TTUHSC School of Medicine
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TTUHSC Surgery Burn Center of Research Excellence

Mission statement:

BCORE ultrasound

 

To be a Center for Excellence in Research covering the entire spectrum of burn injury, from microscopic alterations at the cellular level to the clinical care of the whole person to the impact of burn injuries on society. This includes injury prevention, disaster planning, initial response and resuscitation, critical care, pain control, infectious complications, nutrition, surgical management, wound care, psychosocial issues and long term rehabilitation. 

Goals:

To facilitate collaboration in basic science and clinical research across the disciplines of microbiology, biochemistry, medicine, surgery, nursing, physical therapy, psychology and occupational therapy, in order to:

  1. Increase the scientific knowledge related to burn injuries and resulting BCORE conference roomcomplications
  2. Develop new tools and strategies for the clinical care of acutely injured patients
  3. Describe epidemiologic characteristics of burn injuries
  4. Develop protocols for injury prevention and disaster/ mass casualty planning
  5. Investigate novel strategies in the management of acute and chronic wounds
  6. Create effective and integrated protocols for pain control, stress disorder, long term rehabilitation and transition to regular life post- burn injury

Objectives:

  1. Develop research collaborations between clinical and basic science departments within TTUHSC
  2. Develop research collaborations between TTUHSC and UMC
  3. Broaden the impact of our scientific work through publications, presentations at national meetings and collaborations with outside institutions involved in burn research

Faculty:

Director:

Sharmila Dissanaike MD

Core Faculty/ Advisory Board:

John Griswold, MD (Assistant Director), Kendra Rumbaugh, PhD, Abdul Hamood, PhD, Randy Wolcott, MD

Adjunct Faculty:

Ari Halldorsson, MD, Jenna Kesey, FNP, Lacy Phillips, RN, Wendi McNabb, RN

Key collaborating institutions:

BCORE lab


University Medical Center (UMC) Timothy J. Harnar Burn Center

 

Texas Tech University Health Sciences Center Clinical Research Institute (CRI),

 

UMC Trauma and Burn Services Department,

 

Research and Testing Laboratory,

 

Lubbock Wound Care Center

Background:

The topic of burns and wounds has been a fertile ground for research at TTUHSC for several years, with multiple peer reviewed publications and presentations at national and international meetings (Appendix A). The burn research program has also facilitated the involvement of TTUHSC faculty, residents, medical students and undergraduates in basic science and clinical research, providing the first research opportunity for many junior investigators. The designation as a TTUHSC Research Center of Excellence will serve to recognize these efforts both intra and extramurally, as well as develop the basic and clinical science infrastructure in order to be competitive for grant funding at both local and national levels. Formalization as a center will also facilitate access by students from all schools at TTUHSC as well as promote collaboration with outside organizations and individuals. Finally, a designated center of excellence will promote national recognition of the scientific work being done at TTUHSC and help recruit talented individuals interested in this area of research at all levels.

Burn care has historically been a multidisciplinary field from its inception as a separate specialty in the 1950s, with physicians, nurses, wound care technicians, physical therapists, occupational therapists and psychologists being recognized as equally important to the well-being of the burned patient. Perhaps in no other field of medicine is the concept of a team approach so firmly embedded. This is evident even at the national level with the American Burn Association (ABA) leadership comprised of representation from all specialties. This approach is well suited to translational research and collaboration, and is a likely factor in the high research productivity of the burn center despite a relatively small core physician faculty.

BCoRE Related Activities:

Dr. Sharmila Dissanaike

Grants and Research Funding

  • Principal Investigator, Laura W. Bush Institute for Women’s Health /UMC Women’s Health Research Scholar Grant “Gender Disparity in Burn Injury Survival”. 2013-2015, $20,000

Peer Reviewed Publications

  • Contamination of Unused, Nonsterile Gloves in the Critical Care Setting: A Comparison of Bacterial Glove Contamination in Medical, Surgical and Burn Intensive Care Units. Hall M, Trivedi U, Rumbaugh K, Dissanaike S*. Southwest Respiratory and Critical Care Chronicles, 2014 Jan 2(5)
  • Is automated electronic surveillance for healthcare associated infections accurate in the burn unit? Venable A, Long J, Dissanaike S*. J Burn Care Res. 2013 Nov-Dec;34(6):591-7
  • A protocol of early aggressive tube feeding increases ileus without perceptible benefit in severely burned patients. Kesey J, Dissanaike S*. J Burn Care Res. 2013 Sep-Oct;34(5):515-20
  • The association of pneumonia with clinical outcome in patients with inhalation injury. Dissanaike S*, Cox S, Arrieta S. Surgical Science, 2013 4(1):7-14 DOI: 10.4236/ss.2013.41002

