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Profile for Irene La-Beck, PharmD

Irene La-Beck

Irene La-Beck, PharmD

  • Committee Chair
Office Phone: 325-696-0433
Email: irene.la-beck@ttuhsc.edu
Mail Address: 1718 Pine St
Abilene TX 79601-3044

Biography

I have a broad background in clinical pharmacology with specific training and expertise in anticancer nanoparticles. At the University of North Carolina (UNC), I used mouse models and clinical studies in cancer patients to investigate phenotypic probes of the mononuclear phagocyte system as biomarkers for personalizing therapy with anticancer liposomes. I also investigated the preclinical and clinical pharmacokinetics of novel anticancer nanoparticles such as Stealth liposomal CKD-602 (a camptothecin analogue), Optisomal topotecan, and folate-targeted polyethylene glycol- and gadolinium-PRINT (particle replication in non-wetting template)-nanoparticles. I joined the School of Pharmacy at TTUHSC as a new tenure-track assistant professor in September 2010 with the long-term goal of establishing a research program which is nationally/internationally recognized in the immuno-pharmacology of nanoparticles. My immediate research focus was on identifying novel immune mechanisms of resistance to anticancer nanoparticles. The overall goal of my research is to understand the consequences of the interactions between nanoparticles and the host immune system in order to develop novel strategies to maximize the efficacy of nanoparticle drugs.

Research Interests

nanoparticles
oncology
immunology
pharmacology

Selected Publications:

  • La-Beck I, Jean G, Huynh C, Alzghari SK, Lowe D. Immune Checkpoint Inhibitors: New Insights and Current Place in Cancer Therapy.. Pharmacotherapy 2015;35(10):963-76.
  • Golan T, Grenader T, Ohana P, Amitay Y, Shmeeda H, La-Beck I, Tahover E, Berger R, Gabizon AA. Pegylated liposomal mitomycin C prodrug enhances tolerance of mitomycin C: a phase 1 study in advanced solid tumor patients.. Cancer medicine 2015;4(10):1472-83.
  • Rajan R, Karbowniczek M, Pugsley HR, Sabnani MK, Astrinidis A, La-Beck I. Quantifying autophagosomes and autolysosomes in cells using imaging flow cytometry.. Cytometry. Part A : the journal of the International Society for Analytical Cytology 2015;87(5):451-8.
  • Sabnani MK, Rajan R, Rowland B, Mavinkurve V, Wood L, Gabizon AA, La-Beck I. Liposome promotion of tumor growth is associated with angiogenesis and inhibition of antitumor immune responses.. Nanomedicine : nanotechnology, biology, and medicine 2015;11(2):259-62.
  • Caron WP, Lay JC, Fong AM, La-Beck I, Kumar P, Newman SE, Zhou H, Monaco JH, Clarke-Pearson DL, Brewster WR, Van Le L, Bae-Jump VL, Gehrig PA, Zamboni WC. Translational studies of phenotypic probes for the mononuclear phagocyte system and liposomal pharmacology.. The Journal of pharmacology and experimental therapeutics 2013;347(3):599-606.
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