Pharmaceutical Sciences

inarivala
  • Graduate Student / Research Assistant
Lab Phone: 806-414-9259
E-Mail: nihar.kinarivala@ttuhsc.edu
Mail Address: 1300 S Coulter
Amarillo, TX 79106-1712

Biography

Nihar Kinarivala completed his Bachelor of Pharmacy degree from the Nirma University of Ahmedabad, India. He enrolled as a PhD student in the Graduate Program of Pharmaceutical Sciences at TTUHSC in August 2013. At present, he is working in the laboratory of Dr. Paul Trippier with the Department of Pharmaceutical Sciences. Currently, Nihar is working on the synthesis of novel neuroprotective molecules which could be useful in Batten disease.

Education:

  • BPharm: Pharmacy, Nirma University, India, 2013

Research Interests:

Medicinal chemistry; Drug discovery; Organic chemistry.

Publications:

  • Kinarivala N, Patel R, Boustany RM, Al-Ahmad A, Trippier PC. Discovery of Aromatic Carbamates that Confer Neuroprotective Activity by Enhancing Autophagy and Inducing the Anti-Apoptotic Protein B-Cell Lymphoma 2 (Bcl-2). J Med Chem. 2017 Dec 14;60(23):9739-9756.
  • Wang H, Huwaimel B, Verma K, Miller J, Germain TM, Kinarivala N, Pappas D, Brookes PS, Trippier PC. Synthesis and Antineoplastic Evaluation of Mitochondrial Complex II (Succinate Dehydrogenase) Inhibitors Derived from Atpenin A5. ChemMedChem. 2017 Jul 6;12(13):1033-1044.
  • Kinarivala N, Shah K, Abbruscato TJ, Trippier PC. Passage Variation of PC12 Cells Results in Inconsistent Susceptibility to Externally Induced Apoptosis. ACS Chem Neurosci. 2017 Jan 18;8(1):82-88. Epub 2016 Oct 20.
  • Kinarivala, N, Suh, JH, Botros, M, Webb, P, Trippier, PC. Pharmacophore elucidation of phosphoiodyn A - Potent and selective peroxisome proliferator-activated receptor β/δ agonists with neuroprotective activity. Bioorg Med Chem Lett. 2016 Apr 15;26(8):1889-93. Epub 2016 Mar 9.
  • Kinarivala N, Trippier PC. "Progress in the Development of Small Molecule Therapeutics for the Treatment of Neuronal Ceroid Lipofuscinoses (NCLs)". J Med Chem. 2016 May 26;59(10):4415-27. Epub 2015 Nov 24.
  • Nihar Kinarivala, Paul C. Trippier. "Exploration of relative chemoselectivity in the hydrodechlorination of 2-chloropyridines." Tetrahedron Letters. 2014 Sep 24. 55(39): p. 5386-5389.

Presentations:

