||Maciej Markiewski, M.D., Ph.D.
||Dr. Markiewski joined the School of Pharmacy in Abilene as an Associate Professor in the fall of 2010. He is a physician scientist with an interest and background in the biology of innate immunity, tumor immunology and the tumor microenvironment. Dr. Markiewski came to TTUHSC from the University of Pennsylvania, where he was a Senior Research Investigator in the Department of Pathology and Laboratory Medicine after he finished his postdoctoral training there. Prior to his postdoctoral position at the University of Pennsylvania, he received training in surgical pathology and cytopathology and served as a pathologist at several health centers in Poland.
• M.D. Medicine, Pomeranian Medical University (Szczecin, Poland), 1984-90
• Ph.D. Pathology, Pomeranian Medical University (Szczecin, Poland), 1990-95
• PDF Immunology, University of Pennsylvania (Philadelphia, PA), 2001-06
The research performed in the Markiewski laboratory focuses on the role of innate immunity, including complement and inflammation, in the growth of normal and malignant tissue. Its long-term goal is to elucidate and understand the role of complement in the development of primary and metastatic tumors. Importantly, these studies explore the possibility that the inhibition of complement can be used as a novel form of anti-cancer immunotherapy.
Jain R, Rawat A, Verma B, Markiewski MM and Weidanz JA. (2012). Antitumor activity of a monoclonal antibody targeting MHC class I–Her2 peptide complexes. (Accepted) Journal of National Cancer Institute.
Verma B, Jain R, Casteltine S, Rennels A, Bhattacharya R, Markiewski MM, Rawat A, Neethling F, Bickel U, Weidanz JA. TCR mimic monoclonal antibodies induce apoptosis of tumor cells via immune effector-independent mechanisms. J Immunol. 2011 Mar 1; 186(5): 3265-76
Strey CW, Marquez-Pinilla RM, Markiewski MM, Siegmund B, Oppermann E, Lambris JD, Bechstein WO. Early post-operative measurements of cytokine plasma levels combined with pre-operative bilirubin levels identify high-risk patients after liver resection. Int J Mol med. 2011 Mar; 27(3): 447-54
Nigrovic PA, Malbec O, Lu B, Markiewski MM, Kepley C, Gerard N, Gerard C, Daeron M, Lee DM. C5a receptor enables participation of mast cells in immune complex arthritis independently of Fc gamma receptor modulation. Arthritis Rheum. 2010 Nov; 62(11): 3322-33
Markiewski MM, Kourtzelis I, Doumas M, Rafail S, Kambas K, Mitroulis I, Panagoutsos S, Passadakis P, Vargemezis V, Magotti P, Qu H, Mollnes TE, Ritis K, Lambris JD. Complement anaphylatoxin C5a contributes to hemodialysis-associated thrombosis. Blood, 2010 Jul 29; 116(4):631-9
Markiewski MM, Lambris JD. Unwelcome complement. Cancer Res. 2009 Aug 15; 69(16):6367-70
Markiewski MM, Hill-Baskin AE, Buchner DA, Shao H, DeSantias D, Subramaniam S, Berger NA, Croniger C, Lambris JD, Nadeau JH. Diet-induced hepatocellular carcinoma in genetically-predisposed mice.
Hum Mol Genet. 2009 Aug 15; 18(16):2975-88
Markiewski MM, DeAngelis RA, Strey CW, Foukas P, Gerard C, Gerard N, Lambris JD. The regulation of liver cell survival by complement. J Immunol. 2009 May 1; 182(9):5412-8
Markiewski MM, Lambris JD. Is complement good or bad for cancer patients? A new perspective on an old dilemma. Trends Immunol. 2009 Jun; 30(6):286-92
Markiewski MM, DeAngelis RA, Lambris JD. Complexity of complement activation is sepsis.
J Cell Mol Med. 2008 Dec;12(6A):2245-54.
Ricklin D, Ricklin-Lichtsteiner SK, Markiewski MM, Geisbrecht BV, Lambris JD. Cutting edge: members of the Staphylococcus aureus extracellular fibrinogen-binding protein family inhibit the interaction of C3d with complement receptor 2. J Immunol. 2008 Dec 1; 181(11):7463-7.
