||Research Assistant Professor
||Dr. Jinhui Zhang joined the Department of Biomedical Sciences in January of 2011. He received his Master`s degree in Medicinal Chemistry and Ph.D. degree in Pathophysiology from Beijing Institute of Radiation Medicine, China. He continued his postdoctoral training in the field of genomics/transcriptomics/proteomics of cancer and diabetes at the University of Minnesota and the University of South Carolina. His primary research interests focus on the mechanisms of prostate carcinogenesis and new chemo-preventive agent discovery and development.
Ph.D. in Pathology and Pathophysiology, 2000 Beijing Institute of Radiation Medicine, China
M.S. in Medicinal Chemistry, 1997 Beijing Institute of RadiationMedicine, China
B.S. in Biochemistry, 1994 Nan Kai University, China
Postdoctoral research associate, 2005-2007 Department of Food Science and Nutrition
University of Minnesota
Postdoctoral research fellow, 2002-2005 South Carolina Cancer Center
University of South Carolina
My current research involves: 1) identification and functional study of targets for prostate cancer chemo-prevention through geno-proteomic approach; 2) development of new chemo-preventive agents (natural or synthesized compounds), including activity based purification, in vitro/in vivo activity evaluation, pharmacokinetics and molecular cellular mechanisms.
Jinhui Zhang, Lei Wang, Yong Zhang, Li Li, LeeAnn Higgins, Junxuan Lü. Lobe-specific proteome changes in the dorsal-lateral and ventral prostate of TRAMP mice vs. wild type mice. Proteomics, accept.
Jinhui Zhang, Lei Wang, Guangxun Li, Lorraine B. Anderson, Yanji Xu, Bruce Witthuhn, Junxuan Lu. Mouse prostate proteomes are differentially altered by supranutritional intake of four selenium compounds. Nutrition and Cancer, accept
Lei Wang, Jinhui Zhang, Yong Zhang, Katai Nkhata, Emily Quealy, Joshua D Liao, Margot P Cleary, Junxuan Lü. Lobe-specific lineages of carcinogenesis in the transgenic adenocarcinoma of mouse prostate and their responses to chemopreventive selenium. The Prostate, 2011 Feb 25. doi: 10.1002/pros.21360. [Epub ahead of print]
Li Li, Ahmad Ali Shaik, Jinhui Zhang, Katai Nhkata, Lei Wang, Yong Zhang, Chengguo Xing, Sung-Hoon Kim, Junxuan Lü. Preparation of Penta-O-galloyl-ß-D-glucose from tannic acid and plasma pharmacokinetic Analyses by Liquid-Liquid Extraction and Reverse-Phase HPLC. Journal of Pharmaceutical and Biomedical Analysis, 2011, 54(3):545-50.
Jinhui Zhang, Lei Wang, Lorraine B. Anderson, Bruce Witthuhn, Yanji Xu, Junxuan Lü. Proteomic profiling of potential molecular targets of methyl-selenium compounds in the transgenic adenocarcinoma of mouse prostate model. Cancer prevention Research, 2010, 3(8): 994-1006.
Yong Zhang, Jinhui Zhang, Lei Wang, Emily Quealy, Bernard D. Gary, Robert C. Reynolds, Gary A. Piazza, Junxuan Lü. A novel sulindac derivative lacking COX-inhibitory activities suppresses carcinogenesis in the transgenic adenocarcinoma of mouse prostate model. Cancer prevention Research, 2010, 3 (7):885-895.
Yoshiyuki Mizushina, Jinhui Zhang, Angelo Pugliese, Junxuan Lü. Anti-cancer gallotannin penta-O-galloyl-beta-D-glucose is a nanomolar inhibitor of select mammalian DNA polymerases. Biochemical Pharmacology, 2010, 80 (8): 1125-1132.
Hongbo Hu, Jinhui Zhang, Hyo-Jeong Lee, Sung-Hoon Kim, Junxuan Lü Penta-O-galloyl-beta-D-glucose induction of G1 and S cell cycle arrests in prostate cancer cells targeting cyclin D1 and DNA replication. Carcinogenesis, 2009, 30 (5):818-823.
Jinhui Zhang, Li Li, Sung-Hoon Kim, Ann E. Hagerman, Junxuan Lü Anti-cancer, anti-diabetic and other pharmacologic and biological activities of penta-galloyl-glucose (expert review). Pharmaceutical Research, 2009, 26(9):2066-80.
Zhihong Gong, Roberd M. Bostick, Dawen Xie, Thomas G. Hurley, Zonglin Deng, Dan A. Dixon, Jinhui Zhang, James R. Hebert Cyclooxygenase 1 and 2 Gene Polymorphisms and Risk of Colorectal Adenoma. International Journal of Colorectal Disease, 2009, 24(6): 647-654.
Jinhui Zhang, Yingjie Wu, Derek. LeRoith, David A. Bernlohr, Xiaoli. Chen. Functional characterization of a new adipokine involved in adipocyte insulin resistance and inflammation. Molecular Endocrinology, 2008, 22(6): 1416-1426
Jinhui Zhang, Wendy Wright, David A. Bernlohr, Xiaoli Chen. Alterations of the classic pathway of complement in adipose tissue of obesity and insulin resistance. American Journal of Physiology: Endocrinology and Metabolism, 2007, 292(5):E1433-E1440
Lisheng Wang, Hongjun Liu, Jinhui Zhang, Chutse Wu. Purging effect of dibutyl phthalate on leukemia cells involves fas independent activation of caspase-3/CPP32 protease. Cancer Letter 2002 Dec 5; 186(2):177-821.
Junlin Li, Jinhui Zhang, Chutse Wu. Antineoplasic effect of ECG( (-) epicatechin gallate) from Rheum officinale Baill. Chinese Traditional and Herbal Drugs, 2000, 23:120-121
Jinhui Zhang, Zhonghua Jiang, Huipeng Chen, Liren Ma. Advances in affinity chromatography, Chinese Journal of Chromatography, 1999, 17(3):253-256.
Active Member, American Chemical Society (ACS)
Active Member, American Association for Cancer Research (AACR)