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Profile for Quentin Smith, PhD, BA

Quentin Smith

Quentin Smith, PhD, BA

  • Dean
  • Senior Associate Dean
  • Senior Associate Dean for Sciences
  • Committee Member
Office Phone: 806-414-9277
Email: Quentin.Smith@ttuhsc.edu
Mail Address: 1300 S Coulter Dr
Amarillo TX 79106

Biography

Quentin Smith’s primary research interests are focused on assessing and ultimately improving drug delivery across the blood-brain barrier for the treatment of brain tumors, stroke, and neurodegenerative disease. He has established highly sensitive, regio-specific methods to map the distribution of low levels of bound and free drug in brain and brain metastases of breast cancer following systemic drug administration in animals. His lab is dissecting the roles of key BBB transporters in controlling brain and brain metastasis exposure of drugs. Also, he is working on developing and evaluating modified drugs that are specifically designed to circumvent the BBB. Both novel carrier vectors to deliver conventional drugs and rational design of drug modifications that retain chemotherapeutic activity while circumventing the transporters that limit brain access are being investigated. Research is funded by the Cancer Prevention Research Incentive of Texas (CPRIT), DoD, NIH, and numerous collaborations with industry.

Research Interests

Blood Brain Barrier, Drug Transport, Cancer Chemotherapy

Selected Publications:

  • Levin VA, Tonge PJ, Gallo JM, Birtwistle MR, Dar AC, Iavarone A, Paddison PJ, Heffron TP, Elmquist WF, Lachowicz JE, Johnson TW, White FM, Sul J, Smith QR, Shen W, Sarkaria JN, Samala R, Wen PY, Berry DA, Petter RC. CNS Anticancer Drug Discovery and Development Conference White Paper.. Neuro-oncology 2015;17 Suppl 6:vi1-26.
  • Spector R, Keep RF, Robert Snodgrass S, Smith QR, Johanson CE. A balanced view of choroid plexus structure and function: Focus on adult humans.. Experimental neurology 2015;267:78-86.
  • Morikawa A, Peereboom DM, Thorsheim HR, Samala R, Balyan R, Murphy CG, Lockman PR, Simmons A, Weil RJ, Tabar V, Steeg PS, Smith QR, Seidman AD. Capecitabine and lapatinib uptake in surgically resected brain metastases from metastatic breast cancer patients: a prospective study.. Neuro-oncology 2015;17(2):289-95.
  • Rajendar MK, Liu X, Adkins CE, Smith QR, Lockman PR. Paclitaxel-Hyaluronic Nano-Conjugates Prolong Overall Survival in a Preclinical Brain Metastases of Breast Cancer Model. Molecular Cancer Therapeutics 2013.
  • Kalvass JC, Smith QR, Kim BL. Why clinical modulation of efflux transport at the human blood-brain barrier is unlikely: the ITC evidence-based position.. CLin Pharmacol Ther 2013;94(1):80-94.
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