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Profile for Thomas Thekkumkara, PHD

Thomas Thekkumkara

Thomas Thekkumkara, PHD

  • Regional Dean
  • Professor (Tenured)
  • Visiting Professor
  • Professor
  • Regional Dean
Office Phone: 806-356-4028
Email: Thomas.Thekkumkara@ttuhsc.edu
Mail Address: 1300 S Coulter St
Amarillo TX 79106-1712

Research Interests

I am primarily interested in molecular mechanisms of activation and regulation of G-protein coupled receptors. I have focused on the receptor for the potent hormone; angiotensin II as a model for the subfamily of G-protein coupled receptors, which bind peptide ligands. Angiotensin II is the effector of the renin-angiotensin system, which plays a critical role in blood pressure regulation and electrolyte balance and which has been implicated in many important medical disorders, including hypertension and diabetes with its associated cardiovascular and renal damage. Consequently, investigating the biochemical and molecular mechanisms of Angiotensin II receptor activation and regulation is crucial for understanding the physiology and pathophysiology of the renin-angiotensin system.

Selected Publications:

  • Pillai VC, Snyder RO, Gumaste U, Thekkumkara TJ, Mehvar R. Effects of Transient Overexpression or Knockdown of Cytochrome P450 Reductase on Reactive Oxygen Species Generation and Hypoxia-Reoxygenation Injury in Liver Cells.. Clin. Exp. Pharmacol. Physiol.. 2011;38:846-853.
  • Koganti S, Thekkumkara TJ. 2-Methoxy Estradiol Mediated Downregulation of Angiotensin Type 1 Receptor Expression.. FASEB J.. 2010;24:786.13.
  • Snyder R, Thekkumkara TJ. A Novel Mechanism for 13-cis Retinoic Acid mediated Angiotensin Type 1 Receptor Downregulation.. FASEB J.. 2010;24:702.1.
  • Pillai VC, Yesudas R, Shaik IH, Thekkumkara TJ, Bickel U, Srivenugopal KS, Mehvar R. Delivery of NADPH-cytochrome P450 reductase antisense oligos using avidin-biotin approach. Bioconjug Chem. 2010;21:203-207.
  • Vemula S, Roder KR, Yang T, Bhat GJ, Thekkumkara TJ, Abbruscato TJ. Functional role for sodium dependent glucose transport across the blood-brain barrier during oxygen glucose deprivation.. J. Pharmacol. Exp. Ther.. 2009;(328(2)):487-95.
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