Markiewski MM, DeAngelis RA, Benencia F, Ricklin-Lichtsteiner SK, Koutoulaki A, Gerard C, Coukos G, Lambris JD. Modulation of the antitumor immune response by complement. Nat Immunol. 2008 Nov;9(11):1225-35.
Markiewski MM, Kambas K, Pneumatikos IA, Rafail SS, Theodoru V, Konstantonis D, Kourtzelis I, Doumas MN, Magotti P, DeAngelis RA, Lambris JD, Ritis KD. C5a and TNF-alpha up-regulate the expression of tissue factor in intra-alveolar neutrophils of patients with the acute respiratory distress syndrome. J Immunol. 2008 Jun 1; 180(11):7368-75.
Markiewski MM, lambris JD. The role of complement in inflammatory diseases from behind the scenes into the spotlight. Am J Pathol. 2007 Sep; 171(3):715-27.
Markiewski MM, Nilsson B, Ekdahl KN, Mollnes TE, Lambris JD. Complement and coagulation: strangers or partners in crime? Trends Immunol. 2007 Apr; 28(4):184-92.
Markiewski M.M., DeAngelis R.A., Lambris J.D. Liver regeneration – A link to inflammation through complement. Curr Topics Complement, Adv Exp Med Biol. 2006;586:17-34.
Markiewski MM, DeAngelis RA, Lambris JD. Liver inflammation and regeneration: Two distinct biological phenomena or parallel pathophysiologic processes? Mol Immunol. 2006 Jan;43(1-2):45-56.
DeAngelis RA, Markiewski MM, Taub R, Lambris JD. A high-fat diet impairs liver regeneration in C57BL/6 mice through overexpression of the NF-kappaB inhibitor, IkappaBalpha. Hepatology, 2005 Nov;42(5):1148-1157.
Strey CW, Winters M, Markiewski MM, Lambris JD. Partial hepatectomy induced liver proteome changes in mice. Proteomics, 2005 Jan; 5 (1):318-25
Markiewski MM, Mastellos D, Tudoran R, DeAngelis RA, Strey CW, Franchini S, Wetsel RA, Erdei A, Lambris JD. C3a and C3b Activation Products of the Third Component of Complement (C3) Are Critical for Normal Liver Recovery after Toxic Injury. J Immunol. 2004 Jul 15;173(2):747-754.
Mastellos D, Prechl J, Laszlo G, Papp K, Olah E, Argyropoulos E, Franchini S, Tudoran R, Markiewski M, Lambris JD, Erdei A. Novel monoclonal antibodies against mouse C3 interfering with complement activation: description of fine specificity and applications to various immunoassays. Mol Immunol. 2004 Mar;40(16):1213-21.
Markiewski M, Strey CW, Mastellos D, Tudoran R, Spruce LA, Greenbaum LE, Lambris JD. The proinflammatory mediators C3a and C5a are essential for liver regeneration. J Exp Med. 2003 Sep 15;198(6):913-23.
Brzosko I, Brzosko M, Fiedorowicz-Fabrycy I, Prajs K, Cyrylowski L, Markiewski M. Psychical disturbances in a patient with pseudoxanthoma elasticum. Case Rep Clin Pract Rev, 2003; 4(1): 34-37.
Riedemann NC, Guo RF, Neff TA, Laudes IJ, Keller KA, Sarma VJ, Markiewski M, Mastellos D, Strey CW, Pierson CL, Lambris JD, Zetoune FS, Ward PA. Increased C5a receptor expression in sepsis. J Clin Invest. 2002 Jul;110(1):101-8.
Machalinski B, Kijowski J, Marlicz W, Gontarewicz A, Markiewski M, Paczkowski M, Kopkowski A, Majka M, Ostrowski M, Ratajczak MZ. Heparinized cadaveric organ donors (HCOD)--a potential source of hematopoietic cells for transplantation and gene therapy. Transplantation. 2001 Apr 15;71(7):1003-7.
Zapolska-Downar D, Zapolski-Downar A, Markiewski M, Ciechanowicz A, Kaczmarczyk M, Naruszewicz M. Selective inhibition by probucol of vascular cell adhesion molecule-1 (VCAM-1) expression in human vascular endothelial cells. Atherosclerosis. 2001 Mar;155(1):123-30.
Zapolska-Downar D, Naruszewicz M, Zapolski-Downar A, Markiewski M, Bukowska H, Millo B. Ibuprofen inhibits adhesiveness of monocytes to endothelium and reduces cellular oxidative stress in smokers and non-smokers. Eur J Clin Invest. 2000 Nov;30(11):1002-10.
