The Wendy and Stanley Marsh 3 Endowed Lectureship
in Pharmacology & Neurochemistry of Substance Abuse/Addiction
The Wendy and Stanley Marsh 3 Endowed Lectureship in Pharmacology and Neurochemistry of Substance Abuse/Addiction is an annual event with speakers of the highest national reputation that address audiences in Amarillo. Attendance is open to the public, and interested lecturers, typically in the area of research, are invited to apply. Additionally, grand rounds will address the clinical applications of the speaker's ongoing research.
This endowment was funded by the Marshes in an effort to give the Texas Tech School of Pharmacy national recognition in the pharmacologic area of substance abuse and the neurochemistry that precipitates this addictive behavior.
If you would like to receive an invitation to lecture, please email Logan Larue OR send your name and address to:
Texas Tech University Health Sciences Center
School of Pharmacy
Office of the Regional Dean
Amarillo, Texas 79106
The 2009 Wendy and Stanley Marsh Endowed Lectureship
Awarded to Dr. Fulton Crews
Fulton T. Crews is a neuropsychopharmacologist who, for many years, has investigated how drugs change the brain and behavior. The overarching hypothesis of his research is that structural and functional changes in brain associated with binge drinking contribute to the cognitive changes that lead to addiction. His early studies investigated ethanol and neurotransmission with more recent studies following changes in gene expression that contribute to a progressive degeneration with increasing impulsive-compulsive drug taking. He discovered that heavy alcohol use damages cortical brain regions involved in impulse control and planning: capabilities that help individuals weigh recalled negative and positive consequences before taking actions, such as drinking. These findings indicated alcohol abuse changes brain structure. He found genetic and age-related risk factors influence vulnerability to alcohol-induced brain damage. He was the first to discover that adult brain stem-progenetor cells are insulted by alcohol. Recently he discovered persistent brain neuroinflammatory gene induction secondary to systemic cytokines and reduced neurogenesis as factors in alcohol-related brain damage. Further, he discovered that recovery of brain function during abstinence includes a regenerative process with many new neurons and other brain cells being formed during abstinence from alcohol. These studies support the hypothesis that addiction and recovery from addiction are reflected in drug induced neurodegeneration and abstinence induced regeneration of the brain respectively. Dr. Crews is also among the few neuroscientists investigating the adolescent brain as a unique neurodevelopmental period that has considerable risk for future alcoholism.
The 2008 Wendy and Stanley Marsh 3 Endowed Lectureship
Awarded to Dr. John Crabbe
John Crabbe has been at the VA Medical Center and in Behavioral Neuroscience at the Oregon Health & Science University in Portland since 1979. He is director of the NIH Portland Alcohol Research Center. He entered graduate school at the University of Colorado to obtain a Ph.D. in social psychology. Fortuitously, Crabbe was sidetracked into studying behavioral genetics and neuroscience at the fledgling Institute for Behavioral Genetics in Boulder. He has been surrounded by mice ever since. His interest is in understanding individual differences in behavioral susceptibility to drugs of abuse, particularly alcohol, and their neurobiological and genetic bases. One of his research projects involves developing laboratory measures of alcohol withdrawal and seeking specific genes that lead to risk. Most recently, he has begun to selectively breed mouse lines that voluntarily drink alcohol until they become intoxicated, i.e., develop a mouse model of university students.
The 2007 Wendy and Stanley Marsh 3 Endowed Lectureship
Awarded to Dr. Michael Kuhar
Dr. Kuhar received his Ph.D. from The Johns Hopkins University in 1970, after which he joined the Yale University School of Medicine postdoctoral program. In 1972, he returned to The Johns Hopkins University as an assistant professor and became professor in 1981. From 1988-1995, he served as Chief of the Neuroscience Branch of the Addiction Research Center at the National Institution on Drug Abuse. Dr. Kuhar joined his current position at Emory University in 1996. His general area of interest has been brain structure and function, neuropsychiatric disease, and drugs that affect the brain. He has focused on drug addiction as a major research topic for the last many years. He has many research contributions and is one of the most highly cited scientist world wide. He has trained a large cadre of students, fellows and visitors, received a number of prestigious awards for his work and remains involved in all aspects of the research and education effort.
