-ray crystal structure of Ambystoma cone arrestin at 2.3 Å resolution. Journal of Molecular Biology, 354(5), 1069-80, 2005. (cover art).

Peng, B-H., Anderson, J., Lee, J.C., Sutton, R.B.*, Crystallization and preliminary X-ray diffraction of the ZO-binding domain of human occludin. Acta Cryst., F61, 2005

Montes, M, Fuson, KL., Sutton, RB*, and Robert, JJ.  Purification, crystallization and X-ray diffraction analysis of human synaptotagmin 1 C2A-C2B.Acta Cryst. , F62, p.926, 2006

Lagow, R.D., Bao, H., Cohen, E.N., Daniels, R.W., Zuzek, A., Williams, W.H., MacLeod, G.T., Sutton, R.B. and Zhang, B. Modification of a hydrophobic layer by a point mutation in Syntaxin 1A regulates the rate of synaptic vesicle fusion. PLoS Biology,5(4), e72, 2007

Fuson, KL, Montes, M, Robert, JJ, Sutton, RB*. Structure of human synaptotagmin 1 C2AB in the absence of Ca+2 reveals a novel domain association. Biochemistry, 46, 13041-13048, 2007.(cover art)

Greene, D., Garcia, T., Sutton, R.B., Gernert, K.M., Benian, G.M., Oberhauser, A.F., Single-molecule force spectroscopy reveals a stepwise unfolding of C. elegans giant protein kinase domains.  Biophysical Journal, Apr 4, 2008 (cover art)

Fuson, K.L., Sutton.R.B*. and Oberhauser, A.F., The C2 domains of human Synaptotagmin 1 have distinct mechanical properties. Biophysical Journal, 96, 1083-1090, 2009

Fuson, K.L., Zheng, M,

Fuson,K.L., Zheng, M, Patear, A. Rajagopal, R., Chada, S., Sutton, R.B.*, Structural mapping of post-translational modifications in human interleukin-24: The role of N-linked glycosylation and disulfide bonds in proper secretion and activity.  2009, JBC, in review 2009.

McDowell, CL, Sutton, R.B., OBermann, W.M.J., Expression of Hsp90 chaperone proteins in human tumor tissue. International Journal of Biological Macromolecules, 2009, accepted.