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Profile for Tom Abbruscato, Ph.D.

Tom Abbruscato

Tom Abbruscato, Ph.D.

  • Professor and Chair of Pharmaceutical Sciences
  • Associate Dean of the Graduate School of Biomedical Sciences
  • Chair of Pharmaceutical Sciences
  • Associate Dean of Graduate School of Biomedical Sciences
Office Phone: 806-414-9234
Email: Thomas.Abbruscato@ttuhsc.edu
Mail Address: 1300 S Coulter St
Amarillo TX 79106-1712

Biography

The research of Dr. Abbruscato's Lab includes approaches to understand the mechanisms by which the neurovascular unit responds to brain ischemia with respect to transport protein expression, cell-cell interactions, and the transport of drugs, ions and nutrients that are vital for brain recovery after stroke. We utilize a variety of in vitro blood-brain barrier models to both measure drug and nutrient uptake/transport and to characterize the mechanisms involved in the maintenance of the paracellular barrier during pathophysiologic states. The overall goal of our lab is to make significant preclinical discoveries that will translate clinically to novel treatment options for stroke patients, which unfortunately to this date do not have many viable therapeutic options to improve brain recovery after stroke.

Research Interests

blood-brain barrier, stroke, diabetes, sodium glucose transport, opioid receptors and stroke neuroprotection, brain drug transport

Selected Publications:

  • Yang L, Shah K, Abbruscato TJ. “Astrocyte regulation of brain endothelial cell barrier properties”. 2012;814(Part 4):451-466.
  • Shah K, Yang L, Abbruscato TJ. “In vitro models of the blood-brain barrier. 2012;814(Part 4):431-449.
  • Yang L, Shah K, Wang H, Karamyan VT, Abbruscato TJ. Characteriztion of the effects of biphalin, an opioid receptor agonist, in a model of focal brain ischemia.. J. Pharmacol. Exp. Ther.. 2011;(339(2)):499-508.
  • Paulson JR, Yang T, Selvaraj PK, Mdzinarishvili A, Van der Schyf AC, Klein J, Bickel U, Abbruscato TJ. Nicotine Exacerbates Brain Edema during in vitro and in vivo Focal Ischemic Conditions.. J. Pharmacol. Exp. Ther.. 2010;(332(2):):371-379.
  • Alfonso LF, Srivenugopal KS, Arumugam TV, Abbruscato TJ, Weidanz JA, Bhat GJ. Aspirin inhibits camptothecin-induced p21CIP1 levels and potentiates apoptosis in human breast cancer cells.. Int J Oncol.. 2009;(34(3)):597-608.
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