  • Nihar Kinarivala, Ronak Patel, Abraham Al-Ahmad, Paul C. Trippier. "Discovery and development of functionalized aromatic carbamates for the treatment of neurodegeneration". American Chemical Society, Southwest Regional Meeting, Lubbock, TX; Oct.-Nov.2017.
  • Nihar Kinarivala, Fadi Saadeh, Joelle Makoukji, Rose-Mary Boustany and Paul C. Trippier. "Design, Synthesis and Employment of Novel Chemical Probes for Neuroprotective Target Identification". Gordon Research Conference, Andover, NH; June 2017.
  • Nihar Kinarivala, Fadi Saadeh, Joelle Makoukji, Rose-Mary Boustany and Paul C. Trippier. "Design, Synthesis and Employment of Flupirtine-Derivative Chemical Probes for Neuroprotective Target Identification". American Chemical Society, San Diego, CA; April 2017.
  • Podium Presentation: Nihar Kinarivala, Paul C. Trippier. “Investigation of Flupirtine Structure-Activity Relationship for the treatment of Batten Disease.” Fifteenth Annual Research Days, TTUHSC School of Pharmacy, Amarillo, TX; June 2016.
  • Nihar Kinarivala, Fadi Saadeh, Joelle Makoukji, Rose-Mary Boustany, and Paul C. Trippier. "Investigation of Flupirtine Structure Activity Relationship for the Treatment of Batten Disease." 1st Annual Meeting, Center of Excellence for Translational Neuroscience and Therapeutics (CTNT), TTUHSC, Lubbock, TX; April 2016.
  • Nihar Kinarivala, Fadi Saadeh, Joelle Makoukji, Rose-Mary Boustany, and Paul C. Trippier. "Investigation of Flupirtine Structure Activity Relationship for the Treatment of Batten Disease." Student Research Week, TTUHSC Graduate School of Biomedical Sciences Lubbock, TX; March 2016.
  • Nihar Kinarivala, Joelle Makoukji, Fadi Saadeh, Rose-Mary Boustany and Paul C. Trippier. “Design, synthesis, and structure-activity relationships of flupirtine derivatives for the treatment of neuronal ceroid lipofuscinosis”. 10th Annual Drug Discovery for Neurodegeneration Conference, Alzheimer’s Drug Discovery Foundation, Miami, FL; March 2016.
  • Nihar Kinarivala, Joelle Makoukji, Fadi Saadeh, Rose-Mary Boustany, Paul Trippier. "Design, Synthesis, and Structure-Activity Relationships of Flupirtine Derivatives for the Treatment of Neuronal Ceroid Lipofuscinosis". Fourteenth Annual Research Days, TTUHSC School of Pharmacy, Amarillo, TX; June 2015.
  • Nihar Kinarivala and Paul C. Trippier. "Chemoselective Hydrodechlorination of 2-Chloropyridines Derivatives". Fourteenth Annual Research Days, TTUHSC School of Pharmacy, Amarillo, TX; June 2015.
  • Nihar Kinarivala, Joelle Makoukji, Fadi Saadeh, Rose-Mary Boustany, and Paul C. Trippier. "Design, Synthesis, and Structure-Activity Relationships of Flupirtine Derivatives for the Treatment of Neuronal Ceroid Lipofuscinosis". American Chemical Society, Denver, CO; March 2015.
  • Nihar Kinarivala, Fadi Saadeh, Joelle Makoukji, Rose-Mary Boustany, and Paul C. Trippier. "Investigation of Flupirtine Structure-Activity Relationship for the treatment of Batten Disease". Student Research Week, TTUHSC Graduate School of Biomedical Sciences, Lubbock, TX; March 2015.
  • Nihar Kinarivala, Fadi Saadeh, Joelle Makoukji, Rose-Mary Boustany, and Paul C. Trippier. "Investigation of Flupirtine Structure-Activity Relationships for the Treatment of Batten Disease." Thirteenth Annual Research Days, TTUHSC School of Pharmacy, Amarillo, TX; June 2014.

Seminars:

  • 11/10/2017 "Design, Synthesis and Evaluation of Aromatic Carbamates as Neuroprotective Agents" [DOCTORAL DISSERTATION DEFENSE] (presented within Seminar course sequence)
  • 08/30/2017 "Design, Synthesis and Employment of Flupirtine-Derivative Chemical Probes for Neuroprotective Target Identification"
  • 09/21/2016  "Optimization and Employment of Flupirtine-Derived Chemical Probes for Neuroprotective Target Identification"
  • 09/16/2015 "Synthesis and Structure Activity Relationship of Xanthohumol and it Analogues for the Treatment of Batten Disease" [Oral Qualifying Exam, public presentation]
  • 10/29/2014 "Repurposing Flupirtine for the Treatment of Batten Disease"

Awards/Scholarships:

  • Outstanding Young Investigator Scholarship, Alzheimer’s Drug Discovery Foundation (ADDF), March 2016
  • Dean’s Scholars Award, Graduate School of Biomedical Sciences, (every year until graduation), February 2016.

Memberships:

  • American Association for the Advancement of Science / Science Program for Excellence in Science. [nominated by Dr. Michael P. Blanton, Senior Associate Dean for the Graduate School of Biomedical Sciences; March 2015]
  • American Chemical Society, 2014-present
  • Graduate Student Association at Amarillo, 2013-present.
  • American Association of Pharmaceutical Scientists, 2013-present
  • Graduate Student Association at Amarillo – Historian, 2014-2015.
  • Graduate Student Association at Amarillo – 2013-present.
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