M.D. - Pomeranian Medical University, Szczecin, Poland
Ph.D. - Pomeranian Medical University, Szczecin, Poland
Residency in Anatomic Pathology - Pomeranian Medical University, Szczecin, Poland
Postdoctoral training – Fox Chase Cancer Center, Philadelphia, PA
Instructor, Pomeranian Medical University, Szczecin, Poland (1993-2000)
Resident pathologist, Regional Cancer Center, Szczecin, Poland (2000)
Postdoctoral Associate, Fox Chase Cancer Center, Philadelphia (2001-2010)
Dr. Magdalena Karbowniczek received her M.D. in 1993 and Ph.D. in tumor pathology in 1998 from Pomeranian Medical University in Poland. She is also board certified in Anatomic Pathology and served as a histopathology consultant for several years prior to coming to the USA. She received her postdoctoral training in Dr. Elizabeth Henske’s laboratory at the Fox Chase Cancer Center, Philadelphia.
I am a physician scientist with an interest in cancer biology and signaling, molecular pathology and the pathogenesis of peripheral manifestation of Tuberous Sclerosis Complex (TSC) such as pulmonary lymphangioleiomyomatosis (LAM) and renal angiomyolipomas. By using morphological and genetic approaches we have found that morphologically benign pulmonary LAM cells can migrate or metastasize in vivo to a transplanted lung, and that all components of angiomyolipomas arise from common precursor cell and exhibit differentiation plasticity. Thus, examining the impact of TSC proteins on TSC pathogenesis related to the cell differentiation and survival is the major objective of our present research. Currently we utilize conditional mouse knockouts and Drosophila external sensory organ models to investigate TSC pathogenesis, mesenchymal stem cell differentiation and tumorigenesis in vivo.