Peer Reviewed Presentations/Published Abstracts:

  • Does the cost of air transfer and over-triage justify a modification in ABA transfer criteria? Kashefi N, Dissanaike S. North Texas Chapter of American College of Surgeons Meeting Dallas TX February 21st, 2014
  • Comparison of kaolin based hemostatic dressing to epinephrine in hemostasis in burn surgery. Puckett Y, Abdul-Hamed S, Dissanaike S. North Texas Chapter of American College of Surgeons Meeting Dallas TX February 21-22nd, 2014
  • Indocyanine green fluorescence as a non-invasive means to assess burn severity. Abdul-Hamed S, Griswold J, Dissanaike S. North Texas Chapter of American College of Surgeons Meeting Dallas TX February 21-22nd, 2014
  • The Effects of Vitamin C on Point-of-Care Glucose Monitoring. Sartor Z, Kesey J, Dissanaike S. American Burn Association Annual Meeting, Boston March 26th 2013
  • The Effects of Vitamin C on Point-of-Care Glucose Monitoring. Sartor Z, Kesey J, Dissanaike S. American Burn Association Annual Meeting, Boston March 26th 2013
  • Factors associated with poor outcome in necrotizing soft tissue infections. Levy B, Witt C, Dissanaike S. American Burn Association Annual Meeting, Palm Springs CA April 25th 2013
  • Nebulized Heparin – N Acetylcysteine does not improve outcomes in inhalation injury. Kashefi N, Dissanaike S. American Burn Association Annual Meeting, Palm Springs CA April 25th 2013 and North Texas Chapter of American College of Surgeons Meeting Dallas TX February 16th 2013
  • Complications of virtual reality for pain control in the burn population. Martin H, Dissanaike S. American Burn Association Annual Meeting, Palm Springs CA April 25th 2013
  • Infection Surveillance Techniques in the burn ICU. Venable A, Dissanaike S. American Burn Association Annual Meeting, Palm Springs CA April 25th 2013
  • Ileus as an outcome of aggressive nutrition in burn patients. Kesey J, Dissanaike S. Society for Critical Care Medicine Annual Meeting, Puerto Rico, January 23rd 2013 and American Burn Association Annual Meeting, Palm Springs CA April 25th 2013
  • Aggressive nutrition protocol using early initiation and high gastric residual volume in severely burned patients. Kesey J, Dissanaike S. Southern Region Burn Meeting, Norfolk VA November 16th 2012
  • The ups and downs of glycemic control in adult burn patients. Kesey J, Dissanaike S, Griswold JA. Southern Region Burn Meeting, Norfolk VA November 16th 2012
  • Complications of virtual reality for pain control in the burn population. Martin H, Dissanaike S. American Burn Association Annual Meeting, Palm Springs CA April 25th 2013
  • Infection Surveillance Techniques in the burn ICU. Venable A, Dissanaike S. American Burn Association Annual Meeting, Palm Springs CA April 25th 2013
  • Ileus as an outcome of aggressive nutrition in burn patients. Kesey J, Dissanaike S. Society for Critical Care Medicine Annual Meeting, Puerto Rico, January 23rd 2013 and American Burn Association Annual Meeting, Palm Springs CA April 25th 2013
  • Aggressive nutrition protocol using early initiation and high gastric residual volume in severely burned patients. Kesey J, Dissanaike S. Southern Region Burn Meeting, Norfolk VA November 16th 2012
  • The ups and downs of glycemic control in adult burn patients. Kesey J, Dissanaike S, Griswold JA. Southern Region Burn Meeting, Norfolk VA November 16th 2012

Invited Continuing Medical Education Presentations

  • Burn Professional: Pharmaceutical Industry Interaction – the Ethical Perspective. American Burn Association Annual Meeting, Boston MA March 28th 2014 
Dr. Abdul Hamood

Publications:

  • Kruczek C, Qaisar U, Colmer-Hamood JA, Hamood AN. 2013. Serum influences the expression of Pseudomonas aeruginosa quorum-sensing genes and QS-controlled virulence genes during early and late stages of growth. Microbiologyopen. doi: 10.1002/mbo3.147 (Epub ahead of print).
  • Kyle G. Miller, Phat L. Tran, Cecily L. Haley, Matt Myntti, Jane A. Colmer-Hamood, and Abdul N. Hamood. A Novel Agent That Inhibits Biofilm Development by Gram-positive and Gram-negative Wound Pathogens (submitted).

