TTUHSC Clinical Research Institute
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Right now we need your help with these projects:

  1. Pseudomonas chemotaxis in blood- the effect of thermal injury:  (IRB: 13-140) Pseudomonas aeruginosa is a gram negative pathogen that infects acute wounds such as third degree skin injury. From these infection sites P. aeruginosa translocates into the bloodstream causing septicemia resulting in a high mortality rate. While different in vitro and in vivo studies have analyzed the effect of the environment at different infection sites on P. aeruginosa virulence, little is known regarding the effect of blood during systemic infection. We hypothesize that human blood obtained from thermally injured individuals will significantly alter the expression of P. aeruginosa genes. We are recruiting 20 subjects, age 18-89 years who are admitted to the Timothy J Harnar Burn Center with thermal injury totaling 20% TBSA or greater.
  2. The effect of trauma on Pseudomonas aeruginosa gene expression in blood:  (IRB: 15-057) Pseudomonas aeruginosa is a gram negative pathogen that infects acute wounds and translocates into the bloodstream causing septicemia resulting in a high mortality rate.  In previous studies using RNA sequencing analysis, we have found that P. aeruginosa expressed altered genes when grown in whole blood from injured patients.  However, little is known regarding the effect of blood during systemic infection.  Identifying significantly altered P. aeruginosa genes in patients following trauma could influence treatment of trauma patients who develop systemic infection.  We are recruiting 32 patients with severe trauma and 32 healthy volunteers.  We will obtain blood samples of about 35 ml from a single blood draw.  Healthy volunteers are compensated $25.  Currently there is a need for 10 healthy male volunteers and 4 healthy female volunteers.
  3. RNAsequence Analysis of Microbial Gene Expression in Necrotizing Soft Tissue Infections (IRB: 14-002)
    To learn about the causative agents of the skin and soft tissue infections and risk factors involved in acquiring these infections.  While the patient is in the operating room, small specimens will be taken from the infected tissue.
    Admitted to University Medical Center with the diagnosis of skin and soft tissue
    18 years of age or older
    Be willing to provide tissue samples for RNA sequencing analysis
  4. Does abnormal neuromuscular junction function play a role in the pathogenesis of motor fatigue in women with multiple sclerosis? (IRB: L15-098)
    $50.00 stipend paid in 2 - $25.00 increments 
    Multiple Sclerosis (MS) affects more than 2.3 million people worldwide, especially women of childbearing age. Fatigue is a common complaint in MS. In fact, many MS patients list fatigue as their worst symptom and as a barrier to employment. The purpose of this study is to find out if motor fatigue in MS patients is related to problems between the muscle and nerve. The study will compare 20 women with MS to 10 women without MS. We hope that this study will lead to better treatment to improve the quality of life of women with MS.    

    Inclusion Criteria for MS Group (20 women):
    1.    Patients with relapsing remitting multiple sclerosis.
    2.    Age 18 to 65 years
    3.    Diagnosed with motor fatigue in multiple sclerosis > 6 weeks. Motor fatigue equates to muscle fatigue due to physical exertion and is alleviated with rest and associated with fatigability.
    4.    Has a fatigue severity scale score (FSS) of ≥5 (moderate to severe fatigue).
    5.    Ambulatory with Expanded Disability Status Scale score (EDSS) 1.5 -6.5.
     
    Inclusion Criteria for Control Group (10 women):
    1.    Female with no history of multiple sclerosis and no complaint of fatigue
    2.    Age 18 to 65 years  
  5.  Using Behavioral Economics to Achieve Improved Healthy Behavior Outcomes in Breast Cancer Survivors (IRB: 15-178) The purpose of this study is to find out if daily text messages can encourage healthy behavior in breast cancer survivors. Healthy habits can help reduce or prevent obesity. Reducing obesity may lead to a better quality of life for this group of patients. During this study, participants will receive daily text messages. Half will receive messages about diet and exercise. The other half will receive neutral messages about the state of Texas. We will compare the two groups using a behavioral survey. Blood and urine samples will also be taken for physiological measures.  
    $50.00 stipend paid in 2- $25.00 increments

    Inclusion Criteria
    Female
    Body mass index (BMI): 25-45 kg/m2
    Age: 20-75 years old
    No current pregnancy or lactation
    Was diagnosed with Stage 0-IIIB disease within the past 5 years and completed all local and systemic therapy (including Herceptin) at least 3 months prior to entry. Women can be on or off anti-hormone therapy.
    Currently sedentary (exercise < 2´/week for 30 minutes at moderate intensity in the past 6 months)
    Ambulatory without assistive devices.

To get more information, or to volunteer, e-mail us at clinicalresearch@ttuhsc.edu or give us a call at 806-543-8994.

(Please leave a message if we do not answer- we might be with another volunteer!)

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