Ashly Hindle | Texas Tech University Health Sciences Center
Ashly Hindle

Ashly Hindle

Postdoctoral Research Associate

 

I graduated in 2019 from the TTUHSC Graduate School of Biomedical Sciences in Lubbock, Texas where I studied the contribution of MGMT, a DNA repair protein, to chemotherapeutic drug resistance in neuroblastoma. We found that depletion of MGMT using a small molecule inhibitor improved the response to temozolomide and irinotecan in models of progressive disease neuroblastoma. From 2019-2021 I worked as a postdoc at TTUHSC studying the role of RLIP76, a multifunctional stress-tolerance protein, in breast cancer and lung cancer. We evaluated the anticancer effects of RLIP76-targeted treatments and studied the regulation of oncogenes and tumor suppressor genes following depletion of RLIP76. In September 2021 I started as a postdoc in Dr. Reddy’s lab where I am studying the role of RLIP76 in Alzheimer’s disease. Specifically we are studying whether RLIP76 affects key mitochondrial and synaptic biomarkers of Alzheimer’s disease and whether RLIP76 expression can offer protection against neurodegeneration.