Dr. Maciej Markiewski received his M.D. in 1990 and Ph.D. in tumor pathology in 1995 from Pomeranian Medical University in Poland. He is also board certified in Anatomic Pathology and served as a histopathology consultant for several years prior to coming to the USA. He received his postdoctoral training in immunology in Dr. John Lambris’ laboratory at the University of Pennsylvania where he was also a research associate and a senior research investigator.
I am a physician-scientist with an interest and expertise in innate immunity, complement and tumor immunology. My laboratory conducts research on roles of the complement system and innate immunity in the tumor microenvironment, cancer development and progression. We strive to develop new forms of cancer immunotherapy that target this component of the immune system. Our study published in Nature Immunology was the first one to demonstrate that the complement anaphylatoxin C5a promotes growth of malignant tumors. This work has shifted a paradigm related to the role of complement in cancer, as for decades it was thought that complement proteins contribute to killing tumor cells similar to their functions in killing bacteria. These findings build a foundation for future research in our laboratory.