Faculty & Staff Details

	Name:	Margaret Weis
	Position:	Associate Professor
	Email:	margaret.weis@ttuhsc.edu
	Bio	Margaret T. Weis, Ph.D., is an Associate Professor of Biomedical Sciences. Dr. Weis earned a Bachelor of Science degree from Loyola University, Chicago, Illinois. After working for Ortho Pharmaceutical Corporation, she earned her Ph.D. in pharmacology/molecular biology from the Medical University of South Carolina. She completed a postdoctoral fellowship at the University of Tennessee Medical School in Memphis, and then joined the faculty there as an instructor. Dr Weis served on the faculty of The Philadelphia College of Pharmacy as an Assistant and Associate Professor before joining the Department of Pharmaceutical Sciences at Texas Tech in 1999.

Research Interests:

Cardiac enzymes responsible for fatty acid metabolism, their expression & regulation.

Publications:

PEER REVIEWED PUBLICATIONS:

S.S. Asculai*, M.T. Weis, M.W. Rancourt and A.B. Kupferberg. Inactivation of herpes simplex virus by nonionic surfactants. Antimicrobial Agents and Chemotherapy, 13 : 686-690, 1978.

M.T. Weis and K.U. Malik*. Beta adrenergic receptor stimulated prostaglandin synthesis in the isolated rabbit heart: Relation to extra- and intra-cellular calcium. J.Pharmacol.Exp.Ther., 235 : 178-185, 1985.

M.T. Weis and K.U. Malik*. Calcium regulation of arachidonic acid metabolism in the isolated perfused rabbit heart. Circ.Res., 59 : 694-703, 1986.

K.U. Malik*, M.T. Weis and N. Jaiswal. Mechanism of action of adrenergic and cholinergic stimuli on cardiac prostaglandin synthesis. Adv. Prost. Thrombox. Leuk. Res., 19:327-330, 1989.

M.T. Weis* and K.U. Malik. Uptake and hormonally induced hydrolysis of [3H]phosphatidyl choline in the perfused rabbit heart. J. Pharmacol. Exp. Ther., 248 : 614-620, 1989.

M.T. Weis* and K.U. Malik. Influence of mono and divalent cations on the cardiac metabolism of arachidonic acid. Prostaglandins. 37:707-723, 1989.

M.T. Weis*, A.J. Palazzo, J.L. Williams Jr., and K.U. Malik. Uptake, incorporation and metabolism of [3H]triolein in the isolated perfused rabbit heart. Lipids, 25 : 497-503, 1990.

A. Palazzo, K.U. Malik and M.T. Weis*. Vasopressin stimulates the mobilization and metabolism of triacylglycerol in the isolated perfused rabbit heart. American Journal of Physiology. 260:H604-H612, 1991.

M.T. Weis*. Magnesium influences the incorporation of [3H] arachidonic acid in the perfused rabbit heart. Am. J. of Physiology,. 265:H83-H90, 1993

M.T. Weis* and C. Saunders. Magnesium and Arachidonic Acid Metabolism. (Invited Review). Magnesium Research, 6:179-190, 1993

C. Saunders, J.M. Voigt and M.T. Weis*. Rabbit heart has only one long-chain fatty acyl CoA synthetase, which is regulated by magnesium. Biochemical Journal, 313:849-853, 1996

M.Weis* and A. Bercute. Comparison of Long-Chain Fatty Acyl CoA Synthetases From Rabbit Heart and Liver: Substrate Preferences and Effects of Mg2+. Biochemical Journal, 322:649-654, 1997

L. Young, A. Bercute and M.T. Weis*. Mg2+ efflux from the isolated perfused rabbit heart is mediatred by two states of the ?1 adrenergic receptor., Naunyn-Schmiedeberg’s Arch. of Pharmacol. 366:431-439, 2002

M. Uberti, J. Pierce and M.T. Weis*. Molecular characterization of a rabbit long-chain fatty acyl CoA synthetase unique to the vascular endothelium. Biochem. Biophys. Acta, 1645:193-204, 2003.

M.T. Weis*, J. Crumley, L.H. Young, J.N. Stallone. Inhibiting long chain fatty acyl CoA synthetase increases basal and agonist-stimulated NO synthesis in endothelium. Cardiovascular Research, 63:338-346, 2004

Weis, M.T. , Brady, M., Moore, M., Crumley, J., Stallone, J.N. Inhibiting long chain fatty acyl CoA synthetase does not increase agonist-induced release of arachidonate metabolites from human endothelial cells. J. Vascular Res. 42:275-283, 2005.