Grants:

  • CH Foundation: Abdul Hamood (PI), 01/01/2014-12/30/2014, Title: A Potential Therapy for Burn Wound Infections
Dr. John Griswold

Poster/Oral Presentations:

  • Coleman A, McGill T, Griswold J, Gard R, Holmes J: “Innovative Technique for Coverage of Neonatal Giant Abdominal Wall Defects.” American Pediatric Surgical Association, San Antonio, TX, May 20-23, 2012. (Poster)
  • Simoni J, Castillo JX, Simoni P, Moeller JF, Simoni G, Tomison MD, Campbell SJ, Griswold JA: “Effects of hemodilution with crystalloids and colloids on RBC vasodilatory signaling and oxygen affinity.” American Society for Artificial Internal Organs (ASAIO), San Francisco, CA, June 14-16, 2012
  • Vugrin M, Field DK, Edwards P, Gassett C, Shippey S, Griswold J, Dentino A: “Collaborative Efforts in Information Literacy - The Library and Clinical Clerkships: Surgery, Internal Medicine and Geriatrics.” Association of American Medical Colleges (AAMC), San Francisco, CA, November 2-7, 2012 (Poster)
  • Kesey J, Dissanaike SD, Griswold JA: “The Ups and Downs of Glycemic Control in Adult Burn Patients.” Southern Region burn Conference, Norfolk, VA, November 16-18, 2012

Publications:

  • Griswold J: Why Diabetic Wounds Do Not Heal. Texas Heart Institute Journal. 39 (6): 860-861, 2012
  • Watters C, Deleon K, Trivedi U, Griswold JA, Lyte M, Hampel KJ, Wargo MJ, Rumbaugh KP: Pseudomonas aeruginosa biofilms perturb wound resolution and antibiotic tolerance in diabetic mice. Medical Microbiology and Immunology. 202:131-141, 2013

Chapters/Books:

  • Schmitz B, Griswold JA: “Airway Management in Burn Patients”, Airway Management. Benumof & Hagberg 3rd edition. 2013, 44: pp 902-909

Invited Lectures:

  • Trauma Symposium - Midland, TX, 2012. “Intensive Insulin Therapy”
  • ABA presentation - Seattle, WA, 2012. “Utilization of Molecular Sequencing Methods to Characterize the Microflora of Burn Wounds During Initial Hospital Admission”
  • Austin Trauma & Critical Care Conf - Austin, TX, 2012. “American College of Surgeons Trauma Quality Improvement Program (TQIP)”
  • Austin Trauma & Critical Care Conf - Austin, TX, 2012. “Escharotomy: when & how?
  • DeBakey-Cooley Symposium - Austin, TX, 2012. “Oil Exploration & Why Diabetic Wounds Do Not Heal: It’s Not Just Blood Supply!
Dr. Kendra Rumbaugh

Publications:

  • Watters C, Everett JA, Haley C, Clinton A, Rumbaugh KP. Insulin Treatment Modulates the Host Immune System To Enhance Pseudomonas aeruginosa Wound Biofilms. Infect Immun. 2014 Jan;82(1):92-100.
  • Filiatrault MJ, Tombline G, Wagner VE, Van Alst N, Rumbaugh K, Sokol P, Schwingel J, Iglewski BH. 2013. Pseudomonas aeruginosa PA1006, Which Plays a Role in Molybdenum Homeostasis, Is Required for Nitrate Utilization, Biofilm Formation, and Virulence. PLoS One.8(2):e55594. doi: 10.1371/journal.pone.0055594. Epub 2013 Feb 8. PMID:23409004
  • A. Korgaonkar , U. Trivedi , K.P. Rumbaugh , M. Whiteley. 2013. Community surveillance enhances P. aeruginosa virulence during polymicrobial infection. Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):1059-64. PMID:23277552
  • Watters C., Deleon K., Trivedi U., Griswold J.A., Lyte M., Hampel K.J., Wargo M.J., Rumbaugh K.P. 2013. Pseudomonas aeruginosa biofilms perturb wound resolution and antibiotic tolerance in diabetic mice. Med Med Microbiol Immunol. 2013 Apr;202(2):131-41. (recommended by F1000)

Presentations:

