Faculty & Staff Details

	Name:	Magdalena Karbowniczek, M.D., Ph.D.
	Position:	Associate Professor
	Email:	magdalena.karbowniczek@ttuhsc.edu
	Bio	Dr. Karbowniczek joined the School of Pharmacy in Abilene as an Associate Professor in the fall of 2010. She is a physician scientist with an interest and background in cancer biology and signaling, molecular pathology, and the pathogenesis of Tuberous Sclerosis Complex. Dr. Karbowniczek came to TTUHSC from Fox Chase Cancer Center where she obtained her postdoctoral training. She is a pathologist and for several years she served as histopatholgy consultant in several medical centers in Poland.

Education:

• M.D. Medicine, Pomeranian Medical University (Szczecin, Poland), 1987-93
• Ph.D. Pathology, Pomeranian Medical University (Szczecin, Poland), 1994-98
• Intern/Resident, Pomeranian Medical University (Szczecin, Poland), 1994-2000
• PDA Tuberous Sclerosis Complex, Fox Chase Cancer Center (Philadelphia, PA), 2001-10

Research Interests:

The research in the Karbowniczek laboratory focuses on the pathogenesis of Tuberous Sclerosis Complex, which a multisystem tumor suppressor gene syndrome caused by germline mutations in TSC1 or TSC2 tumor suppressor genes, and characterized by the development of multiple benign tumors in the central nervous system, as well as renal angiomyolipomas and pulmonary lymphangiomyomatosis (LAM). Dr. Karbowniczek seeks to understand molecular mechanisms that cause this rare, however, often lethal disease.

Publications:

1. Listewnik MH, Chosia M, Tustanowski S, Birkenfeld B, Sadowska B, Karbowniczek M, Krzylak K, Jaroszewicz S, Zalewski H, Uciski M, Kotowicz A, Niedziakowska K. Diagnosis of thyroid tumours based on scintigraphy, ultrasound examinations and FNB (fine needle biopsy): 7 years of experiences. Endokr. Pol. 46:299-300, 1995.
2. Petriczk E, Walczak M, Adamczyk T, Bich W, Elbl B, Karbowniczek M, Wojcik K, Garanty-Bogacka B, Bojko-Czaja I. Incidence of nodular goitre among children in Szczecin region in 1990-1996. Pediat. Prakt. 5(1):150, 1997.
3. Zitek E, Bednarska E, Karbowniczek M, Kordowski J. Rhabdomyoma of the larynx. Cent. East Eur. J. Oto-Rhino-Laryngol. 2(3-4):108, 1997.
4. Karbowniczek M, Chosia M, Domagala W. Nuclear morphometry of MIB-1 positive and negative tumor cells in primary and metastatic malignant melanoma of the skin. Pol. J. Pathol. 50(4):235-241, 1999.
5. Bielicki D, Karbowniczek M, Sulzyc-Bielicka V, Kladny J, Boer C, Marlicz K, Domagala W. Clinico-pathological characteristics of colorectal cancer and serum anti-p53 antibodies. Pol. J. Pathol. 50(2):77-81, 1999.
6. Domagala W, Welcker M, Chosia M, Karbowniczek M, Harezga B, Bartkova J, Bartek J, Osborn M. p21/WAF1/Cip1 expression in invasive ductal breast carcinoma: relationship to p53, proliferation rate, and survival at 5 years. Virchows Arch. 439(2):132-40, 2001.
7. Duffy K, Al-Saleem T, Karbowniczek M, Ewalt D, Prowse AH, Henske EP. Mutational analysis of the von Hippel Lindau gene in clear cell renal carcinomas from tuberous sclerosis complex patients. Mod. Pathol. 15:205-210, 2002.
8. Karbowniczek M, Yu J, Henske EP. Renal angiomyolipomas from patients with sporadic lymphangiomyoma-tosis contain both neoplastic and non-neoplastic vascular structures. Am. J. Pathol. 162:491-500, 2003.
9. Karbowniczek M, Astrinidis A, Balsara BR, Testa JR, Lium JH, Colby TV, McCormack FX, Henske EP. Recurrent lymphangiomyomatosis after transplantation: genetic analyses reveal a metastatic mechanism. Am. J. Resp. Crit. Care Med. 167:976-982, 2003.
10. Karbowniczek M, Cash T, Cheung M, Robertson GP, Astrinidis A, and Henske EP. Regulation of B-Raf kinase activity by tuberin and Rheb is mammalian target of rapamycin (mTOR) independent. J. Biol. Chem. 279:29930-29937, 2004.
11. Karbowniczek M, Henske, EP. The role of tuberin in cellular differentiation: are B-raf and MAPK involved? Ann. NY Acad. Sci. 1059:168-173, 2005.
12. Karbowniczek M, Robertson GP, Henske EP. Rheb inhibits C-Raf activity and B-Raf/C-Raf heterodimerization. J. Biol. Chem. 281:25447-25456, 2006.
13. Robb VA, Karbowniczek M, Klein-Szanto AJ, Henske EP. Activation of the mTOR signaling pathway in renal clear cell carcinoma. J. Urol. 177:346-352, 2007.
14. Lee CH, Inoki K, Karbowniczek M, Petroulakis E, Sonenberg N, Henske EP, Guan KL. Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53. Embo J 26:4812-4823, 2007.
15. Karbowniczek M, Spittle C, Morrison T, Wu H, Henske EP. mTOR is activated in the majority of malignant melanomas. J Invest Dermatol 128:980-987, 2008.
16. Yu J, Robb VA, Morrison T, Ariazi EA, Karbowniczek M, Astrinidis A, Wang C, Hernandez-Cuebas L, Seeholzer L, Nicolas E, Hensley H, Jordan VC, Walker CL, Henske EP. Estrogen promotes the survival and pulmonary metastasis of tuberin-null cells, PNAS 106:2635-40, 2009
17. Karbowniczek M, Zitserman D, Khabibullin D, Hartman T, Yu J, Morrison T, Nicolas E, Squillace R, Roegiers F and Henske EP. The evolutionarily conserved TSC/Rheb patwhay activates Notch in tuberous sclerosis complex and Drosophila external sensory organ development. Journal of Clinical Investigation, 2010. 120(1):93-102.