 |
Name: |
Junxuan "Johnny" Lu |
| Position: |
Chair and Professor |
| Email: |
Junxuan.Lu@ttuhsc.edu |
| Bio |
Dr. Lu joined TTUHSC-SOP in January of 2011 as professor and chair of the school’s new Department of Biomedical Sciences. His vision for the department’s research is: “new department, new biology, new targets and new drugs.”
Dr. Lu received his Ph.D. in animal science/nutrition in January 1989 from Cornell University in Ithaca, N.Y. He carried out his postdoctoral work at Cornell in nutritional biochemistry (1988-1989) and molecular and cellular biology (1989-1991). He was an associate scientist (assistant professor rank, 1992-1999) and scientist (associate professor rank, 1999-2002) at the AMC Cancer Research Center in Denver, CO. In October 2002, Dr. Lu joined the Hormel Institute University of Minnesota where he led the Section of Cancer Biology as an associate professor (2002-2006) and professor (2006-2011).
|
Education:
Undergraduate Education
Bachelor of Science in Biochemistry, Wuhan University, Wuhan, China, 1982
Graduate Education,
Doctor of Philosophy in Animal Science/Nutrition, Department of Poultry and Avian Sciences, Cornell University, Ithaca, N.Y., 1989
Postdoctoral Education
Postdoctoral Research Associate in Nutritional biochemistry from October 1988 to October 1989, Department of Poultry and Avian Sciences, Cornell University, Ithaca, N.Y.,
Postdoctoral Research Associate in Molecular and Cellular Biology from November 1989 to December 1991. Section of Biochem, Cell and Molecular Biology, Cornell University, Ithaca, N.Y.,
Research Interests:
Dr. Lu’s research is focused on prostate and mammary carcinogenesis and chemoprevention. His current National Institutes of Health (NIH) funded research involves selenium compounds for cancer chemoprevention and the identification and development of novel cancer chemopreventive and therapeutic agents from Chinese and Oriental medicinal herbs and natural products. In terms of the biological processes, his research work involves apoptosis, cell cycle regulation, angiogenesis, protein kinase signal transduction pathways and sex steroid hormone function in prostate and breast cancer.
Dr. Lu’s research effort is currently supported by NIH (NCI, NCCAM) R01 and R21 funding. At TTUHSC-SOP, his team and colleagues are taking on a drug discovery initiative through “ph/farmacognosy” of Texas-grown and native plants for cancer chemoprevention and treatment, in collaboration with the Texas A&M University Agri-life Research and Extension in Amarillo. The overarching goal is an integrated drug discovery and development research and training infrastructure for the Texas High Plains (farm-bench-bedside care).
Publications:
Wang L, Zhang J, Zhang Y, Nkhata K, Quealy E, Liao JD, Cleary MP, Lü J. Lobe-specific lineages of carcinogenesis in the transgenic adenocarcinoma of mouse prostate and their responses to chemopreventive selenium. Prostate 2011 Feb 25. [Epub ahead of print]
Zhang Y, Kim KH, Zhang W, Guo Y, Kim SH, Lü J. Galbanic acid decreases androgen receptor abundance and signaling and induces G(1) arrest in prostate cancer cells. Int J Cancer. 2011 Feb 15. [Epub ahead of print]
Yin S, Dong Y, Li J, Lü J, Hu H. Penta-1,2,3,4,6-O-galloyl-beta-D-glucose induces senescence-like terminal S-phase arrest in human hepatoma and breast cancer cells. Mol Carcinog. 2011 Feb 11. [Epub ahead of print]
Kim KH, Lee HJ, Jeong SJ, Lee HJ, Lee EO, Kim HS, Zhang Y, Ryu SY, Lee MH, Lü J, Kim SH. Galbanic Acid Isolated from Ferula assafoetida Exerts In Vivo Anti-tumor Activity in Association with Anti-angiogenesis and Anti-proliferation. Pharm Res. 2011 Mar;28(3):597-609. Epub 2010 Nov 10.
