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Profile for Vardan Karamyan, PhD

Vardan Karamyan

Vardan Karamyan, PhD

  • Assistant Professor Pharmaceutical Sci Amarillo
Office Phone: 806-356-4015 ext 286
Email: vardan.karamyan@ttuhsc.edu
Mail Address: 1300 S Coulter St
Amarillo TX 79106-1712

Biography

Dr. Karamyan joined the Department of Pharmaceutical Sciences in August 2008. He received his Doctor of Pharmacy (Magna cum laude) from the Faculty of Pharmacy, Yerevan State Medical University, Armenia, and Ph.D. in Biology from the Institute of Biochemistry, National Academy of Sciences, Yerevan, Armenia. He continued his postdoctoral training in the laboratory of Dr. Robert C. Speth at the Department of Pharmacology in the School of Pharmacy, University of Mississippi.

Research Interests

Our group is studying the (patho)physiological function of metalloendopeptidase neurolysin (EC 3.4.24.16) in ischemic stroke and neurogenic hypertension.


Additionally, in collaboration with Dr. Thomas Abbruscato we study the role of opioid receptors for neuroprotection in stroke. This project involves (patho)physiological and pharmacological studies to understand alterations of opioid receptors in pathophysiology of stroke, and development of new opioid ligands (in collaboration with medicinal chemists) to target these receptors.

Selected Publications:

  • Yang L, Islam MR, Karamyan VT, Abbruscato TJ. In vitro and in vivo efficacy of a potent opioid receptor agonist, biphalin, compared to subtype-selective opioid receptor agonists for stroke treatment.. Brain Research 2015;1609:1-11.
  • Koganti S, Snyder R, Gumaste U, Karamyan VT, Thekkumkara TJ. 2-methoxyestradiol binding of GPR30 down-regulates angiotensin AT(1) receptor.. Eur J Pharmacol 2014;723:131-40.
  • Speth RC, Eduardo CJ, C. B, A. L, L. G, J. SD, K. SL, Ines S, Michael B, Karamyan VT. Distribution of non-AT1, non-AT2 binding of 125I-sarcosine1, isoleucine8 angiotensin II in neurolysin knockout mouse brains. PlosOne 2014;9(8):e105762.
  • Rashid M, Wangler NJ, Yang L, Shah K, Arumugam TV, Abbruscao TJ, Karamyan VT. Functional upregulation of endopeptidase neurolysin during post-acute and early recovery phases of experimental stroke in mouse brain. J Neurochemistry 2014;129(1):179-89.
  • Wangler NJ, Santos KL, Schadock I, Hagen FK, Escher E, Bader M, Speth RC, Karamyan VT. Identification of membrane-bound variant of metalloendopeptidase neurolysin (EC 3.4.24.16) as the non-angiotensin type 1 (non-AT1), non-AT2 angiotensin binding site. J Biol Chem 2012;287(1):114-22.
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