Young, L.H., Balin, B.J., Weis, M.T. Gö 6983: A fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury. Cardiovascular Drug Reviews. 23:262-279, 2005.

Bazinet, R.P., Weis, M.T. , Rapoport, S.I., Rosenberger, T.A. Valproic acid inhibits brain microsomal long chain fatty acyl CoA synthetase at therapeutically relevant concentrations. In final revision, Psychopharmacology

Rosenberger, T.A., Villacreses, N.E., Weis, M.T. , Rapoport, S.I. Rat brain docosahexaenoic acid metabolism is not altered by a 6-day intracerebral ventricular infusion of bacterial lipopolysaccharide. Submitted to: J. Neurochem;


ABSTRACTS:

M.T. Weis, J.M. Killinger and B.L. Fuller. Characterization of PGF?? binding sites in leutinized rat ovaries. Fed.Proc., 38:407, 1979.

M.T. Weis and P.V. Halushka. [3H]PGE1 binds to toad (Bufo marinus) urinary bladder epithelial cells. Fed.Proc., 39:996, 1980.

M.T. Weis and P.V. Halushka. Prostaglandin inhibition of vasopressin-stimulated water flow in the toad urinary bladder: Correlation with displacement of bound [3H]PGE1. Fed.Proc., 41:1544, 1982.

M.T. Weis and K.U. Malik. Effects of altered extracellular Ca2+ and of calmodulin inhibitors on prostaglandin synthesis elicited by isoproterenol in the isolated rabbit heart. Fed.Proc, 43:932, 1984.

M.T. Weis and K.U. Malik. Isoproterenol induced prostaglandin synthesis in the isolated rabbit heart: Effect of calcium depletion and extra-and intracellular calcium antagonists. Pharmacologist, 26:155, 1984.

M.T. Weis and K.U. Malik. Enhanced metabolism of arachidonic acid to prostaglandins in the absence of extracellular calcium in the isolated rabbit heart. Fed.Proc., 44:902, 1985.

M.T. Weis and K.U. Malik. The influence of Ca2+ on the acylation of fatty acids in the isolated perfused rabbit heart. Pharmacologist, 27:176, 1985.

M.T. Weis and K.U. Malik. Calcium regulation of cardiac arachidonate metabolism. Fed.Proc., 1986.

L.M. Porterfield, M.A. Chryssanthis, M.T. Weis, and R.W. Caldwell. Binding and actions of a polar aminocardenolide, ASI-222, to isolated canine heart cells. Circulation, October, 1986.

M.T. Weis, and K.U. Malik. Uptake and distribution of [3H] phosphatidyl choline (PC) in tissue lipids in the isolated perfused rabbit heart: Influence of hormones on its metabolism. Fed.Proc., 1987.

A. Palazzo, M.T. Weis, J.L. Williams, Jr., and K.U. Malik. Selective incorporation of [3H]triolein into triglyceride pool and its metabolism in response to vasopressin in the isolated rabbit heart. Fed.Proc., 1987.

J.L. Williams, Jr., M.T. Weis and K.U. Malik. Hormone-stimulated lipolysis in perfused rabbit heart: Contribution of Ca2+. Fed.Proc., 1987.

M.T. Weis, A.J. Palazzo and K.U. Malik. Hormonally induced lipolysis in the isolated rabbit heart labeled with [3H]triolein. F.A.S.E.B. Journal, 2:1309, 1988.

M.T. Weis. Vasopressin-stimulated cardiac triacylglycerol metabolism is mediated by V1 receptors. F.A.S.E.B. Journal, 4:A596, 1990.

C. Saunders and M. Weis. Arachidonic acid is incorporated in preference to oleic acid in the isolated perfused rabbit heart. F.A.S.E.B. Journal, 5:A1425, 1991.

M.T. Weis. The incorporation of [3H]arachidonic acid (AA) in the isolated perfused rabbit heart is influenced by tissue magnesium (Mg2+). F.A.S.E.B. Journal, 6:A1950, 1992.

C. Saunders and M.T. Weis. The rabbit heart has only one fatty acyl-CoA synthetase, which shows no preference for arachidonic acid. F.A.S.E.B. Journal, 6:A969, 1992.

A.J. Kihm and M.T. Weis. The incorporation of [3H]triolein and [3H]oleate in the rabbit heart. F.A.S.E.B. Journal, 6:A967, 1992.

C. Saunders and M.T. Weis. The absence of arachidonoyl CoA synthetase in rabbit heart. F.A.S.E.B. Journal, 7:A383, 1993

A. Kihm and M.T. Weis. Uptake of [3H]triolein and [3H]oleate in the rabbit heart. F.A.S.E.B. Journal, 7:A383, 1993

A. Kihm, R. Tchao and M.T. Weis. Flux of [3H]triolein and [14C] albumin across coronary microvascular endothelial (RCME) cells. F.A.S.E.B. Journal, 8:A623, 1994.

