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Profile for Quentin Smith, PhD

Quentin Smith

Quentin Smith, PhD

  • Dean
  • Senior Associate Dean for Sciences
  • Dean
  • Senior Associate Dean
  • Committee Member
Office Phone: 806-414-9277
Email: Quentin.Smith@ttuhsc.edu
Mail Address: 1300 S Coulter St
Amarillo TX 79106-1712

Biography

Quentin Smith’s primary research interests are focused on assessing and ultimately improving drug delivery across the blood-brain barrier for the treatment of brain tumors, stroke, and neurodegenerative disease. He has established highly sensitive, regio-specific methods to map the distribution of low levels of bound and free drug in brain and brain metastases of breast cancer following systemic drug administration in animals. His lab is dissecting the roles of key BBB transporters in controlling brain and brain metastasis exposure of drugs. Also, he is working on developing and evaluating modified drugs that are specifically designed to circumvent the BBB. Both novel carrier vectors to deliver conventional drugs and rational design of drug modifications that retain chemotherapeutic activity while circumventing the transporters that limit brain access are being investigated. Research is funded by the Cancer Prevention Research Incentive of Texas (CPRIT), DoD, NIH, and numerous collaborations with industry.

Research Interests

Blood Brain Barrier, Drug Transport, Cancer Chemotherapy

Selected Publications:

  • Rajendar MK, Liu X, Adkins CE, Smith QR, Lockman PR. Paclitaxel-Hyaluronic Nano-Conjugates Prolong Overall Survival in a Preclinical Brain Metastases of Breast Cancer Model. Molecular Cancer Therapeutics. 2013.
  • Kalvass JC, Smith QR, Kim BL. Why clinical modulation of efflux transport at the human blood-brain barrier is unlikely: the ITC evidence-based position.. CLin Pharmacol Ther. 2013;94(1):80-94.
  • Adkins CE, Smith QR, Lockman PR. “Permeability Characteristics of Triple-Negative Breast Cancer Brain Metastases Over Time”. Annual Meeting of the American Association of Pharmaceutical Scientists. 2012.
  • Naik P, Smith QR, Cucullo L. Protective Role Of Antioxidant Supplementation In Tobacco Smoke Toxicity At The Blood-Brain Barrier. Experimental biology 2012. .
  • Smith QR. Brain metastases as preventive and therapeutic targets. Nature Revews Cancer. 2011;11(5):352-363.
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