Faculty & Staff Details
|Name:||Quentin R. Smith|
|Position:||Dean, Professor of Pharmaceutical Sciences|
|Bio||Dr. Smith holds a Bachelor's degree in Chemistry from Oberlin College and a Ph.D. in Pharmacology from the University of Utah. Prior to coming to Texas, he worked for 17 years at the National Institutes of Health attaining the rank of Section Chief in the National Institute on Aging. He transferred to Texas Tech in 1997 to help build the new School of Pharmacy. His primary research interests are in drug development and delivery to the central nervous system for the treatment of brain tumors, stroke, and neurodegenerative disease. He is a Fellow of the American Association of Pharmaceutical Scientists and a Grover E. Murray Professor. His research is funded by the National Institutes of Health and the Department of Defense Breast Cancer Research Program.|
B.S., Oberlin College, Oberlin OH, 1976. Major: Chemistry;
Ph.D. University of Utah School of Medicine,Salt Lake City, Utah, 1980. Speciality: Pharmacology
Postdoctoral Fellowship Gerontology Research Center, 1980-84
Drug design and delivery to the central nervous system
New therapeutics for:
Brain tumors or infections
Role of blood-brain barrier in determining drug exposure to central nervous system
Active and facilitated transport
Transporters (Pgp, MRP, BCRP, OAT, OCT, OATP, GLUT, LAT, ENT, CNT)
Changes in brain vascular endothelium structure and function in health and disease
Roles of free and bound drug in brain pharmacodynamic effect
1. Parepally JMR., Mandula H, and Smith QR: Brain uptake of nonsteroidal anti-inflammatory drugs – ibuprofen, flurbiprofen and indomethacin. Pharm Res 23: 873-881, 2006.
2. Mandula H, Parepally JMR, Feng R, and Smith QR: Role of site-specific binding to plasma albumin in drug availability to brain. J Pharmacol Exp Ther 317: 667-675, 2006.
3. Doolittle ND, Peereboom DM, Christoforidis GA, Hall WA, Palmieri D, Brock PR, Campbell K, Dickey DT, Muldoon LL, O’Neill BP, Peterson DR, Pollock B, Soussain C, Smith QR, Tyson RM, and Neuwelt EA: Delivery of Chemotherapy and Antibodies Across the Blood-Brain Barrier and the Role of Chemoprotection in Primary and Metastatic Brain Tumors. J Neurooncol 81: 81-92, 2007.
4. Niture SK, Velu CS, Smith QR, Bhat GJ, and Srivenugopal KS: Increased expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines. Carcinogenesis 28: 378 - 389, 2007.
5. Muldoon LH, Soussain C, Janke K, Johanson C, Seigal T, Smith QR, Hall WA, Hynynen K, Senter P, Peereboom DM, and Neuwelt E: Chemotherapy delivery issues in central nervous system malignancy: A reality check. J Clin Oncology 25: 2295 - 2305, 2007.
6. Palmieri D, Smith QR, Lockman PR, Bronder J, Gril B, Chambers AF, Weil RJ, and Steeg, PS: Brain metastases of breast cancer. Breast Dis 26:139-147, 2007.
7. Kumar G, Smith QR, Hokari M, Parepally J, and Duncan MW: Brain uptake, pharmacokinetics, and tissue distribution in the rat of neurotoxic N-butylbenzenesulfonamide. Toxicol Sci 97: 253-264, 2007.
8. Neuwelt E, Abbott NJ, Abrey L, Banks WA, Blakley B, Davis T, Engelhardt B, Grammas P, Nedergaard M, Nutt J, Pardridge W, Rosenberg GA, Smith Q, Drewes LR: Strategies to advance translational research into brain barriers. Lancet Neurol 7(1):84-96. 2008.
9. Lockman PR, Gaasch JA, Borges K, Ehlo A, and Smith QR: Using WebCt to implement a basic science competency education course. Am J Pharm Educ 72: 39, 2008.
10. Yoo MJ, Smith QR, and Hage DS: Studies on imipramine binding to human serum albumin by high performance affinity chromatography. J. Chromatography B, 877: 1149-1154, 2009.
11. Zhang SQ, Thorsheim HR, Penugonda S, Pillai VC, Smith QR, Mehvar R: Liquid chromatography-tandem mass spectrometry for the determination of methylprednisolone in rat plasma and liver after intravenous administration of its liver-targeted dextran prodrug. J Chromatogr B Analyt Technol Biomed Life Sci. 877(10):927-32, 2009.
12. Fike DS, McCall KL, Raehl CL, Smith QR, and Lockman PR: Achieving equivalent academic performance between campuses using a distributed education model. Am J Pharm Educ 73: 88, 2009.
13. Palmieri D, Lockman PR, Thomas FC, Hua E, Herring J, Hargrave E, Johnson M, Flores N, Qian Y, Vega-Valle E, Taskar KS, Rudraraju V, Mittapalli RK, Gaasch JA, Bohn KA, Thorsheim HR, Liewehr DJ, Davis S, Reilly J, Walker R, Bronder JL, Feigenbaum L, Steinberg SM, Camphausen K, Meltzer PS, Richon VM, Smith QR, and Steeg PS: Vorinostat inhibits brain metastatic colonization in a model of triple-negative breast cancer and induces DNA double-strand breaks. Clin Cancer Res 15: 48-57, 2009.
14. Thomas FC, Taskar K, Rudraraju V, Goda S, Thorsheim HR, Gaasch JA, Palmieri D, Steeg PS, Lockman PR, and Smith QR: Uptake of ANG1005 – a novel paclitaxel-peptide derivative, through the blood-brain barrier into brain and experimental brain metastases of breast cancer. Pharm Res 26: 2486 – 2492, 2009.
15. Fike DS, McCall KL, Estes FG, Ndefo UA, Rahel CL, Smith QR and Lockman PR: Improving educational outcomes of Hispanic students in a professional degree program. Equity & Excellence in Education. In press, 2010.
16. Matharu J, Oki J, Worthen DA, Smith QR, and Crooks PA: Regiospecific and conformationally restrained analogs of melphalan and DL-2-NAM-7 and their affinities for the large neutral amino acid transporter (System LAT1) of the blood-brain barrier. Bioorg Med Chem Lett 20: 3688-3691, 2010.
17. Tong Z, Schiel JE, Papastavros E, Ohnmacht CM, Smith QR, Hage DS: Kinetic studies of drug-protein interactions by using peak profiling and high-performance affinity chromatography: Examination of multi-site interactions of drugs with human serum albumin columns. J Chromatogr A. In Press, (Oct 23 Epub ahead of print), 2010.
18. Lockman PR, Mittapalli RK, Taskar KS, Rudraraju V, Gril B, Bohn KA, Adkins CE, Roberts A, Thorsheim HR, Gaasch JA, Huang S, Palmieri D, Steeg PS, Smith QR: Heterogeneous blood-tumor barrier permeability determines drug efficacy in experimental brain metastases of breast cancer. Clin Cancer Res 16(23):5664-78, 2010.
19. Smith QR and Lockman PR: Prodrug approaches for central nervous system drug delivery. Meth Principles Med.Chem 47:253-270, 2011.