C. Saunders and M.T. Weis. Lysophosphatidylcholine acyltransferase (LPC AT) activity in rabbit heart: Selectivity for arachidonyl CoA (AACoA). F.A.S.E.B. Journal, 8:A731, 1994.

M.T. Weis Magnesium (Mg2+) and the acylation of arachidonic acid (AA): Evidence for Mg2+ regulation of long-chain fatty acyl CoA synthetase. F.A.S.E.B. Journal, 8:A432, 1994.

M.T. Weis and A. Bercute. Magnesium regulation of long-chain fatty acyl CoA synthetases. F.A.S.E.B. Journal, 10:A782, 1996.

C.A. Weiss and M.T.Weis. Promoting student problem solving in a large lecture setting. F.A.S.E.B. Journal, 10:A267, 1996.

M.T. Weis. Inhibiting Ca2+ independent phospholipase A2 (Ca2+i-PLA2) increases isoproterenol (ISO)-induced release of [3H]arachidonic acid (AA) from perfused rabbit hearts. F.A.S.E.B. Journal, 11:1997

M.T. Weis. Dimethylsulfoxide (DMSO) attenuates the pressor response to vasopressin (AVP) in isolated perfused rabbit hearts. Vascular Biology '97 (N.A.V.B.O.)

M.T. Weis. ?-adrenergic receptor (?AR) subtypes and Mg2+ efflux from the isolated perfused rabbit heart. F.A.S.E.B. Journal, 12:1998

M. Uberti and M.T.Weis. Immunochemical characterization of long-chain fatty acyl coA synthetase(s) in rabbit heart and liver. F.A.S.E.B. Journal, 12:1998

M. Uberti and M.T. Weis. Immunofluorescent analysis indicates that long chain fatty acyl CoA synthetase is localized in the rabbit vascular endothelium. F.A.S.E.B. Journal, 13:A861, 1999.

M.T. Weis* and M. Uberti. Long chain fatty acyl CoA synthetase from vascular smooth muscle and vascular endothelium are not immunologically cross-reactive. F.A.S.E.B. Journal 13:A861, 1999.

M. Uberti, J.C. Pierce and M.T. Weis*. Characterization of an endothelial long-chain fatty acyl CoA synthetase (LCFACoAS). Journal of Submicroscopic Cytology and Pathology, 32:473, 2000

M. Uberti, J.C. Pierce, and M.T. Weis*. Rabbit heart long chain fatty acyl CoA synthetase (LCFACoAS) is localized in the vascular endothelium. FASEB Journal 14:A575, 2000.

M.T. Weis*. Inhibiting human coronary vascular endothelial cell long chain fatty acyl CoA synthetase increases nitric oxide synthesis. FASEB Journal 15:A452, 2001.

M.T. Weis* and J. Crumley. Endothelial long chain fatty acyl CoA synthetase regulates endothelial nitric oxide synthetase activity. F.A.S.E.B. Journal 16,A442, 2002

M.T. Weis* and J.N. Stallone. Endothelial long chain fatty acyl CoA synthetase activity is up-regulated in ovariectomized rats. F.A.S.E.B. Journal 17: A124, 2003.

M.T. Weis* and J.N. Stallone. Endothelial long chain fatty acyl CoA synthetase activity is up-regulated in ovariectomized rats. E.S.C.I meeting, Verona, Italy, 2003.

Weis, M.T. , Stallone, J.N., Young, L.H. Inhibiting endothelial long chain fatty acyl CoA synthetase (eLCFACoAS) increases methacholine (MeCh) stimulated nitric oxide synthesis and vascular relaxation in rat aorta. Experimental Biology 2004, Abstract #819.7

Weis, M.T. , M. Brady, M. Moore, and J.N. Stallone. Inhibiting long chaing fatty acyl CoA synthetase does not increase agonist-induced release of eicosanoids from human endothelial cells. Experimental Biology 2005, Program # 396.19

R.P. Bazinet, T.A. Rosenberger, S.I. Rapop0ort and M.T. Weis. Valproic acid inhibits brain microsomal fatty acyl CoA synthetases at physiologically relevant concentrations. Experimental Biology 2005, Program # 517.8

M. Li, M.M. Sellers, M.T. Weis and J.N. Stallone. Vascular prostanoid crosstalk: thromboxane atttenuates prostacyclin production in male and female rat aortae. Experimental Biology 2005, Program # 937.22