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Profile for Richard Leff

Richard Leff

Richard Leff

  • Professor & Sr. Associate Dean for Clinical/Translational Research
  • Managing Partner & Chief Scientific Officer
  • Adjunct Professor of Pathology
Office Phone: 214-654-9404 ext 226
Mail Address: 5920 Forest Park Rd Ste 400
Dallas TX 75235-6418


RICHARD D. LEFF, PHARM.D., FCCP: Dr. Leff was born and raised in a rural town in northern Illinois. He received a Bachelor of Science in Education from Northern Illinois University, Bachelor of Science in Pharmacy from Creighton University, and Doctor of Pharmacy from the University of Minnesota in 1975. He completed a postdoctoral fellowship in pediatric pharmacology at the University of Iowa and has served on the faculties of the University of Texas at Austin, University of Iowa, and University of Kansas. In 1997, he assumed the position of Vice President, Clinical Services and Research, Child Health Corporation of America and in 2000, he assumed the position of Director, Pharmaceutical Product Development at the Midwest Research Institute. He also founded Pediatric Research Associates, LLC, a consulting group formed to address issues related to the Pediatric Research Equity Act. Currently, he is Professor and Sr. Associate Dean for Clinical/Translational Research at Texas Tech University Health Sciences Center School of Pharmacy and Founding Director of the Clinical Pharmacology & Experimental Therapeutics Center, a designated Center for Research Excellence at the School of Pharmacy. In 2012, he was awarded the James A. ‘Buddy’ Davidson Endowed Professorship in Pediatric Pharmacology. He has over 150 publications and has been invited to deliver over 250 presentations. He is internationally recognized for his experience with drug and medical device development in infants and children. Current research funding includes the Cancer Prevention and Research Institute of Texas (CPRIT) and the NIH Clinical and Translational Science Award (CTSA). As Sr. Associate Dean, Dr. Leff is responsible for strengthening the clinical research infrastructure among the regional campuses and promoting institutional collaborations to facilitate faculty scholarship.

Research Interests

Pediatric Clinical Pharmacology & Therapeutics
- drug efficacy and toxicity in infants and children
- drug delivery systems
- pharmacokinetic studies in infants and children

Pediatric Pharmaceutical Product & Medical Device Development

Dry Blood Spot (DBS) Analyses for Drug Development

Selected Publications:

  • Hall RG, Swancutt M, Meek CC, Leff RD, Gumbo T. Ethambutol pharmacokinetic variability is linked to body mass in overweight, obese, and extremely obese people. Antimicrob Agents Chemother 2012;56(3):1502-1507.
  • Srivastava SK, Pasipanodya J, Meek CC, Leff RD, Gumbo T. Editor’s Choice: Multi-drug resistant does not arise due to non-compliance but between-patient pharmacokinetic variability.. J Inf Dis. 2011;(204(12):):1951-9.
  • Srivastava SK, Sherman C, Meek CC, Leff RD, Gumbo T. Pharmacokinetic mismatch does not lead to emergence of isoniazid or rifampin-resistant Mycobacterium tuberculosis, but better microbial effect: A new paradigm for anti-tuberculosis scheduling.. Antimicrob Agents Chemother 2011;(55:):5085-9.
  • Greer LG, Leff RD, Rogers VL, Roberts SW, McCracken GH, Wendel GD, Sheffield JS. Pharmacokinetics of Oseltamivir According to Trimester of Pregnancy. Amer J Ob Gyn. 2011;(204 (6) ):S89-93.
  • Greer LG, Leff RD, Rogers VL, Roberts SW, McCracken GH, Wendel GD, Sheffield JS. Pharmacokinetics of Oseltamivir in Breast Milk and Maternal Plasma.. Amer J Ob Gyn 2011;(204 (6):):524.e1-4.