Zapolska-Downar D, Zapolski-Downar A, Markiewski M, Ciechanowicz A, Kaczmarczyk M, Naruszewicz M. Selective inhibition by alpha-tocopherol of vascular cell adhesion molecule-1 expression in human vascular endothelial cells. Biochem Biophys Res Commun. 2000 Aug 11;274(3):609-15.
Domagala W, Markiewski M, Harezga B, Dukowicz A, Osborn M. Prognostic significance of tumor cell proliferation rate as determined by the MIB-1 antibody in breast carcinoma: its relationship with vimentin and p53 protein. Clin Cancer Res. 1996 Jan;2(1):147-54.
Hadaczek P, Siprashvili Z, Markiewski M, Domagala W, Druck T, McCue PA, Pekarsky Y, Ohta M, Huebner K, Lubinski J. Absence or reduction of Fhit expression in most clear cell renal carcinomas. Cancer Res. 1998 Jul 15;58(14):2946-51.
Starzynska T, Markiewski M, Domagala W, Marlicz K, Mietkiewski J, Roberts SA, Stern PL. The clinical significance of p53 accumulation in gastric carcinoma. Cancer. 1996, ;77:2005-12.
Markiewski M, Domagala W. Immunohistochemical assessment of proliferation rate of breast carcinoma cells using Ki-67, MIB-1 and anti-PCNA monoclonal antibodies. Pol J Pathol. 1996;47(4):189-94.
Markiewski M, Zbislawski W, Marlicz W, Domagala W. Proliferation of cancer cells and stromal cells in colorectal adenocarcinomas as assessed with anti-PCNA/cyclin monoclonal antibody. Pol J Pathol. 1996;47(3):101-4.
Gorczyca W, Markiewski M, Kram A, Tuziak T, Domagala W. Immunohistochemical analysis of bcl-2 and p53 expression in breast carcinomas: their correlation with Ki-67 growth fraction. Virchows Arch. 1995;426(3):229-33.
Bielicki D, Markiewski M, Wielondek M, Chosia M, Domagala W. PCNA defined proliferative activity of epithelial tumor cells in adenomas of the colon. Pol J Pathol. 1995;46(3):151-4.
Domagala W, Harezga B, Szadowska A, Markiewski M, Weber K, Osborn M. Nuclear p53 protein accumulates preferentially in medullary and high-grade ductal but rarely in lobular breast carcinomas. Am J Pathol. 1993 Mar;142(3):669-74.
Woyke S, Markiewski M. Cytodiagnosis of Hodgkin's disease in bronchial brush smears. Patol Pol. 1993;44(1):37-8.
Domagala W, Markiewski M, Kubiak R, Bartkowiak J, Osborn M. Immunohistochemical profile of invasive lobular carcinoma of the breast: predominantly vimentin and p53 protein negative, cathepsin D and oestrogen receptor positive. Virchows Arch A Pathol Anat Histopathol. 1993;423(6):497-502.
Bielicki D, Markiewski M, Marlicz K, Domagala W. PCNA/cyclin defined proliferative activity of epithelial cells in normal gastric mucosa and in chronic gastritis. Patol Pol. 1993;44(2):75-8.
Domagala W, Lasota J, Dukowicz A, Markiewski M, Striker G, Weber K, Osborn M. Vimentin expression appears to be associated with poor prognosis in node-negative ductal NOS breast carcinomas. Am J Pathol. 1990 Dec;137(6):1299-304.
Domagala WM, Markiewski M, Tuziak T, Kram A, Weber K, Osborn M. Immunocytochemistry on fine needle aspirates in paraffin miniblocks. Acta Cytol. 1990 May-Jun;34(3):291-6.
Czerniak B, Chen R, Tuziak T, Markiewski M, Kram A, Gorczyca W, Deitch D, Herz F, Koss LG. Expression of ras oncogene p21 protein in relation to regional spread of human breast carcinomas. Cancer. 1989 May 15;63(10):2008-13.
Czerniak B, Tuziak T, Markiewski M, Kram A, Gorczyca W, Herz F, Koss LG. [Expression of ras oncogenes in early and advanced breast cancer in women] Nowotwory. 1988 May-Jun;38(3):145-51.