The 2006 Wendy and Stanley Marsh 3 Endowed Lectureship
Awarded to Dr. Adron Harris
Adron Harris received his Ph.D. in Pharmacology from the University of North Carolina in 1973 and conducted his postdoctoral work at the University of California at San Francisco. Dr. Harris has received numerous awards for his research on alcoholism, including the Pharmaceutical Manufacturer's Association Foundation Faculty Development Award, Veterans Administration Alcoholism Research Award and a Distinguished Research Award in 1999. Dr. Harris served as President of the Research Society on Alcoholism from 1993-1995 and is currently President of the International Society for Biomedical Research on Alcoholism. He served as the Scientific Director of the Denver Veteran's Administration Alcohol Research Center from 1992-1998 and as the Director of the Colorado Center for Alcoholism at the University of Colorado Medical School from 1992-1998. In 1998, he moved to the University of Texas, where he holds the M. June and J. Virgil Waggoner Chair in Molecular Biology and is the Director of the newly-established Waggoner Center for Alcohol and Addiction Research. Dr. Harris' laboratory is investigating structure and function of ion channels with emphasis on molecular mechanisms responsible for alcohol and drug actions. They are defining the acute actions of alcohol and other drugs on cell signaling as well as the long-term actions responsible for tolerance and dependence. They are also studying the neurochemical basis for genetic differences in drug response. These experiments use genetically modified mice that vary in susceptibility to drug intoxication and dependence.
The 2005 Wendy and Stanley Marsh 3 Endowed Lectureship
awarded to Dr. Thomas R. Kosten
Thomas R. Kosten, M.D. is a Professor of Psychiatry and Medicine at Yale University Medical School and Deputy Chief of Psychiatry at VA Connecticut. He has been supported by a Research Scientist Award from the National Institutes of Health since 1987 and directs the Yale Medications Development Center for substance abuse. He has served on national and international review groups for medications development in substance abuse. He has served as a Congressional Fellow in the House of Representatives and as a visiting professor in Germany, Spain, Greece, China and Canada. He is the founding Vice Chair for Added Qualifications in Addiction Psychiatry of the American Board of Psychiatry and Neurology. He is a Distinguished Fellow in the American Psychiatric Association, Fellow of the American College of Neuropsychopharmacology, and Past President of the American Academy of Addiction Psychiatry. He has won several major awards for clinical research and has been on the editorial boards of the major journals in substance abuse as well as the American Journal of Psychiatry. Recent work includes serving on the National Academy of Sciences, Institute of Medicine Committee on ethical issues in developing vaccines for substance abuse. From his studies in substance dependence, post traumatic stress disorder, and neuroimaging, he has published over 400 papers, books and reviews. His research includes treatment of cocaine-induced cerebral perfusion defects, as detected with SPECT neuroimaging, and prediction of pharmacotherapy outcome, based on functional MRI brain activation during cocaine cue-induced craving. His medication contributions include developing a cocaine vaccine, immunotherapy for hallucinogens, buprenorphine for opioid dependence, disulfiram for cocaine dependence, vasodilators for cocaine-induced cerebral perfusion defects, and using combined medications with contingency management for opioid and cocaine dependence.
The 2004 Wendy and Stanley Marsh 3 Endowed Lectureship - Cancelled
The 2003 Wendy and Stanley Marsh 3 Endowed Lectureship
awarded to Dr. Marc G. Caron
Dr. Marc G. Caron is an Investigator from the Howard Hughes Medical Institute and a James B. Duke Professor of Cell Biology at Duke University Medical Center. He is a native of Quebec, Canada. He received his B.Sc. in Biochemistry from Laval University in Quebec and his Ph.D. in Biochemistry from the University of Miami, Florida. After two years of postdoctoral work at Duke University, Dr. Caron returned to Laval University as an Assistant Professor. In 1977, however, he returned to Duke University Medical Center where he rose through the ranks to his current appointment as James B. Duke Professor of Cell Biology and Research Professor of Medicine. Dr. Caron was appointed Investigator of Howard Hughes Medical Institute in 1992. His research interests have been on the mechanism of signal transduction and regulation of G protein coupled receptors. More recently, Dr. Caron's interests have included how neurotransmitter transporters and receptors regulate responsiveness and central nervous system function. Dr. Caron has recently served as Associate Editor of Biochemistry and Editor-in-Chief of Endocrine Reviews. Dr. Caron has also served on NIH Study Sections and most recently on the Board of Scientific Counselors of NIDA.
The 2002 Wendy and Stanley Marsh 3 Endowed Lectureship
awarded to Dr.Robert C. Malenka
Dr. Robert C. Malenka is the Pritzker Professor of Psychiatry and Behavioral Sciences and Director of the Pritzker Laboratory at the Stanford University School of Medicine. He is a world leader in elucidating the mechanisms underlying the action of neurotransmitters in the mammalian brain & the molecular mechanisms by which neural circuits are reorganized by experience.
Dr. Malenka received his undergraduate education at Harvard (1978) in biology. He received an M.D. & a Ph.D. in neuroscience at Stanford School of Medicine (1983). Dr. Malenka completed 4 years of residency training in psychiatry at Stanford and 4 years of postdoctoral work with Roger Nicoll at the U.C.S.F. He was appointed Assistant Professor of Psychiatry and Physiology at U.C.S.F. & then promoted to Professor of Psychiatry & Physiology. He was also the Director of the Center for the Neurobiology of Addiction & Associate Director of the Center for Neurobiology & Psychiatry. He returned to Stanford School of Medicine in 1999 to become the Director of the Pritzker Laboratory in the Dept. of Psychiatry and Behavioral Science.