Li Li, Ahmad Ali Shaik, Jinhui Zhang, Katai Nhkata, Lei Wang, Yong Zhang, Chengguo Xing, Sung-Hoon Kim, and Junxuan Lü. Preparation of Penta-O-galloyl-ß-D-glucose from tannic acid and plasma pharmacokinetic Analyses by Liquid-Liquid Extraction and Reverse-Phase HPLC. Journal of Pharmaceutical and Biomedical Analysis. 2010 Sep 29. [Epub ahead of print]
Jinhui Zhang, Lei Wang, Lorraine B. Anderson, Bruce Witthuhn, Yanji Xu and Junxuan Lü.
Proteomic profiling of potential molecular targets of methyl-selenium compounds in the transgenic adenocarcinoma of mouse prostate model. Cancer Prev Res (Phila Pa). 2010 Aug; 3(8):994-1006. Epub 2010 Jul 20.
Yong Zhang, Jinhui Zhang, Lei Wang, Emily Quealy, Bernard D. Gary, Robert C. Reynolds, Gary A. Piazza and Junxuan Lü, A novel sulindac derivative lacking COX-inhibitory activities suppresses carcinogenesis in the transgenic adenocarcinoma of mouse prostate model. Cancer Prev Res, 2010 Jul; 3(7):885-95. Epub 2010 Jun 29.
Wang Z, Lee HJ, Chai Y, Hu H, Wang L, Zhang Y, Jiang C, Lü J. Persistent P21Cip1 Induction Mediates G(1) Cell Cycle Arrest by Methylseleninic Acid in DU145 Prostate Cancer Cells.
Curr Cancer Drug Targets. 2010 Apr 6. [Epub ahead of print]
Chai Y, Lee HJ, Shaik AA, Nkhata K, Xing C, Zhang J, Jeong SJ, Kim SH, Lu J.
Penta-O-galloyl-beta-D-glucose induces G1 arrest and DNA replicative S-phase arrest independently of cyclin-dependent kinase inhibitor 1A, cyclin-dependent kinase inhibitor 1B and P53 in human breast cancer cells and is orally active against triple negative xenograft growth.
Breast Cancer Res. 2010 Sep 1;12(5):R67. [Epub ahead of print]
Mizushina Y, Zhang J, Pugliese A, Kim SH, Lü J. Anti-cancer gallotannin penta-O-galloyl-beta-d-glucose is a nanomolar inhibitor of select mammalian DNA polymerases. Biochem Pharmacol. 2010 Oct 15;80(8):1125-32. Jun 26. [Epub ahead of print]
Won SH, Lee HJ, Jeong SJ, Lee HJ, Lee EO, Jung DB, Shin JM, Kwon TR, Yun SM, Lee MH, Choi SH, Lü J, Kim SH. Tanshinone IIA Induces Mitochondria Dependent Apoptosis in Prostate Cancer Cells in Association with an Inhibition of Phosphoinositide 3-Kinase/AKT Pathway. Biol Pharm Bull. 2010;33(11):1828-34.
Lee JH, Choi S, Lee Y, Lee HJ, Kim KH, Ahn KS, Bae H, Lee HJ, Lee EO, Ahn KS, Ryu SY, Lü J, Kim SH. Herbal compound farnesiferol C exerts antiangiogenic and antitumor activity and targets multiple aspects of VEGFR1 (Flt1) or VEGFR2 (Flk1) signaling cascades.
Mol Cancer Ther. 2010 Feb;9(2):389-99. Epub 2010 Jan 26.
Hu H, Chai Y, Wang L, Zhang J, Lee HJ, Kim SH, Lü J. Pentagalloylglucose induces autophagy and caspase-independent programmed deaths in human PC-3 and mouse TRAMP-C2 prostate cancer cells. Mol Cancer Ther. 2009 Oct;8(10):2833-43.
Hongbo Hu, Jinhui Zhang, Hyo Jeong Lee, Sung-Hoon Kim, Junxuan Lü Penta-O-galloyl-beta-D-glucose induces S- and G1-cell cycle arrests in prostate cancer cells targeting DNA replication and cyclin D1. Carcinogenesis 2009 May;30(5):818-23. Epub 2009 Mar 6.