  • 2013 14th International Conference on Pseudomonas (Lausanne, Switzerland). Profiling Pseudomonas aeruginosa wound infections with high-throughput genomic methods. K.H. Turner, U. Trivedi, K. Rumbaugh and M. Whiteley. Selected for Oral Presentation
  • 2013 American Society for Microbiology (New Orleans, LA). Chemotaxis contributes to Pseudomonas aeruginosa virulence in a thermally injured mouse model of infection. J Everett, K Turner, M Whitely, and K Rumbaugh. Samuel Kaplan Award (1stplace poster presentation)
  • 2013 American Society for Microbiology (New Orleans, LA). The Effects of Albumin on Pseudomonas aeruginosa Quorum Sensing in the Chronic Wound Environment. A Clinton, J Chavez, Y Mechref, K Rumbaugh. Samuel Kaplan Award (2nd place poster presentation)
  • 2013 American Society for Microbiology (New Orleans, LA). Antibiotic Resistance in Diabetic and Non-Diabetic Wounds. U Trivedi, S Parameswaran, A Armstrong, S Dissanaike and K Rumbaugh . Poster presentation
  • 2013 American Society for Microbiology (New Orleans, LA). The Role of Clostridium perfringens in Multi-Species Wound Biofilms. H Sparks, S DeLeon, A Clinton and K Rumbaugh. Poster presentation
  • 2013 American College of Surgeons (Washington, DC) and American Society for Microbiology (New Orleans, LA). α-Amylase Inhibits Staphylococcus aureus Biofilms. D Fleming, U Trivedi and K Rumbaugh. Poster presentation
  • 2013 American Society for Microbiology (New Orleans, LA). Pseudomonas aeruginosa quorum sensing in chronic wound infections. AR Cueva, A Armstrong, J Everett, D Fleming, K Turner, M Whiteley and K Rumbaugh. Poster presentation
  • 2013 American Society for Microbiology (New Braunsfels, TX). Is quorum sensing involved in the pathogenesis of Pseudomonas aeruginosa in chronic wound infections? Armstrong A., Haley C., Chavez J., Mechref Y., KP Rumbaugh. Poster presentation, Orville Wyss Award for Medical Microbiology, First Place.
  • 2013 American Society for Microbiology (New Braunsfels, TX). α-Amylase Inhibits Staphylococcus aureus Biofilms. Fleming D., Trivedi U., K.P Rumbaugh. Poster presentation, Orville Wyss Award for Medical Microbiology, Honorable Mention.
  • 2013 American Society for Microbiology (New Braunsfels, TX). Insulin treatment modifies the mammalian immune response to enhance Pseudomonas aeruginosa wound biofilms. Watters, C., Haley, C., Clinton, A., Rumbaugh, K. P. Charlie Gauntt Award, 2nd place for outstanding oral presentation.
  • 2013 American Society for Microbiology (New Braunsfels, TX). Inhibition of quorum sensing in a wound-like environment prevents Pseudomonas aeruginosa from killing Staphylococcus aureus. Clinton A., DeLeon S., Chavez J., Mechref Y., KP Rumbaugh. Poster presentation
  • 2013 American Society for Microbiology (New Braunsfels, TX). Pseudomonas aeruginosa chemotaxis towards serum in a thermally injured mouse model of infection. Everett J. and KP Rumbaugh. Poster presentation
  • 2013 American Society for Microbiology (New Braunsfels, TX). Interactions of Pseudomonas aeruginosa and Staphylococcus aureus in dual-species wound biofilms. DeLeon S., Fowler H., Clinton A., KP Rumbaugh. Poster presentation
  • 2013 TTUHSC Student Research Day. Serum Albumin Influences Quorum Sensing in Pseudomonas aeruginosa. Jamerson J., Clinton A., Rumbaugh, K. P. Poster presentation, won 1st place for junior medical student competition
  • 2013 TTUHSC Student Research Day. Utilization of Molecular Sequencing Methods to Characterize the Microflora of Burn Wounds During Initial Hospital Admission. Parameswaran S., Trivedi U., Rumbaugh K., Dowd S., Vega D., Wolcott R., Dissanaike S., Griswold G. Poster presentation
  • 2013 CHD Bioscience, Fort Collins, CO. “Treatments for Common Wounds.” Invited seminar

Grants:

Extramural awards funded

  • Laura W. Bush Institute for Women’s Health (Rumbaugh, Co-PI) 2013-1015 $20,000 “Gender Disparity in Burn Injury Survival”
  • Army Research Office (Rumbaugh, Sub-contract PI; Whiteley, PI) 2013-2017 $194,981 (total subcontract) “Polymicrobial virulence mechanisms in chronic wounds”
  • CHD Bioscience (Rumbaugh, PI) 2013-2014 $15,100 “Preclinical effiacy study of Veriox to treat chronic wound infections”

Grants submitted and pending approval

  • NIH/NIAID R15 (Rumbaugh, PI) $448,435 “Pseudomonas aeruginosa and Staphylococcus aureus Interspecies Interactions in Wounds”
  • NIH/NIAID R21 (Rumbaugh, Subcontract-PI) $188,586 (total subcontract) “Genetic determinants of bacterial fitness in polymicrobial wound infections”  

Grants submitted but not funded

  • NIH/NIAID STTR (Rumbaugh, Sub-contract PI; Kaufmann, PI) $305,529 (total subcontract) “Recombinant Human Anti-Pseudomonas Polyclonal Antibodies As Anti-Infectives”
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