Dr. Malenka has been the recipient of research awards including: the Society for Neuroscience Young Investigator Award (1993); the Daniel H. Efron Award from the American College of Neuropsychopharmacolgoy (1998); the Dargut and Milena Kemali Foundation International Prize in Neuroscience (2000); a MERIT Award from N.I.M.H. (2001-2011); a Scholars Award in Neuroscience (1990) and Investigator Award in Neuroscience (1997) from the McKnight Endowment Fund for Neuroscience: an Independent Scientist Award from N.I.M.H. (1996); a Young Investigator Award from the National Alliance for Research in Schizophrenia & Depression (1990, 1992); an Alfred P. Sloan Research Fellowship (1990); & a Distinguished Alumni Award from Stanford Medical School (1998). His public service includes being on the National Advisory Council on Drug Abuse, the Program Committee for the Society for Neuroscience, & the editorial boards of several prominent journals.
Dr. Malenka’s has published over 125 research papers and has recently co-authored a textbook Molecular Neuropharmacology: A Foundation for Clinical Neuroscience (McGraw Hill, 2001). He has lectured at universities and scientific meetings throughout the United States, Europe and Japan.
The 2001 Wendy and Stanley Marsh 3 Endowed Lectureship
awarded to Dr. Mary Jeanne Kreek
Mary Jeanne Kreek is a graduate of Wellesley College where she received Honors in chemistry and biology and also of the Columbia University College of Physicians and Surgeons where she received the M.D. degree. Dr. Kreek is now Professor and Head of Laboratory at the Laboratory of the Biology of Addictive Diseases at the Rockefeller University and Senior Physician of the Rockefeller University Hospital in New York City. Her Laboratory includes molecular biologists, chemists, cell biologists, neuroscientists and psychologists, and physicians working in a coordinated manner to study the molecular, cellular and behavioral neurobiology of addictive diseases and related clinical neurobiology and molecular genetics of the addictions.
The 2000 Wendy and Stanley Marsh 3 Endowed Lectureship
awarded to Dr. Marc A. Schuckit
Marc A. Schuckit received his Bachelor of Science degree from the University of Wisconsin and his M.D. from Washington University Medical School. Dr. Schuckit is board certified in Psychiatry by the American Board of Psychiatry and Neurology, Inc. He currently holds positions as Professor in the Department of Psychiatry at the University of California-School Medicine in San Diego, CA, Editor of the Journal of Studies on Alcohol, Director of the Alcohol Research Center and Director of the Alcohol and Drug Treatment Program at the Veterans Affairs Medical Center in San Diego, CA, and Clinical Director of the Scripps McDonald Center for Alcoholism and Drug Addiction Treatment in La Jolla, CA.
The 1999 Wendy and Stanley Marsh 3 Endowed Lectureship
awarded to Dr. George F. Koob
George F. Koob received his Bachelor of Science degree from Pennsylvania State University and his Ph.D in Behavioral Physiology from the Johns Hopkins University. An authority on addiction and stress, Dr. Koob has published over 450 scientific papers. He has received funding for his research from the National Institutes of Health, including the National Institute on Drug Addiction and the National Institute on Alcohol Abuse and Alcoholism, where he is a Merit Awardee. Dr. Koob's current research is focused on the exploration of the neurobiological basis for the neuroadaption associated with drug dependence and stress. His work not only provides the basic research knowledge about the function of specific neurotransmitters in specific neuroanatomical sites but also provides significant information about the central nervous system action of drugs and the neuropharmacological basis of psychopathology.
The 1998 Wendy and Stanley Marsh 3 Endowed Lectureship
awarded to Dr. Charles P. O'Brien
Charles P. O'Brien received the M.D., Ph.D. from Tulane University. His residency training was in internal medicine, neurology and psychiatry at Harvard, University of London, Tulane, and University of Pennsylvania. He is board certified in neurology, psychiatry and addiction psychiatry. His research interests include the psychopharmacology of addiction and the development of new behavioral and pharmacological treatments for addiction including alcoholism. His research group has been responsible for numerous discoveries that have improved the results of treatment for addictive disorders. He was elected to the Institute of Medicine of the National Academy of Sciences in 1991.
The 1997 Wendy and Stanley Marsh 3 Endowed Lectureship
awarded to Dr. Eric J. Nestler
Dr. Eric J. Nestler, M.D., Ph.D. received his B.A. from Yale in 1976 and his Ph.D. from Yale in 1982. Dr. Nestler completed his training in Psychiatry at McLean Hospital and Yale in 1987. His research seeks to identify molecular changes that drugs of abuse produce in the brain to cause addication. Dr. Nestler's professional memberships include the American Association for the Advancement of Science, the American Board of Psychiatry and Neurology, the American College of Neuropsychopharmacology, and the American Psychiatric Association.