Lei Wang, Melissa J. L. Bonorden, Guang-xun Li, Hyo-Jeong Lee, Hongbo Hu, Yong Zhang, Joshua D. Liao, Margot P. Cleary and Junxuan Lü Methyl-selenium compounds inhibit prostate carcinogenesis in the transgenic adenocarcinoma of mouse prostate model with survival benefit. Cancer Prevention Res, 2009 May;2(5):484-95. Epub 2009 Apr 28.
Lee, H-Je, Lee, H-Ju, Lee, E-O, Lee, J-H, Lee, K-S, Kim K-H, Kim, S-H and Lü, J. In vivo Anti-Cancer Activity of Korean Angelica gigas and its Major Pyranocoumarin Decursin. American Journal of Chinese Medicine. 2009, 37(1):127-42.
Zhe Wang, Hyo-Jeong Lee, Lei Wang, Cheng Jiang, Nam-In Baek, Sung-Hoon Kim and Junxuan Lü. Anti-androgen receptor signaling and prostate cancer inhibitory effects of sucrose- and benzophenone-compounds Pharmaceutical Res., 2009. May;26(5):1140-8. Epub 2009 Mar 6.
Weiqin Jiang, Cheng Jiang, Hongying Pei, Lei Wang, Jinhui Zhang, Hongbo Hu, and Junxuan Lü. In vivo molecular mediators of cancer growth suppression and apoptosis by selenium in mammary and prostate models: lack of involvement of gadd genes. Mol Cancer Ther, 2009, Mar;8(3):682-91. Epub 2009 Mar 10.
H Hu, H-J Lee, C Jiang, J Zhang, L Wang, Y Zhao, Qiu Xiang, E-O Lee, S-H Kim, J. Lü Penta-O-galloyl-beta-D-glucose induces p53 and inhibits STAT3 in prostate cancer cells in vitro and suppresses prostate xenograft tumor growth in vivo. Mol Cancer Ther., 2008 Sep;7(9):2681-91.
Hu H, Li GX, Wang L, Watts J, Combs GF Jr, Lü J. Methylseleninic acid enhances taxane drug efficacy against human prostate cancer and down-regulates antiapoptotic proteins Bcl-XL and survivin. Clin Cancer Res. 2008 Feb 15; 14(4): 1150-8.
Li, GX, Lee HJ, Wang Z, Hu H, Liao JD, Watts J, Combs GF Jr, Lü J. Superior in vivo inhibitory efficacy of methylseleninic acid against human prostate cancer over selenomethionine or selenite. Carcinogenesis. 2008 May;29(5):1005-12. [Epub ahead of print]
Wang, Z., Hu, H., Li, G., Lee, HJ., Jiang, C., Kim, SH., Lü, J. Methylseleninic acid inhibits microvascular endothelial G(1) cell cycle progression and decreases tumor microvessel density. Int J Cancer. Jan 1;122(1):15-24, 2008.
Koo JS, Choi WC, Rhee YH, Lee HJ, Lee EO, Ahn KS, Bae HS, Ahn KS, Kang JM, Choi SU, Kim MO, Lu J, Kim SH. Quinoline derivative KB3-1 potentiates paclitaxel induced cytotoxicity and cycle arrest via multidrug resistance reversal in MES-SA/DX5 cancer cells. Life Sci. 2008 Nov 21;83(21-22):700-8. Epub 2008 Sep 24.
Lee HJ, Lee HJ, Lee EO, Ko SG, Bae HS, Kim CH, Ahn KS, Lu J, Kim SH. Mitochondria-cytochrome C-caspase-9 cascade mediates isorhamnetin-induced apoptosis. Cancer Lett. 2008 Nov 8;270(2):342-53. Epub 2008 Jul 9.
Jiang C, Guo J, Wang Z, Xiao B, Lee HJ, Lee EO, Kim SH, Lü J. Decursin and decursinol angelate inhibit estrogen-stimulated and estrogen-independent growth and survival of breast cancer cells. Breast Cancer Res. Nov 6;9(6):R77, 2007.
Li, G., Hu, H., Jiang, C., Schuster, T., Lu, J. Differential involvement of reactive oxygen species in apoptosis induced by two classes of selenium compounds in human prostate cancer cells. Int. J. Cancer. May 1;120(9):2034-43, 2007.
Guo, J., Jiang, C., Wang, Z., Malewicz, B., Lee, H-J., Hu, H., Baek, N-I., Kang, K-S., Kim, S-H. and Lu, J.. A novel class of pyranocoumarin anti-androgen receptor signaling compounds. Mol Cancer Ther. Mar;6(3):907-17., 2007.
Lee, H.J., Lee, H.J., Song, G.Y., Li, G.X., Lee, J.H., Lu, J., Kim, S.H., 6-(1-Oxobutyl)-5,8-dimethoxy-1,4-naphtoquinone inhibits Lewis lung cancer by anti-angiogenesis and apoptosis. Int. J. Cancer. Jun 1;120(11):2481-90, 2007.
Jiang C, Lee HJ, Li GX, Guo J, Malewicz B, Zhao Y, Lee EO, Lee HJ, Lee JH, Kim MS, Kim SH, Lu J. Potent antiandrogen and androgen receptor activities of an Angelica gigas-containing herbal formulation: identification of decursin as a novel and active compound with implications for prevention and treatment of prostate cancer. Cancer Res. 2006 Jan 1;66(1):453-63.
Malewicz B, Wang Z, Jiang C, Guo J, Cleary MP, Grande JP, Lu J. Enhancement of mammary carcinogenesis in two rodent models by silymarin dietary supplements. Carcinogenesis. 2006 Sep;27(9):1739-47. Epub 2006 Apr 5.
Hu H, Jiang C, Schuster T, Li GX, Daniel PT, Lu J. Inorganic selenium sensitizes prostate cancer cells to TRAIL-induced apoptosis through superoxide/p53/Bax-mediated activation of mitochondrial pathway. Mol Cancer Ther. 2006 Jul;5(7):1873-82.
Lee HJ, Lee EO, Rhee YH, Ahn KS, Li GX, Jiang C, Lu J, Kim SH. An oriental herbal cocktail, ka-mi-kae-kyuk-tang, exerts anti-cancer activities by targeting angiogenesis, apoptosis and metastasis. Carcinogenesis. 2006 Jun 15; [Epub ahead of print]
Lee EO, Lee HJ, Hwang HS, Ahn KS, Chae C, Kang KS, Lu J, Kim SH. Potent inhibition of Lewis lung cancer growth by heyneanol A from the roots of Vitis amurensis through apoptotic and anti-angiogenic activities. Carcinogenesis. 2006 Oct;27(10):2059-69. Epub 2006 May 4.
Selected Book chapters and invited
reviews
Jinhui Zhang, Li Li, Sung-Hoon Kim, Ann E. Hagerman and Junxuan Lü. Anti-Cancer, Anti-Diabetic and Other Pharmacologic and Biological Activities of Penta-Galloyl-Glucose. Expert review. Pharmaceutical Res. 2009 Sep; 26(9): 2066-80. Epub 2009 Jul 2.
Junxuan Lü, Hongbo Hu and Cheng Jiang. Regulation of signaling pathways by selenium in cancer. Invited book chapter: Dietary Modulation of Cell Signaling Pathways, Edited by Y-J Surh, L Packer, Z Dong, E Cadenas. CRC Press (Taylor & Francis Group). Chapter 11, pp274-314, 2008.
Lü, J., Kim, SH., Jiang C., Lee, H., Guo, J. Oriental herbs as a source of novel anti-androgen and prostate cancer chemopreventive agents. Acta Pharmacol Sin. Sep;28(9):1365-72, 2007.
Lu J, Jiang C. Selenium and cancer chemoprevention: hypotheses integrating the actions of selenoproteins and selenium metabolites in epithelial and non-epithelial target cells. Antioxid Redox Signal. 2005 Nov-Dec;7(11-12): 1715-1727. Invited review.
